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ISOLATION, IDENTIFICATION AND BIOACTIVITY TEST OF NON POLAR COMPOUNDS ON n-HEXANE EXTRACT OF Haliclona (Reniera) fascigera FROM SAMALONA ISLAND-SPERMONDE ARCHIPELAGO Hafiludin Uli; Alfian Noor; Fredryk Welliam Mandey; Ajuk Sapar
Marina Chimica Acta Vol. 17 No. 2 (2016): Volume 17 No. 2 (2016)
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.779 KB) | DOI: 10.20956/mca.v17i2.1125

Abstract

Isolation, identification and bioactivity test of nonpolar compunds has been conducted on n-hexane extract sponge Haliclona (Reniera) fascigera of the island Samalona, Makassar, South Sulawesi. Isolation techniques consist of maceration, partition, fractionation using 2 steps using vacuum column chromatography and flash column chromatography and also purification step. Identification of isolate was analyzed with TLC, FTIR, GC-MS, and 1H NMR. The research result was obtained isolate as much as 4 mg and clear solid form. FTIR analysis indicate functional group OH, CH­2, CH3, C=O, =CH and C-O. Identification of spot TLC under UV light and spotting solvent show that the spot was active on UV long and short waves and dark brown with cerium sulphate. The results show that isolate A contain aliphatic and alcohol compounds. Bioactivity test results indicate that these isolate A be able to inhibit the growth of bacteria Staphylococus aureus with inhibition zone diameter were 11.60 mm (100 ppm); 10.40 mm (50 ppm); 9.50 mm (25 ppm); 6.50 mm (10 ppm); 6,60 mm (negative control); 17.40 mm (positive control) and against bacteria Escherichia coli with inhibition zone diameter were 6.70 mm (100 ppm); 6,10 mm (50 ppm); 5,90 mm (25 ppm); 5.85 mm (10 ppm); 5,20 mm (negative control); 18.60 mm (positive control).
PEMANFAATAN MEDIA VIDEOGRAFIS SEBAGAI SARANA PROMOSI DALAM RANGKA PENINGKATAN PANGSA PASAR HASIL KERAJINAN PANDAI BESI DI KECAMATAN SANGGALANGI’ KABUPATEN TORAJA UTARA DI MASA PANDEMI COVID-19 Beatrix Saludung; Delvia Datu Padang; Muhammad Kurnia; Fredryk Mandey
Panrita Abdi - Jurnal Pengabdian pada Masyarakat Vol. 6 No. 1 (2022): Jurnal Panrita Abdi - Januari 2022
Publisher : LP2M Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/pa.v6i1.12869

Abstract

This community services program aims to foster the promotion of two groups of blacksmith craftsmen at Sanggalangi district to increase the iron craft products sales, which decreased drastically due to the pandemic Covid-19. The promotion method uses video graphics distributed through social media networks like Instagram, Facebook Market, and WhatsApp. The results showed some increase in the selling of the iron craft from both groups of target blacksmiths. --- Kegiatan pengabdian masyarakat ini bertujuan untuk membantu promosi  kelompok pengrajin pandai besi di Kecamatan Sanggalangi’ menggunakan media teknologi informasi dan komunikasi berbasis media sosial untuk  meningkatkan jumlah penjualannya yang saat ini mengalami penurunan akibat pandemi covid-19. Metode promosi yang digunakan adalah videografis yang hasilnya disebarkan melalui jejaring media sosial seperti: instagram, facebook market, dan WhatsApp. Hasilnya diperoleh peningkatan jumlah penjualan yang cukup baik pada kedua kelompok pengrajin sasaran.
SPECTROSCOPICAL STUDY OF AN ETHER FRACTION ISOLATE FROM STEAM BARK OF “ JATI” (Tectona grandis, L) Fredryk Mandey; Raimundus Chalik; Ismail Ibrahim
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.689 KB) | DOI: 10.22146/ijc.21548

