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All Journal Journal of Food Security and Agroindustry ROCE : Jurnal Pertanian Terapan
Dodi Iskandar
Politeknik Negeri Pontianak
Agriculture, Biological Sciences & Forestry Other

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Pengaruh Ukuran Partikel Ampas Kelapa dan Rasio Kacang Tanah pada Karakteristik Snack bar Tinggi Serat Siti Aisyah; Yuliana Erning Indrastuti; Donor Utomo Muhammad Susilo; Dodi Iskandar; Suharyani Amperawati
Journal of Food Security and Agroindustry Vol. 4 No. 2 (2026): JUNE
Publisher : PAKIS JOURNAL INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/jfsa.v4i2.979

Abstract

Coconut dregs are a byproduct of the coconut oil processing industry, and their utilization as food is limited, even though they still contain crude fiber. This study aimed to analyze the effects of the size and ratio of peanuts and coconut dregs on the physical (color), chemical (water content and crude fiber), and sensory characteristics of snack bars. This study used a Completely Randomized Design (CRD) with two factors: the first factor is size of the coconut dregs (coarse and fine). The second factor was the ratio of coconut dregs to peanuts (15:85, 20:80, and 25:75 g/g). The analysis carried out on the snack bar was water content, fiber content, color (L*, a*, b*, whiteness index and browning index), sensory analysis (taste, color, aroma and texture) and hedonic. The results showed that the size of coconut dregs and the ratio of coconut dregs: peanuts did not affect the water content, b*, aroma, but did affect the fiber content, L*, a*, browning index, sensory taste, color, texture and hedonic. The 25:75 g ratio of coarse coconut dreg to peanuts had the highest preference score, with water and fiber contents of 4.51% and 17.52 %, respectively. The browning index of the snack bar with the highest preference score was the lowest. The coarse coconut dreg had a browning index of 28.80. The browning index of the snack bar with a coconut dreg:peanut ratio of 25:75 g had a browning index of 27.61.
INNOVATION IN FERMENTED FUNCTIONAL BEVERAGES BASED ON NUTMEG SEEDS (Myristica Fragrans Houtt.) AND ACACIA HONEY AS A SOURCE OF NATURAL ANTIOXIDANTS: INOVASI DALAM MINUMAN FUNGSIONAL FERMENTASI BERBASIS BIJI PALA (Myristica Fragrans Houtt.) DAN MADU AKASIA SEBAGAI SUMBER ANTIOKSIDAN ALAMI Dodi Iskandar
ROCE : Jurnal Pertanian Terapan Vol. 3 No. 1 (2026): JPT ROCE 5, 2026
Publisher : PT. ROCE WISDOM ACEH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71275/roce.v3i1.162

Abstract

Nutmeg seeds (Myristica fragrans Houtt.) are rich in bioactive compounds and have strong potential for development as functional beverages. This study evaluated the effects of formulation ratio and fermentation duration on the physicochemical characteristics and antioxidant activity of a fermented nutmeg seed beverage supplemented with acacia honey. Three formulations with different nutmeg seed–acacia honey ratios were subjected to anaerobic fermentation for 15 and 30 days, followed by analysis of moisture content, sugar content, total acidity, insoluble solids, ash content, and antioxidant activity using the DPPH method (IC₅₀), with data evaluated by analysis of variance (ANOVA). The results showed that fermentation duration significantly affected moisture content, total acidity, ash content, and antioxidant activity (p < 0.05), while formulation ratio significantly influenced insoluble solid content and antioxidant performance. Moisture content ranged from 0.27% to 0.91%, sugar content from 0.64% to 0.75%, total acidity from 165.26 to 179.21, insoluble solids from 1.46% to 5.63%, and ash content from 0.17% to 0.93%. Antioxidant activity showed IC₅₀ values ranging from 56.85 to 148.59 μg/mL, with the highest activity observed in the formulation containing equal proportions of nutmeg seeds and acacia honey fermented for 30 days. These findings indicate that fermented nutmeg–acacia honey beverages possess promising functional properties, with formulation composition and fermentation time playing critical roles in optimizing antioxidant activity
ANTI-BREAST CANCER POTENTIAL AND WATER SOLUBILITY OF ETHYL ACETATE LEAF EXTRACT TEA FROM Uncaria gambir Roxb: POTENSI ANTI-KANKER PAYUDARA DAN KELARUTAN AIR DARI EKSTRAK DAUN TEH ETIL ASETAT DARI Uncaria gambir Roxb Virnalizi Dwimaharany; Dodi Iskandar; Desdy Hendra Gunawan
ROCE : Jurnal Pertanian Terapan Vol. 3 No. 2 (2026): JPT ROCE 6, 2026
Publisher : PT. ROCE WISDOM ACEH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71275/roce.v3i2.182

