Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Bali Dermatology Venereology and Aesthetic Journal
We Sagara Dewi
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Hasanuddin, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
The effectiveness of galactomyces ferment filtrate, dexpanthenol, and Centella asiatica combination serum in the treatment of post-acne hyperpigmentation We Sagara Dewi; Ivan Kurniadi; Anis Irawan Anwar
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 2 (December 2020)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/dtmmz489

Abstract

Background: Acne vulgaris is a chronic inflammation of the pilosebaceous gland that may result in non-inflammatory and inflammatory lesions. A hypermelanotic reaction to skin inflammation causes post-acne hyperpigmentation (PAH). It can occur secondary to the inflammation process and, depending on the severity, may persist for a prolonged period. Objective To determine the effectiveness of galactomyces ferment filtrate (GFF), dexpanthenol, and Centella asiatica combination serum in the treatment of PAH Methods: This was a placebo-controlled randomized clinical trial. Sixty-eight subjects were divided into two groups: the experimental group received combination serum while the control group received a placebo for eight weeks. Three drops of serum were applied to the area with PAH twice daily in the morning and night. The melanin, erythema, roughness, and L*, a*, and b* scores were assessed objectively using mexameter, chromameter and skin analyzer every two weeks. Pearson’s correlation test and independent T-test were used to assess the trend of the parameters and compare the results of both groups. Results: The results of statistical calculations using the Pearson correlation test showed the treatment group showed a significant decreasing trend of the melanin and spots score. Both groups showed a significant decreasing trend in erythema, L* score and roughness. However, no significant difference was found between both groups in all parameters. Conclusion: The combination serum may decrease the melanin and spot scores suggesting that it affects the melanocyte activity. It has shown good efficacy in treating PAH.
Co-Authors Anis Irawan Anwar Ivan Kurniadi