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All Journal Biology, Medicine, & Natural Product Chemistry
Virhan Novianry
Universitas Tanjungpura
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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The Antioxidant Activity and Acute Toxicity of Jamu Cekok: Kidney Histopathology Analysis of Female Wistar Puji Astuti; Virhan Novianry
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.69-75

Abstract

Jamu cekok is a traditional Indonesian herbal remedy for toddlers to improve appetite. While previous studies have shown benefits such as weight gain, its antioxidant activity and safety profile remain underexplored. This study evaluated the antioxidant potential and acute toxicity of jamu cekok, composed of Curcuma xanthorrhiza, Curcuma longa, Zingiber officinale, and Kaempferia galanga. Extracts were extracted with Aquadest and n-hexane, and antioxidant activity was assessed via the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Results showed weak antioxidant activity in both extracts (IC50: 481.59 ppm for decoction, 127.12 ppm for n-hexane), lower than some individual herbs. Moreover, an acute toxicity tests followed OECD 425 guidelines using female Wistar rats. No mortality occurred at doses up to 5,000 mg/kgBW, categorizing it as practically non-toxic. However, elevated creatinine levels and histopathological kidney changes, including degeneration and Bowman’s capsule dilation, were observed at higher doses. These findings suggest jamu cekok is safe at high doses but may induce temporary renal effects. Further research is needed to optimize formulations and evaluate long-term safety.
Analysis of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) Levels in Rats Given Jamu Cekok Decoction Risya Alfhadillah; Puji Astuti; Sari Rahmayanti; Virhan Novianry
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.189-198

Abstract

Jamu cekok is a traditional medicine used by Indonesians, especially children to increase appetite. However, the safety test of jamu cekok on liver function using Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) as parameters has never been evaluated. This study aimed to determine the effect of jamu cekok on liver function by assessing SGOT and SGPT levels in rats subjected to acute toxicity. The study employed an analytical experimental design with the OECD 425 method. The test rats used were 12, divided into a control group, a 2000 mg/kg BW treatment group and a 5000 mg/kg BW treatment group. The treatment of jamu cekok decoction was given once on the first day of the acute toxicity test and was observed for 14 days. SGOT and SGPT levels were measured and analyzed using one-way ANOVA to assess differences between groups. Through this study, observations of behavior and body weight over the 14 days showed no signs of toxicity or mortality. The LD50 value was determined to be greater than 5000 mg/kg BW, which is categorized as practically non-toxic. One-way ANOVA followed by Tukey’s HSD post hoc tests revealed no significant differences in SGOT levels between the control and treatment groups (p>0,05). Similarly, SGPT levels also showed no significant difference (p>0,05) between groups. These findings indicate that he administration of jamu cekok at a dose of 2000 mg/kg BW and 5000 mg/kg BW does not induce toxic effects on liver function, as reflected by SGOT and SGPT measurements.
Co-Authors Puji Astuti Risya Alfhadillah Sari Rahmayanti