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All Journal Jurnal Indah Sains dan Klinis
Muhammad Gunawan
Program Studi Farmasi, STIKes Indah Medan
Dentistry Health Professions Medicine & Pharmacology Nursing

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Pembuatan Hidrogel Berbasis Mikrokristal Selulosa Daun Nanas (Ananas comosus L. Merr) dengan Variasi Volume Glutaraldehid Muhammad Gunawan; Nanda Lestari
Jurnal Indah Sains dan Klinis Vol 1 No 1 (2020): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v1i1.3

Abstract

Pineapple leaves natural fibers contain lignin, hemicellulose, and cellulose. The cellulose content of pineapple leaves is around 69.5% -71.5%. Cellulose-derived microcrystals can be used in the pharmaceutical field as binders in tableting formulations. The research objective was to determine whether pineapple leaves can produce microcrystals, microcrystals can be used in the manufacture of hydrogels and to determine variations in the volume of glutaraldehyde that can affect hydrogels. Experimetal researchbegan with delignification with 4% NaOH, immersed for 1 hour and heated, washed with distilled water until neutral pH and blended with 2.7% NaOH, 7.9% acetic acid, NaOCl until white, heated, the residue was taken and drained. , soaked in 1 N HCl, reheatedfor 2 hours, re-stirred and blended until smooth. Cellulose hydrogel was dissolved in 8.5% NaOH and added with glutaraldehyde in various volume variations. Cellulose and hydrogel microcrystals were characterized by visual, swelling ratio test, FTIR, SEM and XRD. The yield of microcrystalline cellulose was 22%, white, homogeneous. Cellulose and hydrogel microcrystals contain O-H (3800-2700 cm-1), C-H (3000-2850 cm-1) and C-O (1300-800 cm-1) groups. Microcrystalline cellulose can be made from pineapple leaves, hydrogel formation is influenced by variations in the volume of glutaradehydeand the highest and lowest swelling ratios are 400% and 12.5%, respectively.
Penetapan Kadar Zink dalam Ikan Tongkol yang Beredar di Pasar Sei Sikambing Secara Spektrofotometri Sinar Tampak Muhammad Gunawan; Ucha Gustamayanti
Jurnal Indah Sains dan Klinis Vol 1 No 1 (2020): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v1i1.4

Abstract

Tuna, a seafood product often consumed by the public, has a high protein content and omega 3 fatty acids. The micro zinc mineral is needed for the synthesis and degradation of biomolecules and the role of enhancing the immune system. Zinc reacts with ditizone in a red base. Research to determine zinc content in raw, fried, steamed, and grilled tuna. Samples were taken purposively at the Sei Sikambing Medan traditional market, determination of levels using visible spectrophotometry, and digestion with a solution of ditizone in alkaline. Method validation parameters include accuracy, precision, and sensitivity. Percent recovery of 100.50%, RSD 0.95 %, LOD 0.620 μg/ml, and LOQ 2.066 μg/ml. The zinc levels of raw, steamed, fried, and grilled tuna were 22.214 mg, 22.063 mg, 22.3384 mg, and 22.234 mg per 100 g, respectively. ANOVA test, there is a significant difference in the acquisition of zinc levels in raw tuna, steamed tuna, grilled tuna, and fried tuna. The method used is quite accurate. The zinc content of raw, fried, grilled tuna was higher than that of steamed, but there was no real difference
Penetapan Kadar Zink Ikan Lele (Clarias batrachus) dari Pasar Sei Sikambing secara Spektrofotometri Sinar Tampak Muhammad Gunawan; Rahmad Hidayat
Jurnal Indah Sains dan Klinis Vol 2 No 2 (2021): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v2i2.22

Abstract

Clarias batrachus is one of the commercially cultivated freshwater fish species in Indonesia, especially in North Sumatra. Nutrinya content of protein, fat, minerals, carbohydrates, and water. Minerals play an important role in metabolic processes that ensure the maintenance of body functions at the cellular, tissue and organ levels. The research was aimed at determining the zinc content of raw, steamed, grilled, and fried catfish by using visible light spectrophotometry method after destruction and adding alkaline dithizone solution. Clarias batrachus samples were taken purposively from the traditional market of Sei Sikambing Medan. Method validation includes accuracy, precision, and sensitivity. The results show that it is accurate with accuracy, precision, limit of detection and quantitation of 99.95% each; 1.06%; 0.620 g/ml; 2.066 g/ml. ANOVA test showed no significant difference in zinc content of raw, steamed, grilled, and fried catfish.
Tablet Kompresi Langsung Ekstrak Etanol Daun Salam (Syzygium polyanthum) Muhammad Gunawan; Suprianto; Samran; Cut Fatimah; Debi Melani; Sumardi
Jurnal Indah Sains dan Klinis Vol 2 No 3 (2021): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v2i3.31

