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All Journal Sumatera Medical Journal
Mani, Suresh
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Immunology & microbiology Medicine & Pharmacology

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Subacute Toxicity of Yellow Flower Extract (Cananga odorata) on the Histopathology of White Rat Heart (Rattus norvegicus) Mani, Suresh; Akbari Ganie, Ratna; Keumala Sari, Dina; Meutia Sari, Liza; Rachmawati, Meike; Muhammad, Noorzaid
Sumatera Medical Journal Vol. 6 No. 2 (2023): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v6i2.11931

Abstract

Background: The inflammatory process is influenced by chemical mediators such as Nitric Oxide (NO), cytokines, and arachidonic acid metabolites. The therapeutic effect of herbal plants comes from phytochemicals with strong antioxidant activity. Objective: To examine the phytochemical content and anti-inflammatory effects of Cananga odorata. Methods: This was a two-stage study: in vitro and in vivo. Anti-inflammatory activity is related not only to antioxidant properties but also to suppression of nitric oxide and pro-inflammatory cytokines. This effect is being explored using various herbal plants. One such plant is Cananga odorata (ylang flower), a tropical plant with fragrant petals that grows easily. Results: The total phenol content was 1.06% w/w. Antioxidant activity measured using DPPH method showed an IC50 of 808.86 ppm, indicating weak antioxidant activity. In rats, the extract reduced blood glucose levels but had no effect on lipid profiles. Toxicity testing showed no toxic effects. Histological analysis showed no differences between cardiovascular disease model mice and standard-fed mice. Conclusion: The ethanol extract of Cananga odorata did not show toxicity in the heart histopathology of white rats.
Clinical Efficacy of Repetitive Transcranial Magnetic Stimulation in Recovery of Hand Function Among Stroke Patients: A Scoping Review Gurav Pooja Ramesh; Manju Devi; Mani, Suresh
Sumatera Medical Journal Vol. 9 No. 2 (2026): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v9i2.21672

Abstract

Background: Delayed hand function recovery is common after stroke. Repetitive transcranial magnetic stimulation (rTMS) is an emerging non-invasive brain stimulation technique with potential for post-stroke recovery, particularly for hand function, an area with limited research. Objective: Therefore, the aim of this scoping review was to ascertain the clinical efficacy of rTMS in the recovery of hand function among stroke patients. Methods: A systematic search of PubMed, Cochrane, and ScienceDirect from 2005 to 2023 identified original research on rTMS, stroke, and hand function. The reviewers independently screened articles for eligibility, and data were extracted on rTMS intervention protocols and outcomes. Methodological quality was assessed using PEDro analysis. Results: Of 5423 titles screened, 13 studies met the inclusion criteria and were of excellent quality according to PEDro analysis. The studies used varied rTMS intervention parameters, such as frequencies (1 Hz to 20 Hz), stimulus duration (2 sec to 55 sec), numbers of stimuli (10-1000), and variable rest intervals. Conclusion: Overall, rTMS has a positive and clinically significant effect on hand function recovery, but its intervention parameters vary widely. Therefore, further research is needed to establish standardized treatment guidelines to determine the long-term effects of rTMS on motor hand function recovery.
Co-Authors Akbari Ganie, Ratna Gurav Pooja Ramesh Keumala Sari, Dina Manju Devi Meike Rachmawati Meutia Sari, Liza Muhammad, Noorzaid