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All Journal Pharmacy Reports TeknoKreatif: Jurnal Pengabdian kepada Masyarakat
Purwanata, I Gede Raditya
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Other

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Sosialisasi Pembuatan Teh Celup Bunga Rosella (Hibiscus sabdariffa L.) dan Seledri (Apium graveolens L.) Sebagai Pengontrol Tekanan Darah di Dusun Serbajadi Purwanata, I Gede Raditya
TeknoKreatif: Jurnal Pengabdian kepada Masyarakat Vol 4 No 1 (2024): TEKNOKREATIF : Jurnal Pengabdian kepada Masyarakat Volume 4 No 1
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M), Institut Teknologi Sumatera, Lampung, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/teknokreatif.v4i1.1676

Abstract

Penelitian ini mengkaji pemanfaatan tanaman seledri dan rosella sebagai obat tradisional untuk mengontrol hipertensi di Dusun Serbajadi, Lampung Selatan. Sosialisasi dan demonstrasi dilakukan bersama ibu-ibu PKK dengan metode tatap muka. Hasil pretest dan posttest menunjukkan peningkatan pemahaman peserta, dengan rata-rata nilai meningkat dari 64,41 menjadi 95,88. Demonstrasi pembuatan teh celup rosella dan seledri memberikan gambaran praktis penggunaan tanaman herbal. Evaluasi ini menjadi titik awal untuk melihat minat dan antusiasme masyarakat terhadap tanaman herbal sebagai pengontrol tekanan darah. Studi ini diharapkan dapat mendorong adopsi tanaman herbal sebagai bagian dari gaya hidup sehat masyarakat. Kata kunci: seledri, rosella, tanaman herbal, teh celup
Potential of cocoa (Theobroma cacao) shell for diabetic neuropathy targeting transient receptor potential canonical (TRPC): an in silico study Pangestu, Maryo Adjie; Sarmoko; Purwanata, I Gede Raditya; Zusela, Titah
Pharmacy Reports Vol. 2 No. 3 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.80

Abstract

Diabetic neuropathy, a painful complication of diabetes mellitus, may potentially be treated with compounds found in cocoa pods. This study investigates the interactions of various flavonoids (catechin, epicatechin, quercetin, luteolin, apigenin, naringenin, and procyanidin) contained in the cocoa pod to the Canonical Transient Receptor Potential (TRPC6) receptor. Molecular docking, facilitated by Autodock software, was employed to predict the binding affinities of these compounds to TRPC6. This involved preparing the molecular structures of the flavonoids and the TRPC6 protein for simulation. The simulation provided insights into the binding efficiencies and interaction energies between the flavonoids and TRPC6. The findings indicate that procyanidin and quercetin exhibit the highest binding energies, at -7.15 kcal/mol and -6.37 kcal/mol, respectively. Procyanidin interacts with the amino acid residues Ala508, Arg609, Arg758, Asn765, Asp530, Glu512, His446, and Met505, while quercetin binds to Arg758, Asp530, Glu512, and Glu524. These results highlight the potential of quercetin and procyanidin as candidates for the development of TRPC6-targeted treatments for diabetic neuropathy. This study lays the groundwork for the creation of new, effective, and safe diabetic neuropathy medications.
Clinical efficacy of guava (Psidium guajava L.) in human trials: A review of therapeutic and nutritional applications Ni Pande Made Ayu Dinda Saraswati, Dinda; Purwanata, I Gede Raditya
Pharmacy Reports Vol. 3 No. 3 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.85

Abstract

This review examines clinical evidence for guava's therapeutic efficacy across multiple health domains. Randomized controlled trials reveal guava's significant impacts on metabolic health, demonstrating reduced postprandial glucose responses, improved lipid profiles, and decreased blood pressure. Nutritional intervention studies establish guava as an effective food-based strategy for improving iron status in vulnerable populations through enhanced iron absorption, particularly in children and pregnant women. Additional clinical evidence supports guava's applications in musculoskeletal health (reducing knee pain), dermatological care (controlling sebum production), oral health (preventing gingivitis and reducing oral pathogens), and gastrointestinal disorders (alleviating diarrheal symptoms). These diverse therapeutic effects stem from guava's rich phytochemical profile, including flavonoids, carotenoids, and exceptionally high vitamin C content. The review highlights guava's versatility as a well-tolerated, accessible intervention that aligns with sustainable, food-based approaches to health management. While current evidence provides a foundation for guava's clinical applications, future research should further elucidate mechanisms of action, optimize preparations, and explore additional therapeutic potential. Guava emerges as a scientifically validated therapeutic agent with significant potential to improve health outcomes across diverse populations and conditions.
Co-Authors Ni Pande Made Ayu Dinda Saraswati, Dinda Pangestu, Maryo Adjie Sarmoko Sarmoko Zusela, Titah