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All Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Insan Farmasi Indonesia Indonesian Journal of Global Health Research
Vitarani Dwi Ananda Ningrum
Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Efektivitas Terapi dan Kejadian Tidak Dikehendaki Penggunaan Regimen Pengobatan Jangka Pendek pada MultiDrug-Resistant Tuberculosis: a Scoping Review Yunilistianingsih - Yunilistianingsih; Vitarani Dwi Ananda Ningrum
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.1970

Abstract

The increase in Multidrug-resistant Tuberculosis (MDR-TB) is a global problem that must be addressed immediately. Duration of treatment, adverse events (ADRs) and medical costs can affect adherence and treatment success. This literature review was conducted to review the effectiveness and ADRs of short-term regimens (STR) in MDR-TB patients. We used PubMed, ScienceDirect, and Google Scholar to retrieve the relevant original articles on MDR-TB treatment with STR in English-language, published from 2018 through 2022. The keywords used in the search for articles are "multi-drug-resistant tuberculosis", "short regimens" or "short-term regimens", effectiveness, safety" or "adverse events". Of the 13 articles obtained, the all-oral regimen proved promising for implementation in the treatment of MDR-TB. Based on sputum conversion, cure rate, and percentage of patients who completed treatment, the regimen with the highest therapeutic effectiveness was 6KmMfxPtoCfzHEZ/5MfxCfzEZ at 92.9%, and the lowest was 4KmMfxPtoCfzHEZ/5MfxCfzEZ at 63.6%. The all-oral regimen with or without Bedaquilin showed a better average therapeutic effectiveness (87.04%) than regimen containing injection (78.43%). Meanwhile, the serious ADRs that emerged were death, cardiotoxicity, hepatotoxicity and ototoxicity. Apart from monitoring the safety, research needs to be expanded to a larger population and wider sites, to find more effective regimens because Mycobacterium tuberculosis are easily resistant.
TINJAUAN NARATIF EFEKTIVITAS DAN KEAMANAN ANTIRETROVIRAL PADA PASIEN DENGAN KOINFEKSI HIV-HBV Rizky Yuliatus Solicha; Vitarani Dwi Ananda Ningrum
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v9i1.3029

Abstract

HIV-HBV coinfection remains a major global health challenge associated with increased morbidity and mortality. Various studies have evaluated the effectiveness and safety of antiviral therapies in coinfected patients; however, the findings remain inconsistent. This narrative review aimed to summarize the current evidence regarding the effectiveness and safety of antiretroviral therapy in patients with HIV-HBV coinfection. Literature searches were conducted through PubMed and Google Scholar for studies published between 2014 and 2025 using keywords related to HIV, hepatitis B, nucleos(t)ide analogues, interferon alfa, effectiveness, and safety. The findings demonstrated that the TLD regimen (tenofovir, lamivudine, and dolutegravir) showed superior virological outcomes compared with TLE (tenofovir, lamivudine, and efavirenz), including higher viral suppression rates and greater CD4 cell recovery. Nucleos(t)ide analogues such as entecavir and telbivudine effectively reduced HBV DNA levels and improved liver function markers. However, several adverse drug reactions were reported, including dizziness, nausea, vomiting, metabolic disturbances, and renal impairment, particularly with tenofovir-containing regimens. Interferon alfa also demonstrated potential benefits in enhancing seroconversion. Overall, TLD is considered the preferred regimen due to its superior efficacy and resistance profile, although careful monitoring for adverse effects remains essential.
Integrating Drug-Related Problems Identification and INA-CBGs Cost Gap Analysis in Hemorrhagic Stroke Patients with Hypertension: A PCNE-Based Systematic Review Deddy Setyagus Ariawan; Dhanang Prawira Nugraha; Fithria Dyah Ayu; Vitarani Dwi Ananda Ningrum; Julaeha Julaeha
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.151

