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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Doktin Medika
Nabila Risma Anjana
Universitas Muhammadiyah Malang
Health Professions Medicine & Pharmacology Public Health

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Effectiveness Of Watermelon (Citrullus lanatus) Red Flesh Extract On Reducing Coronary Artery Foam Cells and Thinning Of The Aortical Intima In Wistar Rats (Rattus norvegicus strain Wistar) Atherosclerosis Model Mochamad Bahrudin; Dian Yuliartha Lestari; Nabila Risma Anjana; Tiara Lastari
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 19 No. 2 (2023): December 2023
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol19.SMUMM2.32403

Abstract

Introduction: Atherosclerosis (AS) is a process of narrowing of the lumen of arteries due to progressive plaque buildup. Foam Cell and plaque appear as a result of lipoprotein metabolism disorders which result in inflammatory reactions. The incidence of AS in the world is increasing, resulting in various complications that can lead to death. Lycopene is contained in the red flesh of watermelon, which is an antioxidant that can control free radicals and can reduce the risk of AS. Objective: To determine the effectiveness of watermelon (Cittrulus lanatus) red flesh extract on reducing coronary artery foam cells and thinning of the aortic intima in Wistar rats (Rattus norvegicus strain Wistar) atherosclerosis model. Method: This research was an experimental study (true experimental) using the Post Test Only Control Group Design method, which measures the number of coronary artery foam cells and the thickness of the aortic intima in Wistar rats (five groups) after administration of a hypercholesterolemic diet and watermelon red flesh extract at a dose of 250,500,750 mg /kgBW. Data analysis was carried out using One-Way ANOVA and Post Hoc Bonferroni tests. Results: The One-Way ANOVA statistical test showed results of 0.020 for foam cells and 0.008 for thickness of the intimal tunica, which means that there was a real influence of watermelon red flesh extract on decreasing foam cells and significant thinning of the intimal tunica in the treatment group. Furthermore, the Post Hoc Bonferroni test showed that the dose of 750 mg/kgBW had the most effect on reducing foam cells (p=0.046) and thinning the intima (p=0.015). Conclusion: Watermelon (Citrullus lanatus) red flesh extract at a dose of 750 mg/kgBW has a significant effect on reducing the number of foam cells and thinning of the aorta of the Wistar rat model of atherosclerosis.
Improving Workers' Understanding Of Osteo Arthritis Disease Due To Work For Tea Leaf Picking Workers At Ptpn 12 Lawang Mochamad Bahrudin; Diah Hermayanti; Dyatmika Syifa Kirana; Nabila Risma Anjana; Tiara Lastari
DokTIn MEDIKA Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2026): August 2026
Publisher : Universitas Muhammadiyah Malang

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Abstract

Background. Osteoarthritis is a type of arthritis that is most often suffered by sufferers compared to other types of arthritis. It is estimated that there are two million elderly people in Indonesia who are disabled due to osteoarthritis. This figure is quite high and requires special attention because osteoarthritis often damages joints and causes movement disorders in sufferers. Along with the length of time working as a tea picker and increasing age, the incidence of osteoarthritis will continue to increase. Objective. Increase knowledge about osteoartritis in tea leaf pickers in Wonokerto Lawang tea plantations, Malang Regency.Method. Activities carried out with direct face-to-face counseling. Before and after the activity, questionnaires were given to see the initial knowledge and after the counseling and the results were analyzed Results. One person (2%) aged less than 40 years complained of OA and two people (6%) aged more than 40 years complained of OA. The participant's level of knowledge was 100%, they did not understand OA. The pre-test score was 72% very poor, 26% poor and only 2% quite poor. The post test results of the level of knowledge greatly increased from not understanding to understanding. 2% of the knowledge scores were good and 96% of the scores were very good with a p value <0.05 (0.000) which means very significant.Conclusion. The knowledge of workers at the Wonosari Tea Plantation about OA disease increased after the education was carried out.Keywords: Extension, osteoartritis, Wonokerto Lawang tea plantations
Co-Authors Diah Hermayanti Dian Yuliartha Lestari Dyatmika Syifa Kirana Mochamad Bahrudin Tiara Lastari Tiara Lastari