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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Medfarm: Jurnal Farmasi dan Kesehatan
Sapto Yuliani
Ahmad Dahlan University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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In Vivo Identification of the Iron-Chelating Potential of Kwini Mango (Mangifera odorata Griff) Leaf Extract in Iron Overload Cases Titi Pudji Rahayu; Sapto Yuliani; Hari Susanti; Sugeng Supriyanto; Septiana Indratmoko
Jurnal Penelitian Pendidikan IPA Vol 11 No 5 (2025): May
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i5.11180

Abstract

Iron overload (IO) is a condition characterized by an abnormal accumulation of iron in the body, which affects vital organs such as the liver, heart, pancreas, and endocrine tissues. Kwini mango (Mangifera odorata Griff) leaves, which contain mangiferin (a phenolic compound), have the ability to chelate Fe3+ by promoting the oxidation of Fe2+, potentially lowering blood iron levels. This study aimed to explore the potential of kwini mango leaf extract (KMLE) as an in vivo iron chelator for treating IO, using blood samples from an IO patient. The in vivo study assessed the effects of KMLE on ferritin, SGPT, SGOT, BUN, creatinine, and serum hematology levels in blood samples. Additionally, liver and kidney histopathology were examined as markers of iron chelation. The extract's standardization was performed to determine the mangiferin content in KMLE. The in vivo results showed a decrease in ferritin, SGPT, SGOT, BUN, creatinine, and hematological parameters. Comparisons between the KMLE group, deferoxamine group, and mangiferin group indicated a significant reduction in ferritin levels in both the deferoxamine and mangiferin groups when compared to the KMLE group at doses of 50 mg/200 g BW and 100 mg/200 g BW (Asym. Sig. (2-tailed) < 0.05). A similar pattern was observed for reductions in SGPT, SGOT, BUN, and creatinine levels at the same doses (Asym. Sig. (2-tailed) < 0.05). No significant difference was observed in the KMLE group at a dose of 200 mg/200 g BW (Asym. Sig. (2-tailed) > 0.05). KMLE demonstrates the potential to reduce serum ferritin, SGOT, SGPT, BUN, creatinine, and improve liver histopathology, suggesting its effectiveness as an iron chelator for treating IO.
Mekanisme Molekuler Efek Hipolipidemik Senyawa Bioaktif dari Ekstrak Kulit Buah Alpukat (Persea americana Mill.) : Sebuah Kajian Literatur Suwahyuni Mus; Nanik Sulistyani; Sapto Yuliani
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13733

Abstract

Avocado peel (Persea americana L.) contains a number of bioactive compounds that have the potential to act as antihyperlipidemic agents. These compounds include polyphenols, flavonoids, triterpenoids, phytosterols, and phenolic acids, which are known to affect lipid metabolism through various molecular pathways. This review aims to identify the molecular mechanisms underlying the antihyperlipidemic effects of avocado peel extract. Relevant literature was obtained through searches in the PubMed, Scopus, and Web of Science databases using relevant keywords. Selected studies were analyzed based on the PICO (Population, Intervention, Comparison, Outcome) framework and summarized using the PRISMA methodology. The results of the review indicate that avocado peel extract has the potential to activate the AMPK pathway, regulate PPAR-α/γ, inhibit HMG-CoA reductase, and increase bile acid excretion. However, most of the evidence is limited to animal models and in vitro studies, and further research in humans is needed to confirm the efficacy and to elucidate more in-depth molecular mechanisms.
Antidiarrhoeal Potential of Secondary Metabolites in Betel Leaf (Piper betle): A Systematic Review with Radar Chart Analysis and AUC Evaluation. Khrisna Agung Cendekiawan; Kintoko Kintoko; Sapto Yuliani; Linda Suci Anggraeni; Firdha Aprillia Wardhani; Neny Poerwahyuningrum
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.594

Abstract

Diarrhoea is a widespread gastrointestinal disorder commonly caused by microbial infection, inflammation, or impaired intestinal function. While synthetic antidiarrhoeal drugs are available, their use is often limited by adverse effects and antimicrobial resistance, prompting increasing interest in medicinal plants such as Piper betle (betel leaf). This study systematically reviewed the literature to identify secondary metabolite compounds in Piper betle with antidiarrhoeal potential and to evaluate their biological activities using Radar Chart Analysis (RCA) and Area Under Curve (AUC) methods. A systematic search was performed across PubMed, Scopus, Web of Science, and Google Scholar using predefined keywords. Inclusion criteria comprised studies that investigated Piper betle or its secondary metabolites, reported antidiarrhoeal or related bioactivity, and provided quantitative data suitable for comparison. Studies were excluded if they focused solely on synthetic drugs, were not available in full text, or did not report measurable metabolite data. A total of 35 eligible studies were included after screening 176 records. The findings indicate that flavonoids, polyphenols, tannins, saponins, and catechins in Piper betle contribute to antidiarrhoeal effects through mechanisms that modulate intestinal motility, reduce fluid secretion, activate anti-inflammatory pathways, and exhibit antimicrobial activity. RCA and AUC analyses further demonstrated substantial variability in metabolite composition and antioxidant capacity across studies. Overall, Piper betle exhibits promising therapeutic potential as a natural antidiarrhoeal agent, although further mechanistic and clinical research is warranted.
Co-Authors Hari Susanti Khrisna Agung Cendekiawan Kintoko Kintoko Linda Suci Anggraeni Nanik Sulistyani Neny Poerwahyuningrum Septiana Indratmoko Sugeng Supriyanto Suwahyuni Mus Titi Pudji Rahayu Wardhani, Firdha Aprillia