Abstract

The leaf extract of Uncaria gambir (UGR) was evaluated for its anticancer potential against 4T1 cells in vitro. Variations in soaking duration and mesh size affected extract yield, with 72-hour soaking and a mesh size of 60 producing the highest yield (32.6%). Polyphenolic compounds, particularly catechins, were identified as the main bioactive components, exhibiting dose-dependent cytotoxic effects, including induction of apoptosis, inhibition of cell proliferation, and modulation of oxidative stress. The IC₅₀ value of the UGR leaf water extract in this study was 1006.2 µg/mL, higher than previous reports (87.7 µg/mL), likely due to differences in extraction methods, solvent type, and analytical protocols. Water solubility data are relevant to pharmaceutical characterization, given the solubility and bioavailability challenges of catechins. These findings suggest that optimizing extraction methods or using catechin-rich fractions can enhance the anticancer potential of UGR. The study supports the potential of UGR as a breast cancer chemopreventive agent, highlighting the importance of appropriate extraction techniques to maximize bioactive compound content.
INFLUENCE OF SOAKING DURATION AND PARTICLE SIZE ON ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL CHARACTERISTICS OF Uncaria Gambir Roxb ETHANOLIC LEAF EXTRACT TEA: PENGARUH DURASI PERENDAMAN DAN UKURAN PARTIKEL TERHADAP AKTIVITAS ANTIOKSIDAN DAN KARAKTERISTIK FITOKIMIA TEH EKSTRAK DAUN Uncaria  Gambir Roxb DALAM ETANOL Dodi Iskandar; D.U.M Susilo; Erning Indrastuti; Rendy Fikrian Akmal
ROCE : Jurnal Pertanian Terapan Vol. 3 No. 2 (2026): JPT ROCE 6, 2026
Publisher : PT. ROCE WISDOM ACEH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71275/roce.v3i2.183

Abstract

Environmental pollution and modern lifestyles increase human exposure to free radicals, which contribute to various degenerative diseases. Antioxidants play a crucial role in neutralizing free radicals and preventing oxidative damage. Uncaria gambir Roxb., a tropical plant widely used in Indonesia, is rich in polyphenolic compounds, particularly catechins, with strong antioxidant potential. This study aimed to evaluate the antioxidant activity of ethanolic extracts of Uncaria gambir leaves through an integrated approach involving in silico prediction, extraction optimization, phytochemical screening, and in vitro antioxidant testing. Bioactive compounds were first screened using PASS Online to predict antioxidant and free radical scavenging activities. Ethanolic maceration was conducted using different particle sizes and maceration times, followed by yield determination. Phytochemical screening was performed to identify major secondary metabolites, and antioxidant activity was assessed using the DPPH radical-scavenging assay. In silico analysis indicated that most polyphenolic compounds exhibited high antioxidant potential. The highest extraction yield was obtained using a 60-mesh particle size and a 6-hour maceration period. Phytochemical screening confirmed a strong presence of phenolic compounds, and the DPPH assay showed a dose-dependent antioxidant response with a low IC₅₀ value, indicating strong antioxidant activity. These findings demonstrate that optimized ethanolic extracts of Uncaria gambir leaves have significant potential as natural antioxidant sources.
IN SILICO ANALYSIS OF BIOACTIVITY POTENTIAL AND PHARMACOKINETIC CHARACTERISTICS OF GRASS JELLY (Cyclea barbata) SECONDARY METABOLITES USING PASS ONLINE AND SWISSADME: ANALISIS IN SILICO POTENSI BIOAKTIVITAS DAN KARAKTERISTIK FARMAKOKINETIK METABOLIT SEKUNDER CINCAU HIJAU (Cyclea barbata) MENGGUNAKAN PASS ONLINE DAN SWISSADME Dimas Tama Suryadinata; Oktaviola Dea; Wildan Yudistira; Rofi Sufyan Zaki; Ana Maria Susana; Abdurrohman Rosyid; Ebenezer; Dodi Iskandar
ROCE : Jurnal Pertanian Terapan Vol. 3 No. 2 (2026): JPT ROCE 6, 2026
Publisher : PT. ROCE WISDOM ACEH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71275/roce.v3i2.205

