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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA)
Ikhsan Samir
Tanjungpura University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

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Antidiabetic Activity of Ethanol-Water Fraction of Longjack Root (Eurycoma longifolia Jack.) in Streptozotocin-Nicotinamide Induced Rats Wiwik Hartika; Michelle Terrence; Ikhsan Samir; Ruqiah Ganda Putri Panjaitan
Jurnal Penelitian Pendidikan IPA Vol 10 No 2 (2024): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i2.4759

Abstract

This study aims to determine the decrease in glucose levels, MDA levels, and histopathological appearance of the pancreatic organs of Wistar white rats after administration of the ethanol-water fraction of longjack root. This study used a completely randomized design with four treatment groups and six replications. The treatment consisted of normal control, negative control (Na-CMC 0.5% 5 ml/200 g body weight), positive control (glibenclamide 0.09 mg/200 g body weight), and treatment of the ethanol-water fraction of longjack root with a dose of 500 mg/kg body weight. The results showed that the ethanol-water fraction of longjack root at a dose of 500 mg/kg body weight had antidiabetic activity comparable to that of glibenclamide at a dose of 0.09/200 g body weight, namely blood glucose levels and MDA levels in white rats of 123.55 mg/dl and 2.83 nmol/ml. The results of histopathological analysis of the pancreas of white rats showed that administration of the ethanol-water fraction of longjack root could repair damage to the islets of Langerhans due to the administration of streptozotocin-nicotinamide.
Co-Authors Michelle Terrence Ruqiah Ganda Putri Panjaitan Wiwik Hartika