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All Journal JURNAL KIMIA SAINS DAN APLIKASI
Rosaria Nainggolan
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Pondok Cina, Beji, Depok City, West Java 16424|Universitas Indonesia|Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering

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Metabolite Formation of Pesticide Isoprocarb in Coffee Beans During Short-Term Storage and Condition Rosaria Nainggolan; Asep Saefumillah; Endang Saefudin; Yanwar Pratama Putra
Jurnal Kimia Sains dan Aplikasi Vol 27, No 2 (2024): Volume 27 Issue 2 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.2.45-52

Abstract

Isoprocarb (IPC) is one of the most important carbamate pesticides for white flea control in coffee plants. The prevalence of isoprocarb pesticide residues in coffee, i.e., green coffee beans, is a cause for concern. Green coffee beans were intentionally contaminated with isoprocarb at concentrations >0.01 mg/kg, which was investigated in this research. Quantitative analysis of isoprocarb with the QuEChERS method and qualitative analysis for metabolite formation was characterized using UV-Vis, FTIR, 1H-NMR, GC-MS, and LC-QTOF-MS. Based on the data, the metabolite formed is o-cumenol through the hydrolysis reaction of o-aryl carbamate with the enzyme carboxylesterase. o-cumenol or 2- isopropylphenol as a phenol derivative. To verify the existence of metabolite analytes that are believed to be there in coffee tainted with isoprocarb, more reliable analytical techniques utilizing analytical standards must be developed. Isoprocarb concentrations decreased along the storage time, especially in unsterilized conditions. As a toxic compound, a quantitative structural activity relationship study (QSAR) was initially carried out through a software application for estimating toxicity (TEST) provided by the US Environmental Protection Agency (EPA). For additional information, based on the LC50 and LD50 data confirmed from the TEST application, it was concluded that isoprocarb is more toxic than o-cumenol.
Co-Authors Asep Saefumillah Endang Saefudin Yanwar Pratama Putra