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All Journal Fullerene Journal of Chemistry Makara Journal of Science Borneo Journal of Pharmacy
Arfan, Aulia Rhamdani
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Chemistry Medicine & Pharmacology

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Synthesis, Molecular Characteristics, and Antibacterial Assessment of Marine Hydroid Aqueous Extract-Based Silver Bio-nanoparticles Mandey, Fredryk; Arfan, Aulia Rhamdani; Arfah, Rugaiyah Andi
Makara Journal of Science Vol. 28, No. 1
Publisher : UI Scholars Hub

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Abstract

This investigation aims to synthesize, analyze the molecularity, and test the ability of bacterial inhibition capability of silver nanoparticles that have been synthesized by simply mixing silver nitrate and aqueous extracts of marine natural products with and without the addition of amylum as a stabilizing agent. This research, with and without the addition of amylum as a stabilizing agent, obtained 39.0 and 55.2 mg of solids of round-shaped morphology silver nanoparticles with diameters of 87.9 and 103.0 nm., respectively. In addition, the antibacterial testing assay against Staphylococcus aureus and Escherichia coli showed some considerably good results. S. aureus with the addition of amylum had inhibition zone diameters of 8.55 and 7.45 mm, whereas without the addition of amylum had inhibition zone diameters of 7.82 and 7.22 mm. E. coli with the addition of amylum had inhibition zone diameters of 7.0 and 7.65 mm, whereas E. coli without the addition of amylum had inhibition zone diameters of 7.82 and 7.22 mm.
Potential of Moringa oleifera Seeds as a Natural Coagulant for Turbidity and LAS Removal from Detergent Wastewater Arfan, Aulia Rhamdani; Irawati, Utami; Indah, Rahma; Hikmah, Nawwal
Jurnal Kimia Fullerene Vol 10 No 2 (2025): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v10i2.748

Abstract

Detergent wastewater contains high levels of surfactants, particularly Linear Alkylbenzene Sulfonate (LAS), which are persistent and harmful to aquatic ecosystems. This study evaluated the potential of Moringa oleifera seed extract (MOS) as a natural coagulant for detergent wastewater, compared with alum as a synthetic coagulant. The coagulation process was carried out using the jar test method at varying dosages (100–1500 mg/L) and pH levels (4–9). Turbidity was measured following SNI 06-6989.25-2005, while LAS concentration was analysed using the Methylene Blue Active Substances (MBAS) method. Results showed that MOS achieved optimum performance at 1500 mg/L and pH 4, with a turbidity removal efficiency of 94.96% (final turbidity 4.76 NTU) and LAS removal efficiency of 88.94% (final concentration 0.58 mg/L). In comparison, alum reached its optimum at 200 mg/L and pH 6, with lower LAS removal efficiency. Validation with wastewater samples stored for 1–3 nights indicated that MOS maintained consistent performance, while alum showed fluctuating results. An in-silico docking study further confirmed the molecular interaction between LAS and MOS proteins, with a binding energy of –4.8 kcal/mol, supporting the observed experimental results. These findings demonstrate that MOS is a promising, low-cost, and environmentally friendly alternative to alum for detergent wastewater treatment.
Molecular Docking and In Silico Evaluation of Beluntas (Pluchea indica) Phytochemicals as Potential Angiotensin-Converting Enzyme Inhibitors for Hypertension Treatment Rasjava, Achmad Ramadhanna’il; Akbar, Nabila Hadiah; Arfan, Aulia Rhamdani; Wardani, Dyah Ayu Pramoda; Putra, Aditya Maulana Perdana; Muslimawati, Khoirunnisa; Buih, Putri Helena Junjung; Fakih, Taufik Muhammad
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.9706

Abstract

Hypertension remains a major global health concern due to its high prevalence and strong association with cardiovascular diseases and kidney failure. A key component of blood pressure regulation is the Angiotensin-Converting Enzyme (ACE), which catalyzes the conversion of Angiotensin I into the vasoconstrictor Angiotensin II, making it a primary target for antihypertensive drugs. Although synthetic ACE inhibitors such as ramiprilat are effective, their use is often associated with adverse effects, highlighting the need for safer alternatives. This study employs molecular docking and in silico analysis to evaluate the potential of phytochemicals from beluntas (Pluchea indica) as natural ACE inhibitors. A total of 110 phytoconstituents were screened for pharmacokinetic properties using ADMET analysis, leading to the selection of 20 ligands for docking simulations. Among these, 4,5-di-O-caffeoylquinic acid exhibited the highest binding affinity (-9.409 kcal/mol), followed by di-O-caffeoylquinic acid (-8.984 kcal/mol) and quercetin-3-O-β-D-galactopyranoside (-8.372 kcal/mol). These compounds demonstrated stronger binding affinities than the ACE natural substrate, Angiotensin I (-7.133 kcal/mol), and the ACE inhibitor, ramiprilat (-8.717 kcal/mol), suggesting their potential as competitive ACE inhibitors. The binding interactions of these compounds were characterized by hydrogen bonding with key catalytic residues (HIS368, GLU368), electrostatic stabilization, and hydrophobic interactions within the enzyme active site. Notably, caffeoylquinic acid derivatives closely mimicked the binding mode of ramiprilat, whereas quercetin glycosides exhibited a distinct interaction pattern, indicating a possible alternative inhibitory mechanism. These findings provide evidence supporting the potential of P. indica phytochemicals as natural ACE inhibitors and warrant further investigation into their therapeutic applications in hypertension management.
Co-Authors Akbar, Nabila Hadiah Arfah, Rugaiyah Andi Buih, Putri Helena Junjung Fredryk Welliam Mandey Hikmah, Nawwal Indah, Rahma Khoirunnisa Muslimawati Putra, Aditya Maulana Perdana Rasjava, Achmad Ramadhanna’il Taufik Muhammad Fakih Utami Irawati Wardani, Dyah Ayu Pramoda