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Immature Platelets in Hematologic Malignancies: A Meta-Analysis Lailly, Mirna Fauziah; Ahmad, Thariq; Lestari, Essa Loyalita
INFLUENCE: INTERNATIONAL JOURNAL OF SCIENCE REVIEW Vol. 7 No. 1 (2025): INFLUENCE: International Journal of Science Review
Publisher : Global Writing Academica Researching and Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/influencejournal.v7i1.272

Abstract

Thrombocytopenia is a common hematological complication in patients with malignant hematological diseases, particularly after chemotherapy or hematopoietic stem cell transplantation (HSCT). This condition increases the risk of bleeding and necessitates strict hematological monitoring and platelet transfusions. Immature Platelet Fraction (IPF), a parameter reflecting thrombopoiesis, has emerged as a potential biomarker for predicting platelet recovery. This meta-analysis evaluates the role of IPF and IPF% in predicting platelet recovery in patients with hematological malignancies post-chemotherapy and HSCT. A systematic literature search was conducted across multiple databases, including PubMed, EMBASE, and Cochrane Library, from 2014 to 2024. Studies were selected based on predefined criteria, including patient population, intervention, and outcomes related to platelet recovery. The analysis revealed that IPF% increases earlier than other hematological parameters, with a peak occurring 1–11 days before platelet recovery. However, significant heterogeneity (I² = 99%) was observed among studies, indicating variability in methodologies and patient populations. Despite promising results, the clinical application of IPF% requires further validation to establish optimal cutoff values and standardize measurement techniques. This meta-analysis highlights the potential of IPF% as a predictive biomarker for platelet recovery, while emphasizing the need for more robust studies to enhance its reliability in clinical practice.
MODEL OF THE INFLUENCE OF QUALITY OF WORK LIFE (QWL) ON EMPLOYEE PERFORMANCE THROUGH ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) AT AMAL SEHAT HOSPITAL SRAGEN, CENTRAL JAVA, 2024 Lailly, Mirna Fauziah; Jayanagara, Oscar
Jurnal Ilmiah Manajemen, Ekonomi, & Akuntansi (MEA) Vol 8 No 2 (2024): Edisi Mei - Agustus 2024
Publisher : LPPM STIE Muhammadiah Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31955/mea.v8i2.4409

Abstract

This research aims to explore the effect of Quality of Work Life (QWL) on employee performance, with Organizational Citizenship Behavior (OCB) acting as a mediator, at Amal Sehat Sragen Hospital in Central Java in 2024. Employing a quantitative research approach, data was gathered through a non-probability sampling method, specifically purposive sampling. Surveys were administered to and completed by 77 hospital employees. The collected data was examined using Partial Least Squares Structural Equation Modeling (PLS-SEM). The results show that Organizational Citizenship Behavior significantly impacts Employee Performance. Additionally, Quality of Work Life positively affects Organizational Citizenship Behavior and directly influences Employee Performance. The study also demonstrates that Quality of Work Life indirectly boosts Employee Performance by positively affecting Organizational Citizenship Behavior. This research provides valuable insights into the mechanisms through which QWL can foster desirable workplace behaviors and ultimately enhance employee performance in healthcare settings like Amal Sehat Sragen Hospital.