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All Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Pase, M Aron
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Measurement of Visceral Adipose Tissue using Abdomen CT scan As A Predictor of Type 2 Diabetes Mellitus at H. Adam Malik General Hospital Medan Nasution, Duma Ratna Sari; Putri Chairani Eyanoer; Pase, M Aron; Lubis, Netty Delvrita
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 1 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i1.15891

Abstract

ABSTRACT Background: Obesity is a condition where the BMI is ≥ 25 kg/m2. Deposition of visceral adipose tissue (VAT) in obese conditions is a predictor of the incidence of type 2 diabetes mellitus. CT scan is an accurate measurement of VAT. A cut-off point value is needed to determine the stratification of VAT at risk for type 2 DM. Method: Cross-sectional study of patients undergoing CT scans of the abdominal area at the Radiology Installation of H. Adam Malik General Hospital, Medan during February 2024. Some of the data was taken from the Master of Clinical Medicine study in 2022. Data was collected in the form of examination BMI, waist circumference, DM risk score, and VAT volume in patients examined by abdominal CT scan at L4 level. The DM risk score was obtained using the ADA diabetes risk score questionnaire. VAT volume measurement using 3D segmentation tools. Results: Of the 116 patients studied, the number of samples was 53,4% male and 46,6% female. High DM risk score proportion of 59,5 %. The most frequent DM risk score was 5. Spearman’s correlation is used too. The best cut-off point between sensitivity 44.93% and specificity 80,85% is 1.311,9 cm3. The accuracy of CT scan as a predictor of type 2 DM is good (AUC 0.7). The positive predictive value (PPV) is 77,50%, and the negative predictive value (NPV) is 50%. The positive likelihood ratio value (LR +) is 2,34 and the negative likelihood ratio value (LR -) is 0,68. Conclusion: VAT measurement using abdominal CT scan as a predictor of type 2 DM has good accuracy. Keywords: Visceral adipose tissue, cut off, diabetes mellitus, body mass index, waist circumference, abdominal CT scan
The Association Between Lipid Profiles and Atherogenic Index with Diabetic Foot Severity According to the Wagner-Meggitt Classification at Adam Malik Hospital Wilonna, Almira; Pase, M Aron; Lubis, Dian Anindita
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 1 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i1.18383

Abstract

ABSTRACTIntroduction: Diabetic foot is a serious complication that leads to ulcers and amputations. Identifying risk factors, such as lipid profiles and atherogenic indices is crucial for prevention and treatment for cardiovascular disease and peripheral arterial disease. This study aims to investigate the relationship between lipid profiles and atherogenic indices with the severity of diabetic foot, categorized by the Wagner-Meggitt classification, at Adam Malik Hospital. Methods: This analytical observational study with cross-sectional design was conducted at Adam Malik Hospital, involving 70 diabetic foot patients. Data were collected from medical records, focusing on lipid profiles. Atherogenic indices were calculated as ratios: TC/HDL, TG/HDL, and LDL/HDL. The severity of diabetic foot was measured using the Wagner-Meggitt classification. Statistical analysis included Chi-square and Spearman's rho tests. Results: Of the 70 patients, most were aged 51-60 (41.4%), male (60%), and had normal BMI (57.1%). There was a significant correlation between diabetic foot severity and triglyceride levels (p=0.0002, r=0.358) as well as the TC/HDL ratio (p=0.02, r=-0.277). However, no significant relationships were found for total cholesterol (p=0.533), HDL (p=0.254), LDL (p=0.533), the TG/HDL ratio (p=0.158), or the LDL/HDL ratio (p=0.92). Discussion: In this study, 60% of the participants were male. The findings align with previous studies, demonstrating a correlation between elevated triglycerides and lipid profile abnormalities with the severity of diabetic foot ulcers. Conclusion: Triglycerides and the total cholesterol/HDL ratio are significantly associated with the severity of diabetic foot based on the Wagner-Meggitt classification.   Keywords: diabetic foot; lipid profile; atherogenic index; Wagner-Meggitt
ASSOCIATION BETWEEN HbA1c WITH PLATELET TO LYMPHOCYTE RATIO AND NEUTROPHIL TO LYMPHOCYTE RATIO IN TYPE 2 DIABETES MELLITUS Villarsi, Devinda; Brama Ihsan Sazli; Pase, M Aron
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 8 No. 1 (2026): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v8i1.23024

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease in which inflammation plays a significant role in both microvascular and macrovascular complications. The Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) are simple hematological biomarkers that can reflect systemic inflammatory status and potentially correlate with HbA1c levels as an indicator of glycemic control. Objective: To determine the association between HbA1c levels and NLR and PLR in T2DM patients at Haji Adam Malik General Hospital, Medan. Methods: This was a retrospective cross-sectional study using secondary data from the medical records of T2DM patients between May and July 2024. A total of 96 patients met the inclusion criteria. Data were analyzed using the Kruskal-Wallis test with a significance level of p<0.05. Results: The median HbA1c of the patients was 9% (range 4.2–15.4%). Median NLR increased according to HbA1c categories: 3.91 (HbA1c <7%), 5.77 (HbA1c 7–9%), and 7.19 (HbA1c >9%) with p=0.012. Median PLR also increased across categories: 134.75, 189.00, and 233.33 with p=0.009. Conclusion: A significant association was observed between HbA1c and both NLR (p = 0.012) and PLR (p = 0.009). NLR and PLR can be used as additional hematological parameters to assess inflammation and glycemic control in patients with type 2 diabetes.
Co-Authors Brama Ihsan Sazli Lubis, Dian Anindita Lubis, Netty Delvrita Nasution, Duma Ratna Sari Putri Chairani Eyanoer, Putri Chairani Villarsi, Devinda Wilonna, Almira