Abstract

This research is aimed to primarily study the spectroscopy of ether fraction of from Jati wood (T. grandis, L). The stem bark of T.grandis, L was firstly extracted undergoes a reflux in methanol solvent. Further, the dried methanol crude extract was extracted with diethyl ether and moreover separated its chemical constituents by using of column chromatography using degraded mixtures of n-hexane - ethyl acetate from 9:1 to 7:3. After a final column chromatography from the E fraction, a white needles crystal with a melting point of 295 - 297.5 °C was resulted. This results was then confirmed undergoes a spectroscopic analysis including UV, FTIR, H-NMR, and Mass spectroscopy to get an acid of 3β-hydroxy-20(29)-lupen-28-oic or commonly known as betulinic acid.
NORARTOCARPETIN, FLAVONE DERIVATIVE FROM LEAVES OF Artocarpus fretessi Nunuk Hariani Soekamto; Nursiah La Nafie; Fredryk Welliam Mandey; Marry Garson
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.788 KB) | DOI: 10.22146/ijc.21551

Abstract

Norartocarpetin (1), together with mulberrin (2) and mulberrokromen (3) were isolated from Artocarpus fretessi (Moraceae). This plant is an endemic species in Indonesia and locally known as ";Kelembi"; or ";Maumbi";. The structure of these compounds were elucidated on the basis of physical and spectroscopic data. Compounds (1) is precursor of compound (2) and (3) in the biogenetic pathway.
A PRELIMINARY QUALITATIVE STUDY OF AN ALKALOID IN THE FRUIT OF TERONG BELANDA (Cyphomandra betacea, Cav) Fredryk Mandey; Mikael Dominggus; Tjodi Harlim
Indonesian Journal of Chemistry Vol 3, No 1 (2003)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (30.454 KB) | DOI: 10.22146/ijc.21898

Abstract

Preliminary studies on Terong Belanda (C. betacea ) have been carried out in this investigation with an aim to examine the presence of an alkaloid in the fruit of Terong Belanda. Several protocols had been done including maceration, extraction, evaporation, separation under column chromatography, crystallization and recrystallization, and testing with series of alkaloid reagent test. Finally one fraction, fraction D, obtaining in white sharp crystals, 96 mg, m.p 117.5 ºC gave positive results to an alkaloid especially from the group of atropine.
AN EFFICIENT SYNTHESIS OF 1,3-BENZODIAZINE-2,4-DIONES ANALOGS Fredryk Mandey
Indonesian Journal of Chemistry Vol 1, No 3 (2001)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (64.874 KB) | DOI: 10.22146/ijc.21937

Abstract

An investigation of base promoted reaction of phenylanthranilate and isocyanate has been carried out. The reaction between phenylanthranilate (11) and phenylisocyanate and n-butylisocyanate gave remarkable yields of corresponding 1,3-Benzo-diazine-2,4-diones (12a) and (12b).
Implementasi Kegiatan Kuliah Kerja Nyata Untuk Optimalisasi Pengembangan Pariwisata Berbasis Masyarakat Di Kelurahan Pangli, Kecamatan Sesean, Kabupaten Toraja Utara Fredryk Mandey; Pranata, Indra; Pilla, Marselin; Palullungan, Jummi; B.A. Padang, Adrian; Khezia A.D, Alda; Patrecya P, Angela; Wina, Liong; Malton Patasik, Yorgi
JDISTIRA - Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Vol. 3 No. 2 (2023)
Publisher : Yayasan Rahmatan Fidunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jdt.v3i2.569

Abstract

Program pengembangan pariwisata berbasis masyarakat dalam bentuk kegiatan kuliah kerja nyata tematik telah dilaksanakan di Kelurahan Pangli, Kecamatan Sesean, Kabupaten Toraja Utara dengan tujuan meningkatkan kesejahteraan masyarakat melalui upaya peningkatan kualitas kawasan wisata . Program ini meliputi 3 (tiga) aktivitas utama, yakni: promosi dan peningkatan daya saing objek dan destinasi wisata; serta memperbaiki dan meningkatkan kualitas kesehatan dan lingkungan hidup masyarakat. Hasil yang diperoleh antara lain: video dan buku profil Kelurahan Pangli, Bahasa Indonesia, aktivitas penyukuhan masyarakat untuk meningkatkan deraja kesehatannya, serta mencegah dan menanggulangi masalah kesehatan Stunting bagi anak-anak bayi dan balita; selanjutnya kebun percontohan yang ditanami tanaman obat; serta keikutsertaan dalam gerakan Jumat Bersih. Semua program kerja yang direncanakan dapat dilaksanakan dengan baik. Untuk memelihara keberlanjutan program kerja maka disarankan agar  mahasiswa kuliah kerja nyata berikutnya bekerjasama dengan pemerintah keluarahan Pangli dapat melanjutkan dan menyempurnakan kegiatan yang belum tuntas.
Synthesis, Molecular Characteristics, and Antibacterial Assessment of Marine Hydroid Aqueous Extract-Based Silver Bio-nanoparticles Mandey, Fredryk; Arfan, Aulia Rhamdani; Arfah, Rugaiyah Andi
Makara Journal of Science Vol. 28, No. 1
Publisher : UI Scholars Hub

