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All Journal Jurnal Kedokteran Diponegoro
Dwi Retnoningrum
Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang
Medicine & Pharmacology

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Effects of Andrographis paniculata Leaf Extract on C-Reactive Protein and Serum Ferritin in Lipopolysaccharide-Induced Sepsis Model Rat Rezya Salsabela; Nyoman Suci Widyastiti; Dwi Retnoningrum; Ariosta Ariosta; Neni Susilaningsih
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 3 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i3.37645

Abstract

Background: C-reactive protein (CRP) and ferritin are acute-phase reactants that have demonstrated association with the severity of a variety of inflammation-mediated illnesses, including infection and sepsis. Sambiloto (Andrographis paniculata) leaf is traditionally used as an anti-inflammation and anti-bacterial herb. Sambiloto leaf extract possesses anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, and antioxidant activitiesObjective: To evaluate the effect of Sambiloto leaf extract (Andrographis paniculata) on inflammation biomarker (CRP and serum ferritin) in a rat model of sepsis-induced by lipopolysaccharide (LPS).Methods: This research was a true experimental study with a post-test-only control group design. Twenty five male Wistar rats were randomly divided into 5 groups consisting of a healthy control (HC), Negative control (NC), Treatment 1 (T1) Sambiloto 200mg/kgBW, T2 Sambiloto 400mg/kgBW, T3 Sambiloto 500mg/kgBW). Sambiloto leaf extract was given on days 8-21 and LPS 5mg/kgBW was injected intraperitoneal on day 22. On the 25th day, blood was drawn and  CRP and serum ferritin levels were analyzed using ELISA method. The data were analyzed using One-Way ANOVA and Kruskal Wallis test.Results: The mean CRP levels of HC, NC, T1, T2,T3 were 7.72 ± 2.53; 8.12 ± 1.08; 5.22 ± 1.71; 6.40 ± 1.19; 5.14 ± 1.37 ng/dl respectively. The mean serum ferritin level of HC, NC, T1, T2, T3 were 293.60 ± 66.53; 601.20 ± 100.17; 433.40 ± 194.65; 331.60 ± 75.97; 318.00 ± 69.64 ng/dl respectively. There were differences in CRP levels in groups T1(p=0.012) and T3(p=0.010), serum ferritin levels in groups T2(p=0.014) and T3(p=0.008) to the control group.Conclusion: Sambiloto (Andrographis paniculata) leaf extract  has anti-inflammatory effects in the rat model of sepsis.
CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO AND LIPID PROFILE IN TYPE-2 DIABETES MELLITUS Nadwa Izza Azuma Arifin; Banundari Rachmawati; Meita Hendrianingtyas; Dwi Retnoningrum
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 2 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i2.46358

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease that can cause low-grade chronic inflammation related to insulin resistance. Recently, neutrophil to lymphocyte has become a potential marker of chronic inflammation. An abnormal lipid profile occurs due to lipotoxicity from insulin resistance. Objective: To prove the correlation between NLR and lipid profiles in T2DM patients. Methods: An analytic observational study used a cross-sectional approach to 45 medical records of T2DM patients who received treatment at Nasional Diponegoro Hospital Semarang. This study was conducted from October to November 2022. Data was collected by using consecutive sampling. Analysis of the correlation between NLR and lipid profiles used spearman’s correlation test. Results: The correlation between NLR and HDL cholesterol levels was p=0.035, r=-0.315. The correlation between NLR and cholesterol, LDL cholesterol, and triglyceride levels was p = 0.061, r = -0.281; p = 0.170, r = -0.208; p = 0.563, r = -0.089, respectively. Conclusion: There was a weak negative correlation between NLR and HDL cholesterol levels in T2DM patients, but there was no correlation between NLR and other lipid profiles. 
CORRELATION BETWEEN LIVER TRANSAMINASE ENZYME AND LEUKOCYTE COUNT IN TUBERCULOSIS PATIENTS WHO RECEIVED ANTI-TUBERCULOSIS DRUG THERAPY Kayla Navazia Marlie; Edward Kurnia Setiawan Limijadi; Meita Hendrianingtyas; Dwi Retnoningrum
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 3 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i3.46561

Abstract

Background: While effective in treating the disease, anti-tuberculosis drugs can also potentially harm the liver. Monitoring liver health using the transaminase enzyme and leukocyte counts can help in the early detection and prevention of such damage in tuberculosis patients. Objectives: The aim of the study was to determine the correlation between transaminase enzyme levels and the leukocyte count in patients with tuberculosis who took anti-tuberculosis drugs. Methods: This research was an observational analytical study with a cross-sectional approach. It used medical record data from TB patients who met the inclusion and exclusion criteria for anti-tuberculosis drug therapy at the medical records installation. Results: Forty-four samples were included in the research. The levels of aspartate transaminase (AST), alanine transaminase (ALT), and leukocyte count were 30 IU/L, 19.5 IU/L, and 9.35x103/µL. The Spearman correlation test showed no correlation between AST and ALT levels and leukocyte counts, with p-values of 0.585 and 0.337. Conclusion: There was no correlation between AST and ALT levels and leukocyte counts in tuberculosis patients undergoing anti-tuberculosis drug therapy.
Co-Authors Ariosta Ariosta Banundari Rachmawati Edward Kurnia Setiawan Limijadi Kayla Navazia Marlie Meita Hendrianingtyas Meita Hendrianingtyas Nadwa Izza Azuma Arifin Neni Susilaningsih Nyoman Suci Widyastiti Rezya Salsabela