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All Journal Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh Media Dermato-Venereologica Indonesiana
Karamina Maghfirah
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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HERPES ZOSTER PADA PASIEN ARTRITIS REUMATOID YANG MENDAPAT TERAPI METOTREKSAT: SEBUAH LAPORAN KASUS Nanda Earlia; Vella Vella; Arie Hidayati; Aqil Yuniawan Tasrif; Mikyal Bulqiah; Aldilla Prasditha; Karamina Maghfirah
Media Dermato-Venereologica Indonesiana Vol 50 No 3 (2023): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i3.386

Abstract

Background: Herpes zoster (HZ) is an acute infection caused by varicella zoster (VZV) reactivation that manifests clinically as groupings of vesicles and eruptions on a reddish skin base, along with unilateral radicular pain that is often localized to one dermatome. Case Ilustration: A 50-year-old woman arrived complaining of uncomfortable wet bumps on her left back. The patient has received consistent care at the Internal Medicine Polyclinic for the past 7 years despite having a prior history of rheumatoid arthritis. In the left posterior thoracic area, there was evidence of a dermatological condition. Groups of vesicles filled with clear fluid were observed there, along with skin that was unilaterally distributed and erythematous, zoosteriform, and plaque-based. Diagnosed with herpes zoster in the patient. Acyclovir, gabapentin, and paracetamol were administered orally. Mupirocin 2% cream and a wet compress with NaCl solution were used as topical treatments. Rheumatoid arthritis (methotrexate and sulfasalazine) treatment was stopped during HZ treatment. Skin blemishes had improved after receiving treatment for two weeks. Conclusion: After a prior varicella assault, the latent endogenous varicella zoster virus (VZV) in ganglionic neurons reactivates to cause herpes zoster. Herpes zoster risk will grow in immune-compromised states.
Pengaruh Pemberian Platelet-Rich Plasma Terhadap Derajat Keparahan Psoriasis Vulgaris Nanda Earlia; Cut Yunita; Mikyal Bulqiah; Aqil Yuniawan Tasrif; Karamina Maghfirah
Journal of Medical Science Vol 3 No 2 (2022): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v3i2.79

Abstract

Psoriasis vulgaris is an autoimmune disease that is influenced by multifactor, namely environmental, genetic (HLA-Cw6), and immune system dysregulation (IL-17 or IL-22), resulting in increased proliferation of keratinosit in the epidermis. Histologically characterized by parakeratosis, hyperkeratosis, elongated rete ridge, Monro micro abscess, and Kogoj micro abscess. The clinical picture is red patches with thick scales, especially in the trauma area. Platelet Rich Plasma (PRP) is an autologous preparation of platelets that strengthens in plasma and is a powerful anti-inflammatory agent. The immunomodulatory and anti-inflammatory effects of PRP are believed to play a role in the treatment of chronic inflammation patients. One of the important mediators in the pathogenesis of psoriasis is nuclear factor kappa B (NF-κB) and PRP exerting an inhibitory effect on NF-κB. The aim of the study was to assess the effect of PRP on the severity and quality of life of psoriasis vulgaris patients. The design of this study is a paired numerical comparative analysis using two groups with two measurements. The research design was a randomized, undisguised clinical trial and a parallel design. The study lasted for 6 weeks. Sampling was done by total sampling involving 20 psoriasis Vulgaris patients, then divided into two groups: intervention group and control group. The test group received 2 PRP injections and topical combination therapy (salicylic acid 3% + Vaseline album cream), while the control group only received topical combination therapy. The results of this study found a decrease in PASI and DLQI scores in the intervention group compared to the control group (p<0.005). This study concludes that the administration of PRP can reduce the severity of psoriasis Vulgaris as well as improve the quality of life of psoriasis Vulgaris patients.
Co-Authors Aldilla Prasditha Aqil Yuniawan Tasrif Arie Hidayati Cut Yunita Mikyal Bulqiah Nanda Earlia Nanda Earlia Vella Vella