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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Biology, Medicine, & Natural Product Chemistry Media Dermato-Venereologica Indonesiana
Nanda Earlia
Department Of Dermatology And Venereology, Faculty Of Medicine, Universitas Syiah Kuala, Dr. Zainal Abidin General Academic Hospital, Banda Aceh, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Quercetin: the bioactive compound from Allium cepa L. as anti-inflammation based on in silico screening Mohamad Amin; Kurniawan Setia Putra; Ihya Fakhrurizal Amin; Nanda Earlia; Dina Maulina; Betty Lukiati; Umie Lestari
Biology, Medicine, & Natural Product Chemistry Vol 7, No 1 (2018)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.812 KB) | DOI: 10.14421/biomedich.2018.71.27-31

Abstract

Inflammation is a tissue injury that occurs due to physical trauma or microbiological substances that involve the activities of many cell types. Inflammation can be prevented using the natural medicines from Allium cepa L. Quercetin is one of the bioactive compounds found in Allium cepa L and has been reported to have anti-inflammatory activity. The natural medicines have been used to minimize non-steroidal anti-inflammatory drugs. This study aims to investigated the modeling structures and the protein receptor from quecertin in inflammation mechanism and their optimization of the effectiveness in the human body. The bioinformatics tools used in this study are the database of quercetin compounds, Pubchem and Swis Target Prediction protein prediction databases, PyRx 0.8 molecular docking software, ligand docking, and binding site analysis with PyMOL and LigPlus software. The results from in silico show that quercetin compounds can interact with Muscleblind-like protein 1 target protein with a Binding Affinity minus value which is not much different from the dexamethasone compound. Dexamethason is a standart because it is a corticosteroid drug that can be used as an anti-inflammatory to reduce inflammation, allergic reactions, arthritis and other inflammatory diseases.
The Profile of Leprosy Patients in Aceh: Retrospective Study Nanda Earlia; Sulamsih Sri Budini; Dea Silvia Ramadana; Mikyal Bulqiah; Aqil Yuliawan Tasrif; Randika Richard R; Muhammad Adji Pangestu; Annisa Raihani; Auni Batrisyia; Eva Cahyaningsih; Fanny Adlin Nurafika; Istiqomah Genepo; Nadira Sabrina Mufti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.46-51

Abstract

Backgrounds: Morbus Hansen or leprosy is a chronic granulomatous infectious disease caused by the obligate intracellular Mycobacterium leprae bacillus. Leprosy can cause loss of sensation in the skin with or without lesions and body dysfunction during the course of the disease. In Aceh, there were 337 new cases of leprosy in 2019 and this was the highest case in Sumatra. Purpose: To analyze the profile of leprosy patients in the Department of Dermatology and Venereology of RSUDZA Banda Aceh. Methods: Observational descriptive study with retrospective design, using medical record of leprosy patients who visited Dermatology and Venereology Outpatient Clinic RSUDZA Banda Aceh for the period of January 2017 – December 2021. Result: A total of 183 leprosy patients were obtained from the study. Most cases occured in male patients (68.3%), the majority was in the 18-40 year age group (60.1%), most patients live outside of Banda Aceh (71%). The most frequently reported type of leprosy was the multibacillary type (71.6%). Leprosy patients without disability were 35.5%, the majority did not experience a leprosy reaction (71%), the most common morphology of the lesion was erythematous (29.5%), and the highest proportion of the bacteriological and morphological index was negative (46.4% and 50.8% respectively). Conclusion: The diagnosis of leprosy was based on clinical, bacteriological, and histopathological features. Early diagnosis, patient access to treatment, early initiation of treatment and adherence to therapy would reduce the disease transmission thus would decrease the prevalence of leprosy in Aceh.
HERPES ZOSTER PADA PASIEN ARTRITIS REUMATOID YANG MENDAPAT TERAPI METOTREKSAT: SEBUAH LAPORAN KASUS Nanda Earlia; Vella Vella; Arie Hidayati; Aqil Yuniawan Tasrif; Mikyal Bulqiah; Aldilla Prasditha; Karamina Maghfirah
Media Dermato-Venereologica Indonesiana Vol 50 No 3 (2023): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i3.386

Abstract

Background: Herpes zoster (HZ) is an acute infection caused by varicella zoster (VZV) reactivation that manifests clinically as groupings of vesicles and eruptions on a reddish skin base, along with unilateral radicular pain that is often localized to one dermatome. Case Ilustration: A 50-year-old woman arrived complaining of uncomfortable wet bumps on her left back. The patient has received consistent care at the Internal Medicine Polyclinic for the past 7 years despite having a prior history of rheumatoid arthritis. In the left posterior thoracic area, there was evidence of a dermatological condition. Groups of vesicles filled with clear fluid were observed there, along with skin that was unilaterally distributed and erythematous, zoosteriform, and plaque-based. Diagnosed with herpes zoster in the patient. Acyclovir, gabapentin, and paracetamol were administered orally. Mupirocin 2% cream and a wet compress with NaCl solution were used as topical treatments. Rheumatoid arthritis (methotrexate and sulfasalazine) treatment was stopped during HZ treatment. Skin blemishes had improved after receiving treatment for two weeks. Conclusion: After a prior varicella assault, the latent endogenous varicella zoster virus (VZV) in ganglionic neurons reactivates to cause herpes zoster. Herpes zoster risk will grow in immune-compromised states.
Co-Authors Aldilla Prasditha Annisa Raihani Aqil Yuliawan Tasrif Aqil Yuniawan Tasrif Arie Hidayati Auni Batrisyia Betty Lukiati Dea Silvia Ramadana Dina Maulina Eva Cahyaningsih Fanny Adlin Nurafika Ihya Fakhrurizal Amin Istiqomah Genepo Karamina Maghfirah Kurniawan Setia Putra Mikyal Bulqiah Mikyal Bulqiah Mohamad Amin Muhammad Adji Pangestu Nadira Sabrina Mufti Randika Richard R Sulamsih Sri Budini Umie Lestari Vella Vella