Abstract

Indonesia's natural wealth that is efficacious in suppressing cholesterol, hypertension, diarrhea, gastritis and blood sugar is one of the bay leaves (Syzygium polyanthum Wight.). Tablets are preparations that are practical to use, easy to produce, pack, and distribute. The research was directed to make tablets of bay leaf ethanol extract (EEDS) by direct compression. EEDS tablets were made into four formulas with various fillers of lactose and Avicel PH 102, each 200 mg : 135 mg A); 250 mg : 105 mg (B); 300 mg : 55 mg (C); and 350 mg : 5 mg (D). The study showed that all formulas met the preformulation test requirements and tablet evaluation, D as the best formula. EEDS is made into tablets by direct compression.
Evaluasi Stabilisator Agar-Agar dan CMC Sediaan Sirup Markisa Berastagi Suprianto; Muhammad Gunawan; Melati Yulia Kusumastuti; Cut Fatimah; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 3 No 1 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/b1pzvs47

Abstract

Fruit syrup is made from a sugar solution, the taste and aroma are determined by the freshness of the fruit. Fruit commonly used in making syrup has an attractive color, aroma and distinctive taste. Passion fruit (Passiflora edulis Sims.) has a distinctive taste and aroma, so it is widely processed into syrup. This study was to evaluate CMC and Agar-Agar stabilizers in the passion fruit syrup formula. Evaluation includes color, appearance, texture, taste and aroma and hedonic tests are carried out. The results showed that there were significant differences in the color, appearance, texture, taste and aroma of passion fruit syrup. Stabilizers CMC and Agar-Agar make the color, texture and appearance of the syrup better and more attractive. The result of hedonic test for ideal syrup concentration is S3 with 4 g of Agar and 6 g of CMC. The higher the concentration of CMC and Agar, the greater the viscosity of the syrup. The concentration of CMC and Agar-agar in a mixture of fruit juices gave significantly different effects on color, texture, appearance, taste and aroma
Evaluasi Konsentrasi Karboksimetilselulosa Alginat Formula Pasta Gigi Antiseptik Ekstrak Etanol Daun Seledri (Apium graveolens L.) Samran; Suprianto; Muhammad Gunawan; Melati Yulia Kusumastuti
Jurnal Indah Sains dan Klinis Vol 3 No 1 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i1.45

Abstract

Maceration of Celery leaves using 96% ethanol solvent was used to make the extract. Toothpaste is formulated with carboxymethylcellulose and alginate binders. The active ingredient in the form of ethanol extract from Celery leaves has the potential for antibacterial. This study was to evaluate the concentration of carboxymethylcellulose alginate in the preparation of antiseptic toothpaste of ethanol extract from Celery leaves. Evaluation of production results consisted of organoleptic, homogeneity, spreadability, foam formation, acidity and viscosity. The higher the concentration of carboxymethylcellulose, the lower the foam and spreadability and the higher the viscosity, while the alginate concentration is the opposite. Carboxymethylcellulose alginate affects the evaluation parameters of antiseptic toothpaste preparations ethanol extract of Celery leaves
Analisis Biaya Efektif Terapi Diare Pasien Rawat Inap RS Putri Hijau Medan Muhammad Gunawan; Suprianto; Melati Yulia Kusumastuti; Sumardi; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 3 No 1 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i1.46

Abstract

Diarrhea is characterized by the excretion of liquid stools with a frequency of three or more times a day, due to gastrointestinal infections due to food and water contaminated with microorganisms, or directly from humans due to poor sanitation. This study was to determine the characteristics of diarrhea patients, treatment and cost-effectiveness of treatment at Putri Hijau Hospital, Medan. The non-experimental research is descriptive and retrospective in nature of financial patient medical records from July to December 2018. Cost Effectiveness Analysis as a method of cost analysis. The characteristics of the patients obtained were 14 women (46.670%) and 16 men (53.33%). The effectiveness of New Diatabs (92.30%) and New Diatabs Metronidazole (94.11%). The cost of therapy with New Diatabs is Rp. 1,547,771/patient and New Diatabs Metronidazole is Rp. 1,562,590/patient. Average cost-effectiveness New Diatabs Rp. 190,345 and New Diatabs Metronidazole Rp. 183,060, so it is concluded that the cost-effective therapy is the use of the combination of New Diatabs Metronidazole compared to New Diatabs.
Co-Authors Cut Fatimah Debi Meilani Debi Melani Melati Yulia Kusumastuti Nanda Lestari Rahmad Hidayat Samran, Samran Sumardi Suprianto Suprianto Ucha Gustamayanti