Abstract

Hemorrhagic stroke with comorbid hypertension is a complex clinical condition with a high economic burden. In the National Health Insurance (JKN) financing system, INA-CBG package rates often do not reflect the actual costs incurred by hospitals. One potential factor contributing to this cost gap is Drug-Related Problems (DRPs), which include incorrect dosing, drug interactions, and inappropriate therapy.Objective to assess the impact of DRPs on the cost gap between INA-CBG tariffs and actual costs of hemorrhagic stroke care with hypertension, as well as to evaluate the effectiveness of the PCNE method in identifying DRPs. Following PRISMA guidelines, a literature search was conducted on PubMed, ScienceDirect, ProQuest, and Google Scholar (2020–2025) using keywords related to hemorrhagic stroke, hypertension, cost-effectiveness, INA-CBGs, and PCNE. Primary studies analyzing DRPs and/or comparing actual costs with INA-CBGs tariffs in hemorrhagic stroke patients were included. The data were synthesized narratively, focusing on types of DRPs, application of PCNE, and cost gaps. Of 195 articles, 11 were included in the synthesis, with 3 highly relevant. DRPs (eg, inappropriate drug selection) were detected in over 60% of cases using PCNE, leading to increased costs. The gap between actual costs and INA-CBGs tariffs reached up to IDR 8 million. DRPs are significant determinants of cost inefficiency in the care of hemorrhagic stroke patients with hypertension. Systematic implementation of the PCNE method integrated with pharmacoeconomic evaluation is recommended to support the sustainability of JKN. This study suggests tariff adjustments for INA-CBGs and an expanded role for pharmacists.
Tingkat Pengetahuan dan Kepedulian Masyarakat tentang Keamanan Penggunaan Kosmetik: Scoping Review Rahma Sakti Oktavia Rahma; Vitarani Dwi Ananda Ningrum; Okti Ratna Mafruhah
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 22 No. 02 Desember 2025
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v22i2.27015

Abstract

Kosmetovigilans adalah praktik penting untuk menjamin keamanan penggunaan kosmetik di masyarakat. Di Indonesia, peran ini diemban oleh lembaga seperti BPOM, tetapi efektivitasnya bergantung pada pengetahuan, perspektif, dan sikap masyarakat dalam melaporkan efek samping serta memilih produk yang aman. Scoping review ini bertujuan menganalisis tingkat pengetahuan masyarakat tentang kosmetovigilans dan mengidentifikasi kesenjangan pengetahuan dan faktor-faktor yang memengaruhi kesadaran masyarakat terhadap kosmetovigilans. Scoping review dilakukan dengan pencarian literatur dari PubMed, Science Direct, dan Google Scholar menggunakan kata kunci knowledge of cosmetovigilance, awareness of cosmetic safety, public understanding cosmetovigilance, Factors Influencing Public Awareness of Cosmetovigilance. Artikel yang dipilih adalah studi yang membahas pengetahuan atau kesadaran masyarakat tentang kosmetovigilans, studi dalam bahasa Inggris atau Indonesia, dan studi yang diterbitkan dalam 5 tahun terakhir. Review ini menunjukkan kesenjangan antara kesadaran dan tindakan konsumen terkait keamanan kosmetik di berbagai wilayah. Di India, sebanyak 95,11% responden menyadari efek samping kosmetik, namun hanya 68,43% memahami konsep ‘keamanan kosmetik’. Sementara itu, di Arab Saudi, 74% responden menggunakan tabir surya, tetapi hanya 16% yang melakukannya secara rutin. Selain itu, 16,1% wanita melaporkan efek samping kosmetik. Di Sri Lanka, banyak mahasiswa mengalami jerawat dan alergi akibat kosmetik yang tidak sesuai. Adapun di Portugal, sebanyak 93% konsumen tidak mengetahui kadar THC yang aman pada produk kosmetik berbasis cannabis. Data ini menunjukkan perlunya edukasi dan regulasi yang lebih baik di berbagai wilayah. Meskipun kosmetik bermanfaat, banyak konsumen kurang sadar akan resikonya. Edukasi, regulasi yang ketat, dan sistem pelaporan yang baik dibutuhkan untuk melindungi konsumen. Kolaborasi pemerintah, industri, dan masyarakat menjamin kosmetik berkualitas.
Co-Authors Deddy Setyagus Ariawan Dhanang Prawira Nugraha Fithria Dyah Ayu Julaeha Julaeha Okti Ratna Mafruhah Rahma Sakti Oktavia Rahma Rizky Yuliatus Solicha Yunilistianingsih - Yunilistianingsih