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Johana Puspasari Dwi Pratiwi
Universitas Kristen Duta Wacana
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Senescence-Associated Secretory Phenotype as a Key Driver of Intestinal Aging: A Narrative Review Yustina Nuke Ardiyan; Johana Puspasari Dwi Pratiwi
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 2 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i2.557

Abstract

Population aging is accompanied by progressive deterioration of intestinal structure and function, leading to impaired epithelial regeneration, increased intestinal permeability, chronic inflammation, and gut microbiota dysbiosis. Emerging evidence has identified the senescence-associated secretory phenotype (SASP) as a major mediator linking cellular senescence to intestinal aging; however, current evidence remains fragmented. This narrative review aimed to synthesize recent findings regarding the role of SASP in intestinal aging, with particular emphasis on its molecular mechanisms, biological consequences, and potential therapeutic strategies. A literature search was conducted in PubMed using the keywords ("senescence-associated secretory phenotype" OR SASP) AND (gut OR intestin* OR gastrointestin*) AND aging. The initial search identified 113 publications. After title and abstract screening, 60 articles were retained, and the exclusion of review articles and other non-original publications resulted in 28 original studies. Following full-text assessment, 26 articles were included for qualitative synthesis. The available evidence indicates that SASP contributes to intestinal aging by promoting chronic inflammation, impairing intestinal stem cell function, disrupting epithelial barrier integrity, remodeling the extracellular matrix, and altering gut microbiota composition. These interconnected mechanisms create a self-amplifying cycle that accelerates intestinal dysfunction and the loss of tissue homeostasis. Furthermore, emerging senotherapeutic approaches, including senolytics, senomorphics, and microbiota-targeted interventions, show promise in mitigating SASP-mediated intestinal aging. Overall, SASP represents both a key mechanistic driver and a promising therapeutic target for preserving intestinal homeostasis and promoting healthy aging.
Biogenesis and Function of miRNAs and Their Role in Cancer Yustina Nuke Ardiyan; Johana Puspasari Dwi Pratiwi
Jurnal Impresi Indonesia Vol. 3 No. 6 (2024): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v3i6.4974

Abstract

MicroRNA (miRNA) is a small RNA molecule that regulates post-transcriptional gene expression. miRNA combines with the RNA-induced silencing complex (RISC) and carries out its function in controlling translation. The formation of miRNA involves enzymes and proteins that cut it in its processing as well as protein complexes in the cytoplasm that make the miRNA mature. Several changes, for example deletion or overexpression, can occur in miRNAs, causing cancer growth. The aim of this study was to investigate the process of miRNA biogenesis as well as analyze how changes in miRNA expression can affect the biological pathways involved in cancer. This type of research is a literature review. The data that has been collected is then analyzed in three stages, namely data reduction, data presentation and drawing conclusions. The results show that the role of miRNAs is in the post-transcriptional regulation of genes. MiRNAs associate with the RISC complex and interact with mRNA through complementary base pairing thereby halting translation and promoting mRNA degradation. MiRNAs are deregulated in cancer, including over-expression of oncogenic miRNAs or deletion of miRNA characteristics as tumor inhibitors. The results of this research also provide a foundation for further education and advanced research in the field of molecular biology, particularly in genetic regulation and disease mechanisms.
Co-Authors Ardiyan, Yustina Nuke