<![CDATA[Streptococcus agalactiae is a pathogenic bacteria in aquaculture, causing streptococcosis in fish and causing significant economic losses. The pathogenicity of this bacteria is related to its virulence factors, including its ability to form biofilms that increase antibiotic resistance and host immune responses. One alternative approach to controlling infection is to disrupt the bacterial quorum sensing (QS) communication system through a quorum quenching mechanism. This study aims to analyze the potential of octopus ink extract as a quorum quenching agent in inhibiting S. agalactiae biofilm formation in aquaculture. The method used was a systematic literature review by collecting and analyzing various scientific sources such as journals, books, and relevant articles. Data analysis was carried out using content analysis techniques by selecting the literature most relevant to the research topic. The results of the study indicate that octopus ink contains bioactive compounds, especially alkaloids, which have the potential to inhibit the QS system, suppress the expression of virulence factors, and inhibit bacterial biofilm formation. In addition, octopus ink extract also has the potential to improve the immune system of farmed fish. Thus, octopus ink extract has the potential to be developed as an environmentally friendly antibiofilm and immunostimulant agent. Further research is needed to identify specific active compounds and test their effectiveness and safety on a cultivation scale.]]>