Abstract

Green grass jelly (Cyclea barbata Miers) is a medicinal plant that contains various secondary metabolites with potential as sources of phytopharmaceutical candidates. This study aimed to analyze the bioactivity potential, drug-likeness characteristics, pharmacokinetic profile, medicinal chemistry properties, and toxicity of secondary metabolites present in Cyclea barbata using an in silico approach. The identified compounds were analyzed using PASS Online for biological activity prediction, SwissADME for drug-likeness and pharmacokinetic evaluation, and pkCSM for ADME/T (Absorption, Distribution, Metabolism, Excretion, and Toxicity) prediction. The results showed that tyramine and dopamine exhibited the highest biological activity as serotonin-release stimulants and MAP kinase pathway activators. Coclaurine, norcoclaurine, and N-methylcoclaurine demonstrated favorable drug-likeness profiles by satisfying most of the Lipinski, Veber, and Egan criteria. Pharmacokinetic analysis indicated that most simple compounds possessed high gastrointestinal absorption, whereas complex alkaloids such as tetrandrine and fangchinoline exhibited broader tissue distribution potential and greater blood–brain barrier permeability. Medicinal chemistry evaluation revealed that all compounds were free from PAINS alerts, while toxicity prediction indicated relatively favorable safety profiles for most compounds. The findings suggest that Cyclea barbata has considerable potential as a source of bioactive compounds for the development of modern phytopharmaceuticals, particularly as neuroprotective and anti-inflammatory agents. However, further validation through in vitro and in vivo studies is required to confirm the efficacy and safety of the predicted compounds.
IN SILICO ANALYSIS OF ANTIFUNGAL POTENTIAL, PHYSICOCHEMICAL PROPERTIES, DRUG-LIKENESS, AND TOXICITY OF BIOACTIVE COMPOUNDS OF Cannabis spp. AS BIOFUNGICIDE CANDIDATES FOR CONTROLLING FUNGAL DISEASES IN OIL PALM PLANTS: ANALISIS IN SILICO POTENSI ANTIFUNGI, SIFAT FISIKOKIMIA, DRUG-LIKENESS, DAN TOKSISITAS SENYAWA BIOAKTIF Cannabis spp. SEBAGAI KANDIDAT BIOFUNGISIDA UNTUK PENGENDALIAN PENYAKIT JAMUR PADA TANAMAN KELAPA SAWIT Okduartus Ryan; Muhammad Pirmansyah; Togu Pasternar Manik; seto kuncoro jati; Glenn Augusthio; uswatun nurul khoiriah; dodi iskandar
ROCE : Jurnal Pertanian Terapan Vol. 3 No. 2 (2026): JPT ROCE 6, 2026
Publisher : PT. ROCE WISDOM ACEH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71275/roce.v3i2.209

