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All Journal Jurnal Kedokteran Diponegoro Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Meita Hendrianingtyas
Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Carbapenem Susceptibility Rate Against Gram-Positive and Gram-Negative Bacteria and Its Correlation with Consumption George Arthur Mantiri; Rheza Paleva Uyanto; Meita Hendrianingtyas
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2207

Abstract

Antibiotic susceptibility is significant in patient management and needs close monitoring. This study aims to evaluate the Carbapenem susceptibility profiles and correlation between Carbapenem consumption and susceptibility of the most frequent isolates from blood, sputum, and urine in 2020–2022 from the non-intensive inpatients. The proportion of males and females was 54% and 46%, with the median age group of males and females both being 65-74 years. Higher Meropenem susceptibility was shown in urine isolates of female patients. Lower susceptibility to Meropenem was shown in 2021 compared to 2020 and 2022. Lower susceptibility was shown in isolates from sputum compared to blood and urine. The three-year susceptibility of Carbapenem was decreased compared to 3 years before. The susceptibility of E.coli and S.aureus to Meropenem showed relatively high proportions 95% and 88%, compared to K.pneumoniae (46%), A.baumanii (30%), P.aeruginosa (29%), and others.  The susceptibility of isolates from non-intensive-care inpatients in 2020-2022 showed lower rates compared to the hospital-wide and the previous three years' rates. Meropenem consumption was highest compared to Imipenem with inhibitor and Doripenem. The susceptibility of Gram-negative rods to Meropenem showed higher proportions (58.9%) compared to Gram-positive cocci (26.2%). Carbapenem susceptibility was decreased, along with increased Carbapenem consumption but no significant statistical correlation between the susceptibility rates and the monthly defined daily dose.
CORRELATION BETWEEN LIVER TRANSAMINASE ENZYME AND LEUKOCYTE COUNT IN TUBERCULOSIS PATIENTS WHO RECEIVED ANTI-TUBERCULOSIS DRUG THERAPY Kayla Navazia Marlie; Edward Kurnia Setiawan Limijadi; Meita Hendrianingtyas; Dwi Retnoningrum
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 3 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i3.46561

Abstract

Background: While effective in treating the disease, anti-tuberculosis drugs can also potentially harm the liver. Monitoring liver health using the transaminase enzyme and leukocyte counts can help in the early detection and prevention of such damage in tuberculosis patients. Objectives: The aim of the study was to determine the correlation between transaminase enzyme levels and the leukocyte count in patients with tuberculosis who took anti-tuberculosis drugs. Methods: This research was an observational analytical study with a cross-sectional approach. It used medical record data from TB patients who met the inclusion and exclusion criteria for anti-tuberculosis drug therapy at the medical records installation. Results: Forty-four samples were included in the research. The levels of aspartate transaminase (AST), alanine transaminase (ALT), and leukocyte count were 30 IU/L, 19.5 IU/L, and 9.35x103/µL. The Spearman correlation test showed no correlation between AST and ALT levels and leukocyte counts, with p-values of 0.585 and 0.337. Conclusion: There was no correlation between AST and ALT levels and leukocyte counts in tuberculosis patients undergoing anti-tuberculosis drug therapy.
CORRELATION BETWEEN STRESS HORMONE, INFLAMMATORY MARKER, AND ANTIBODY LEVELS IN COVID-19 PATIENTS Dwi Retnoningrum; Meita Hendrianingtyas; Rebriarina Hapsari; Setyo Gundi Pramudo; Edward Kurnia Setiawan Limijadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 3 (2026)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i3.2771

Abstract

Coronavirus disease-19 (COVID-19) is an infection that causes physical and psychological stress. Cortisol and prolactin are hormones that have been studied in association with infectious states. Viral infections trigger the production of acute-phase proteins and antibodies essential for viral elimination. This study aimed to prove the correlation between stress hormone levels and inflammatory markers and antibodies in COVID-19 patients. A cross-sectional approach was employed in this study, with a target population of patients with moderate-to-severe COVID-19. Cortisol, prolactin, and specific antibodies were quantified via ELISA, while CRP and procalcitonin levels were measured using immunoturbidimetric and immunofluorescence assays. Additionally, anti-SARS-CoV-2 antibodies were evaluated using the ECLIA principle. Statistical analysis was performed using the Spearman rank correlation test. Fifty-six subjects were included in this study. The study found correlations between cortisol and prolactin levels and CRP (p=0.007, r=0.357; p=0.132, r=0.204) and procalcitonin (p=0.006, r=0.365; p=0.315, r=0.137). The correlations between cortisol and prolactin levels and IgM were p=0.163, r=-0.189; and p=0.299, r=-0.141. The correlations between cortisol and prolactin levels and IgG were p=0.017, r=-0.317, and p=0.207, r=-0.171. There is a weak positive correlation between cortisol levels and CRP and procalcitonin levels. There is a weak negative correlation between cortisol levels and anti-SARS-CoV-2 IgG.
Co-Authors Dwi Retnoningrum Edward Kurnia Setiawan Limijadi George Arthur Mantiri Kayla Navazia Marlie Rebriarina Hapsari Rheza Paleva Uyanto Setyo Gundi Pramudo