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All Journal Indonesian Journal of Jamu
Rizka Fatriani
Tropical Biopharmaca Research Center, IPB University, Bogor, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Molecular Docking Study of Bioactive Compounds from Curcuma aeruginosa Roxb. as Antioxidant and Anticancer Activities Laksmi Ambarsari; Siti Nurjanah; I Made Artika; Rizka Fatriani
Jurnal Jamu Indonesia Vol. 8 No. 2 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i2.327

Abstract

Cancer is one type of dangerous disease that is increasing every year. Free radicals are the cause of gene mutations (cancer). Cancer will develop uncontrollably due to the occurrence of the cell cycle and the presence of compounds that trigger cell proliferation and inhibit the process of apoptosis. This cancer treatment is carried out by giving cyclin-dependent kinase2 (CDK2) and cyclooxygenase-2 (COX-2) inhibitor drugs to inhibit cancer development, as well as lipoxygenase (LOX) inhibitor drugs for the formation of free radicals. Curcuma aeruginosa RoxB., the plant, is known to have the potential for antioxidant and anticancer properties. This study aims to determine the molecular interaction between the dominant compound in the ethanol extract of C. aeruginosa with CDK2, COX-2, and LOX receptors. The type of ligand interaction with the receptor was determined through the parameters of affinity energy (∆G), inhibition constant (Ki), type of interaction, and percentage of binding site similarity (%BSS). The results showed that the gajutsulacton A had the best potential in inhibiting CDK2. The cucumenol may be a COX-2 inhibitor, and there are no compounds that can inhibit LOX as well as an antioxidant. Thus, our findings demonstrate the potential for C. aeruginosa bioactive to serve as anticancer candidate molecules against CDK2 and COX-2 receptors.
Phytochemical Screening, Cytotoxicity Test, and Antibacterial Activity Test of Wungu Plant Extract (Graptophyllum pictum L. Griff) Rini Anggi Arista; Mohammed A. Jalloh; Fahma Alifia Insani; Putri Azzahara Balqis; Cindy Larasati; Barieq Farial Putra Arief; Rizka Fatriani
Jurnal Jamu Indonesia Vol. 8 No. 2 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i2.330

Abstract

Indonesia boasts a rich array of medicinal herbs, including the wungu (Graptophyllum pictum L. Griff), which is known for its potential as an anticancer and antibacterial agent. Here, we used qualitative phytochemical assays to identify bioactive compounds in various parts of the wungu plant (leaves, stem, and roots) and their efficacy in combating cancer and bacterial infections. The brine shrimp lethality test (BSLT) was used to measure anticancer properties and antibacterial activity against Escherichia coli. We found that the leaves contained flavonoids, triterpenoids, phenols, saponins, and alkaloids, whereas the stem and root contained steroids and alkaloids. Notably, the wungu plant exhibited no toxicity, as shown by the cytotoxicity test, indicating a lack of anticancer potential as all parts showed LC50 values exceeding 1000 ppm. However, the antibacterial assays strikingly showed efficacy against bacteria across all parts of the plants, with varying strengths from weak to strong. This study sheds light on the promising antibacterial properties of the wungu plant and its potential as a therapeutic agent.
Co-Authors Barieq Farial Putra Arief Cindy Larasati Fahma Alifia Insani I MADE ARTIKA LAKSMI AMBARSARI Mohammed A. Jalloh Putri Azzahara Balqis Rini Anggi Arista Siti Nurjanah