Abstract

This study aimed to evaluate the antifungal potential, physicochemical properties, drug-likeness characteristics, and toxicity profiles of bioactive compounds from Cannabis plants using in silico approaches. The analyses were conducted using PASS Online, SwissADME, and PKCSM platforms to identify potential natural antifungal agents for controlling fungal diseases in oil palm plants. PASS analysis demonstrated that several compounds exhibited strong antifungal activity, particularly glycoside flavonoids and cannabinoid compounds. Flavosativaside, orientin 7-glucoside, and flavocannabiside showed the highest Probability of Active (Pa) values, indicating promising antifungal potential. Cannabinoid compounds such as cannabidiol (CBD), cannabigerolic acid (CBGA), and tetrahydrocannabivarin also displayed considerable antifungal activity due to their lipophilic properties, which facilitate penetration into fungal cell membranes. SwissADME analysis revealed that most compounds possessed favorable physicochemical and pharmacokinetic characteristics, including acceptable lipophilicity, water solubility, and bioavailability. Several flavonoids and cannabinoids fulfilled major drug-likeness criteria, including Lipinski, Ghose, Veber, Egan, and Muegge rules, suggesting good potential for biological interaction and absorption. Simple flavonoids and cannabinoids exhibited more balanced polarity and membrane permeability than glycoside flavonoids, which generally had higher molecular weights and polar surface areas. PKCSM toxicity prediction indicated that most compounds were non-mutagenic and non-hepatotoxic, although several showed potential mutagenic or hepatotoxic effects that warrant further investigation. Environmental toxicity analysis suggested that most compounds exhibited low to moderate ecological toxicity, supporting their potential application as environmentally friendly biofungicides. Overall, the results indicate that Cannabis-derived compounds possess significant potential as natural antifungal agents for controlling fungal diseases in oil palm plantations. The integration of PASS, SwissADME, and PKCSM analyses provides an efficient preliminary screening strategy to identify effective and safe bioactive compounds before further in vitro and in vivo studies.
IN SILICO ANALYSIS OF ANTIFUNGAL POTENTIAL OF Centella asiatica ACTIVE COMPOUNDS AS NATURAL BIOFUNGICIDES FOR OIL PALM FUNGAL DISEASE CONTROL: ANALISIS IN SILICO POTENSI ANTIFUNGI SENYAWA AKTIF Centella asiatica SEBAGAI BIOFUNGISIDA ALAMI UNTUK PENGENDALIAN PENYAKIT JAMUR PADA TANAMAN KELAPA  SAWIT Danie Indra Yama; Muhammad Fiqri Marwanto; Adinda Aurelia Putri; Delia Ramadani; I Komang Wahyu Pradita; Muhammad Hidayat; Deko; Bahij Islami Pasha; Dodi Iskandar
ROCE : Jurnal Pertanian Terapan Vol. 3 No. 2 (2026): JPT ROCE 6, 2026
Publisher : PT. ROCE WISDOM ACEH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71275/roce.v3i2.212

Abstract

This study aimed to analyze the potential of active compounds in pegagan (Centella asiatica) as natural antifungal agents using an in silico approach with PASS Online, SwissADME, and pkCSM. The PASS Online analysis showed that most active compounds of pegagan had antifungal activity probability (Pa) values above 0.5, indicating relatively high biological potential. The compounds with the highest activity were 3-O-beta-D-Glucopyranosyl sitosterol (0.722), Centellin (0.715), Centellicin (0.655), Asiatic acid (0.651), and Kaempferol (0.651). Triterpenoid, flavonoid, and sesquiterpene compounds are known to act through mechanisms including disruption of the fungal cell membrane, inhibition of cell wall synthesis, interference with energy metabolism, and enhancement of oxidative stress in pathogenic cells. SwissADME analysis indicated that the majority of compounds exhibited good solubility, moderate lipophilicity, and bioavailability scores consistent with biological activity. Acetylursolic acid showed the highest bioavailability score of 0.85, while most other compounds ranged between 0.55 and 0.56. The drug-likeness results demonstrated that most compounds complied with Lipinski, Veber, and Muegge rules, indicating their potential as bioactive antifungal candidates. Physicochemical property analysis revealed TPSA values, hydrogen-bond donors and acceptors, and molecular flexibility that support membrane penetration and interactions with fungal biological targets. In addition, pkCSM results showed that most compounds were non-mutagenic, non-hepatotoxic, and exhibited relatively low environmental toxicity. Overall, the results suggest that pegagan has strong potential as a source of environmentally friendly natural antifungal compounds and may be further developed as a biofungicide for controlling fungal diseases in oil palm plants.
Co-Authors Abdurrohman Rosyid Adinda Aurelia Putri Ana Maria Susana Bahij Islami Pasha D.U.M Susilo Danie Indra Yama Deko Delia Ramadani Desdy Hendra Gunawan Dimas Tama Suryadinata Donor Utomo Muhammad Susilo Ebenezer Glenn Augusthio I Komang Wahyu Pradita Muhammad Fiqri Marwanto Muhammad Hidayat Muhammad Pirmansyah Okduartus Ryan Oktaviola Dea Rendy Fikrian Akmal Rofi Sufyan Zaki seto kuncoro jati Siti Aisyah Suharyani Amperawati Togu Pasternar Manik uswatun nurul khoiriah Virnalizi Dwimaharany Wildan Yudistira Y. Erning Indrastuti