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All Journal Sriwijaya Journal of Dentistry
Trisnawaty K
Dentistry Study Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Public Health

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Antifungal Activity of N-Hexane Extract of Duku Peel (Lansium domesticum Corr.) Against Candida albicans In Vitro Humaira Fitriana; Trisnawaty K; Shanty Chairani
Sriwijaya Journal of Dentistry Vol. 3 No. 2 (2022): Sriwijaya Journal of Dentistry
Publisher : Dentistry Study Program, Faculty of Medicine Universitas Sriwijaya 

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjd.v3i2.34

Abstract

Introduction: High colonization of Candida albicans in mouth can increase the risk of oral candidiasis. Duku peel (Lansium domesticum Corr.) has potential as antifungal material due to its terpenoid and phenolic content which can be extracted with n-hexane as solvent. Purpose: The purpose of this study is to determine the antifungal activity of n-hexane extract of duku peel against Candida albicans. Methods: This study used laboratorium experimental with post test only control group study design. Antifungal activity was determined using disc diffusion method on five sample groups: n-hexane extract of duku peel 15%, 20%, and 25%, nystatin as positive control, and aquadest as negative control. Antifungal activity was determined by measuring clear zone around the disc and measured with caliper in millimeter. The measurement of inhibition zone was analyzed with One Way ANOVA test. Results: There were no inhibition zone on n-hexane extract of duku peel with concentration of 15%, 20%, 25% and negative control while positive control had average inhibition zone diameter of 11,85 mm. Conclusion: N-hexane extract of duku peel with concentration of 15%, 20%, and 25% did not have antifungal activity against Candida albicans.
Antibacterial Potency of Prabumulih’s Pineapple Leaves Extract (Ananas comosus) Towards Enterococcus faecalis Diana Lestari; Rini Bikarindrasari; Trisnawaty K
Sriwijaya Journal of Dentistry Vol. 4 No. 2 (2023): Sriwijaya Journal of Dentistry
Publisher : Dentistry Study Program, Faculty of Medicine Universitas Sriwijaya 

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjd.v4i2.43

Abstract

Introduction: Unsuccessful elimination procedures of Gram-positive bacteria (Enterococcus faecalis) often lead to failure of endodontic treatment. It is necessary to use irrigation solutions to eliminate it from the root canal. The leaves of Pineapple (Ananas comosus) that are widely cultivated in Prabumulih have antibacterial properties due to active compounds such as bromelain enzymes, flavonoids, phenols, saponins, tannins, and alkaloids and have potential as an alternative material for root canal irrigation. Purpose: This study aimed to determine the antibacterial potency of Prabumulih pineapple leaf extract (Ananas comosus) against E. faecalis. Methods: This is an in vitro quasi-experimental laboratory study with a post-test-only control group study design. The test group consisted of Prabumulih pineapple leaf extract at concentrations of 1.56%, 3.125%, 6.25%, and 12,5% obtained using the maceration method. The positive control was NaOCl 2.5%, and distilled water was the negative control. The antibacterial activity of the extract using the disc diffusion method for the inhibition zone test, the dilution method for the minimum inhibitory concentration (MIC) test, and solid dilution for the minimum bactericidal concentration (MBC) test. Results: It showed that Prabumulih pineapple leaves extract has antibacterial potency against E. faecalis with the largest average inhibition zone at a concentration of 12.5% (2.324 mm), MIC at a concentration of 12,5%, and MBC also at a concentration of 12,5%. Conclusion: Prabumulih pineapple leaf extract has antibacterial potency against Enterococcus faecalis.
Co-Authors Diana Lestari Humaira Fitriana Rini Bikarindrasari Shanty Chairani