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Abstract

This investigation aims to synthesize, analyze the molecularity, and test the ability of bacterial inhibition capability of silver nanoparticles that have been synthesized by simply mixing silver nitrate and aqueous extracts of marine natural products with and without the addition of amylum as a stabilizing agent. This research, with and without the addition of amylum as a stabilizing agent, obtained 39.0 and 55.2 mg of solids of round-shaped morphology silver nanoparticles with diameters of 87.9 and 103.0 nm., respectively. In addition, the antibacterial testing assay against Staphylococcus aureus and Escherichia coli showed some considerably good results. S. aureus with the addition of amylum had inhibition zone diameters of 8.55 and 7.45 mm, whereas without the addition of amylum had inhibition zone diameters of 7.82 and 7.22 mm. E. coli with the addition of amylum had inhibition zone diameters of 7.0 and 7.65 mm, whereas E. coli without the addition of amylum had inhibition zone diameters of 7.82 and 7.22 mm.
Extraction, Fractionation, And Antioxidant Examination Of Polyfloral Honey Originated From Bone Prefecture South Sulawesi Province Mandey, Fredryk W; Handayani, Endah; Nanda, Wahyuni Eka; Noor, Alfian
Indonesian Journal of Chemical Research Vol 7 No 1 (2019): Edisi Bulan Juli (Edition For July)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2019.7-fmd

Abstract

The aim of this research to isolate and identify and to test the antioxidant activity of extract and fraction of polyfloral honey originated from Bone regency, South Sulawesi. The results showed that methanol gave results in flavonoid, tannin, saponnin, steroid, and alkaloid with IC50 value of DPPH method of 683,153 µg/mL. DCM extract gave positive results for tannin, steroid and alkaloid with IC50 values of 701,743 µg/mL. n-hexane extract positively contains tannin and alkaloid with IC50 1709,536 µg/Ml, water extract positevely contains tannin, sapponin steroid, alkaloid with IC50 value 1698,345 µg/mL. Pure honey contains all aspects tested with IC50 values 2826,471 µg/mL. This showed extracts and sample have weak antioxidant activity.
Synthesis, Molecular Characterization, and Antibacterial Testing of Silver–Cadmium Bimetallic Bionanoparticles Prepared from the Sidaguri (Sida rhombifolia L.) Extract Mandey, Fredryk; Rangga Bua, Anita Rahelea; Rahayu, Ismi Sri; Permatasari, Nur Umriani
Makara Journal of Science Vol. 29, No. 3
Publisher : UI Scholars Hub

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Abstract

Herein, we successfully synthesized, characterized, and examined the antibacterial activity of silver–cadmium bimetallic bionanoparticles prepared by mixing the aqueous extract of Sidaguri (Sida rhombifolia L.) and mixtures of silver nitrate and cadmium nitrate (yield = 0.2035 g). Ultraviolet–visible spectroscopy, Fourier transforms infrared spectroscopy, X-ray diffraction, scanning electron microscopy–energy dispersive X-ray spectroscopy, and particle-size analysis, revealed that the products exhibited a maximum absorption wavelength of 427.5 nm with an absorbance intensity of 0.790; a face centered cubic structure; Ag and Cd mass percentages of 98.52% and 1.28%, respectively; an average molecular diameter of 43.8 nm, and a polydispersity index of 0.573. The bimetallic nanoparticles were tested as an antibacterial agent against Staphylococcus aureus and Escherichia coli. They exhibited inhibition zone diameters of 9.2 and 10 mm for E. coli and S. aureus, respectively.