Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA)
Sapto Yuliani
Ahmad Dahlan University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
In Vivo Identification of the Iron-Chelating Potential of Kwini Mango (Mangifera odorata Griff) Leaf Extract in Iron Overload Cases Titi Pudji Rahayu; Sapto Yuliani; Hari Susanti; Sugeng Supriyanto; Septiana Indratmoko
Jurnal Penelitian Pendidikan IPA Vol 11 No 5 (2025): May
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i5.11180

Abstract

Iron overload (IO) is a condition characterized by an abnormal accumulation of iron in the body, which affects vital organs such as the liver, heart, pancreas, and endocrine tissues. Kwini mango (Mangifera odorata Griff) leaves, which contain mangiferin (a phenolic compound), have the ability to chelate Fe3+ by promoting the oxidation of Fe2+, potentially lowering blood iron levels. This study aimed to explore the potential of kwini mango leaf extract (KMLE) as an in vivo iron chelator for treating IO, using blood samples from an IO patient. The in vivo study assessed the effects of KMLE on ferritin, SGPT, SGOT, BUN, creatinine, and serum hematology levels in blood samples. Additionally, liver and kidney histopathology were examined as markers of iron chelation. The extract's standardization was performed to determine the mangiferin content in KMLE. The in vivo results showed a decrease in ferritin, SGPT, SGOT, BUN, creatinine, and hematological parameters. Comparisons between the KMLE group, deferoxamine group, and mangiferin group indicated a significant reduction in ferritin levels in both the deferoxamine and mangiferin groups when compared to the KMLE group at doses of 50 mg/200 g BW and 100 mg/200 g BW (Asym. Sig. (2-tailed) < 0.05). A similar pattern was observed for reductions in SGPT, SGOT, BUN, and creatinine levels at the same doses (Asym. Sig. (2-tailed) < 0.05). No significant difference was observed in the KMLE group at a dose of 200 mg/200 g BW (Asym. Sig. (2-tailed) > 0.05). KMLE demonstrates the potential to reduce serum ferritin, SGOT, SGPT, BUN, creatinine, and improve liver histopathology, suggesting its effectiveness as an iron chelator for treating IO.
Mekanisme Molekuler Efek Hipolipidemik Senyawa Bioaktif dari Ekstrak Kulit Buah Alpukat (Persea americana Mill.) : Sebuah Kajian Literatur Suwahyuni Mus; Nanik Sulistyani; Sapto Yuliani
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13733

Abstract

Avocado peel (Persea americana L.) contains a number of bioactive compounds that have the potential to act as antihyperlipidemic agents. These compounds include polyphenols, flavonoids, triterpenoids, phytosterols, and phenolic acids, which are known to affect lipid metabolism through various molecular pathways. This review aims to identify the molecular mechanisms underlying the antihyperlipidemic effects of avocado peel extract. Relevant literature was obtained through searches in the PubMed, Scopus, and Web of Science databases using relevant keywords. Selected studies were analyzed based on the PICO (Population, Intervention, Comparison, Outcome) framework and summarized using the PRISMA methodology. The results of the review indicate that avocado peel extract has the potential to activate the AMPK pathway, regulate PPAR-α/γ, inhibit HMG-CoA reductase, and increase bile acid excretion. However, most of the evidence is limited to animal models and in vitro studies, and further research in humans is needed to confirm the efficacy and to elucidate more in-depth molecular mechanisms.
Co-Authors Hari Susanti Nanik Sulistyani Septiana Indratmoko Sugeng Supriyanto Suwahyuni Mus Titi Pudji Rahayu