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All Journal Muhammadiyah Medical Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Marsipature Hutanabe: Jurnal Pengabdian Kepada Masyarakat
Ningrum Wahyuni
Institut Kesehatan Helvetia
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Edukasi Pentingnya Menjaga Kesehatan Reproduksi Pada Anak Remaja Di SMA Angkasa 1 Lanud Medan Ningrum Wahyuni; Wan Tisya Muhaira; Hendri Meirialdi; Januarisman Andrian Saragih; Widia Maulida
Marsipature Hutanabe: Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 01 (2024): Marsipature Hutanabe: Jurnal Pengabdian Kepada Masyarakat
Publisher : CV. Devi Tara Innovations

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Abstract

Adolescence is one of the periods of human development. This is a time of change or transition from childhood to adulthood that includes biological, psychological, and social changes. Adolescence usually begins at the age of 10 – 13 years and ends at the age of 18 – 22 years. Meanwhile, according to WHO, adolescents are individuals who are experiencing a transition period that gradually reaches sexual maturity, experiences a change in the psyche from a child's soul to an adult, and experiences a change in economic circumstances from dependence to relative independence. There are two main aspects of change in adolescents, namely physical or biological changes and psychological changes. Many problems will arise as a result of neglecting reproductive health. Problems that arise due to lack of knowledge about reproductive health are Unwanted Pregnancy (KTD), abortion, early marriage and marriage, STIs or STDs and HIV/AIDS (Marmi, 2013). One of the efforts that can be made to reduce these numbers is by conducting health education about how to care for reproductive organs, education about adolescent development during puberty, health education about the impact of pornography, health education about unwanted pregnancies (KTD) and abortion, health education about HIV/AIDS and sexually transmitted infections, and health education about maturing the age of marriage with involving the role of the government, parents, and also peer groups. By carrying out these activities, it is hoped that it will be able to increase the knowledge of adolescents, so that it can increase adolescents' awareness of the importance of reproductive health problems. And reduce the incidence of adolescent reproductive health cases.
Edukasi Pentingnya Menjaga Kesehatan Mental Pada Anak Remaja Di SMA Negeri 3 Binjai Fitri Aidani Ulfa Hrp; Ekawaty Suryani Mastari; Ningrum Wahyuni; Emilia Putri Tarigan; Farhah Kamilatun Nuha
Marsipature Hutanabe: Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 01 (2024): Marsipature Hutanabe: Jurnal Pengabdian Kepada Masyarakat
Publisher : CV. Devi Tara Innovations

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Mental health problems have become unresolved health problems in society, both at the global and national levels. Especially during the COVID-19 pandemic, mental health problems will be more difficult to solve. The increasingly concerning condition of people's mental health will affect national productivity. This could hinder Indonesia from transitioning into a developed country by 2045. Mental health services are crucial and require the same attention as physical health. According to the Indonesia-National Adolescent Mental Health Survey 2022, 15.5 million (34.9 percent) adolescents experience mental problems and 2.45 million (5.5 percent) adolescents experience mental disorders. Of that number, only 2.6 percent accessed counseling services, both emotional and behavioral. The government has been thinking about mental health, but it has not been a priority. Access to mental health services is expensive and not inclusive. Meanwhile, attention to mental and physical health has not been equal in national health insurance. In Indonesia, we know many cases of adolescents aged 15-17 who experience excessive anxiety resulting in depression and suicide.
Uji Ekstrak N-Heksan Daun Kirinyuh (Chromolaena Odorata L.) Terhadap Model Hewan Luka Bakar Derajat IIA Wan Tisya Muhaira; Luthvia Luthvia; Ningrum Wahyuni; Indah Afriwanty Simatupang; Bayu Ariatama
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.514

Abstract

Chromolaena odorata referred to as Kirinyuh leaves, contains tannins, phenols, flavonoids, saponins, and steroids, which possess antibacterial properties against several pathogenic bacteria in humans, including Staphylococcus aureus, Escherichia coli, and Candida albicans. This investigation aimed to assess the moderate efficacy of the N-Hexan cream derived from Chromolaena odorata L. against Grade IIA burns in male Wistar rats. The research employed a laboratory experimental approach, encompassing the creation of an N-hexane extract from Chromolaena odorata L. and the formulation of various burn cream preparations of 20%, 25%, and 30% concentrations. Multiple tests are conducted: organoleptic assessment, homogeneity evaluation, and testing of pH, spreadability, adhesion, and burn. The research analysis employed a one-way ANOVA followed by the LSD test. The most effective dose for hastening burn wound healing is a 30% concentration of n-Hexan extract, resulting an average healing rate of 79%. The ANOVA test outcomes revealed a significant value of 0.000 (≤ 0.05) indicating a statistically significant difference in burn wound healing by day 21. The findings indicate that the N-Hexan extract from Chromolaena odorata L, exhibits a capacity to expedite the healing of burn wounds in male Wistar rats, as evidenced in both the 25% and the 30% concentration group.  
PDX1-E178G Mutation: Its Impact on Protein Structure and Insulin Gene Regulation in the Cause of Type-2 Diabetes Mellitus Ningrum Wahyuni; Melviana Lubis
Muhammadiyah Medical Journal Vol. 6 No. 2 (2025): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.6.2.110-119

Abstract

Background: Pancreatic and duodenal homeobox 1 (PDX1) is a key transcription factor for pancreatic β-cell differentiation and insulin gene regulation. Mutations in PDX1, such as E178G, have been linked to monogenic diabetes, including MODY4. Understanding the structural and functional consequences of these mutations is critical for advancing diagnostic and therapeutic strategies. Methods: This study employed an in silico approach to assess the impact of the E178G missense mutation on PDX1. Bioinformatics tools were used to evaluate physicochemical properties, secondary and tertiary structure, residue-level interactions, and subcellular localization. Wild-type and mutant models were compared using ProtParam, PSIPRED, SWISS-MODEL, PyMOL, and DeepLoc. Results: The E178G mutation did not affect the overall structure or nuclear localization of PDX1. However, secondary structure prediction revealed a localized decrease in α-helix stability near the mutation site. Tertiary structure modeling and visualization indicated the loss of key polar interactions, which may weaken the DNA-binding capacity of the homeodomain. Discussion: Although nuclear localization remains intact, disruption of structural integrity within the homeodomain suggests impaired transcriptional activity. This supports the hypomorphic nature of the E178G variant, which may lead to partial β-cell dysfunction. The findings are consistent with previous reports linking similar PDX1 mutations to MODY4 phenotypes. Conclusion: The E178G mutation in PDX1 is predicted to cause subtle but functionally relevant structural changes, potentially impairing its role in insulin gene regulation. These results reinforce the value of in silico analysis in understanding the pathogenic mechanisms of genetic variants and guiding precision medicine in monogenic diabetes.
Co-Authors Bayu Ariatama Ekawaty Suryani Mastari Emilia Putri Tarigan Farhah Kamilatun Nuha Fitri Aidani Ulfa Harahap Hendri Meirialdi Indah Afriwanty Simatupang Januarisman Andrian Saragih Luthvia Luthvia Melviana Lubis Meriani HS Noradina Wan Tisya Muhaira Wan Tisya Muhaira Widia Maulida