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All Journal Bionature Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam
Shopia Salsabila
Universitas Negeri Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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THE EFFECT OF MATOA (Pometia pinnata) LEAVES ETHANOL EXTRACT ON REDUCING CHOLESTEROL LEVELS IN MALE MICE(Mus musculus) MuhammadNaufal Syaiful Haq; Halifah Pagarra; Abd Muis; Shopia Salsabila
SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam Vol. 14 No. 01 (2025): Volume 14 Nomor 1 (Maret 2025)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/j72heg19

Abstract

This research aims to determine the total phenolic content and antioxidant activity of the ethanol extract of matoa (Pometia pinnata) leaves and their effect on the cholesterol levels of male mice (Mus musculus). To determine the total phenolic content using the Folin-Ciocalteu method and the DPPH method to measure antioxidant activity. The effect of matoa leaf extract on reducing cholesterol levels in mice used a completely randomized design (CRD) with 15 mice divided into 5 treatment groups with 3 replications, namely P1 (Extract 175 mg/kgBW), P2 (Extract 350 mg/kgBW), P3 (Extract 700 mg/kgBW), K+ (Simvastatin 0.10 mg/kgBW), and K-(Na-CMC 1%). Extraction uses the maceration method with 70% ethanol solvent. The total phenolic test results were 26.24872 mgGAE/g. The results of measuring antioxidant activity obtained an IC50 of 1,961 ppm. The results of testing cholesterol levels showed that there was an effect of giving ethanol extract of Matoa (Pometia pinnata) leaves on reducing cholesterol levels in male mice (Mus musculus). Giving ethanol extract of Matoa leaves at a dose of 350 mg/kgBW is effective in reducing cholesterol levels. So it can be concluded that the ethanol extract of Matoa leaves has an effect on reducing cholesterol levels in male mice
The Effect of Matoa (Pometia Pinnata) Leaf Ethanol Extract on Reducing Blood Sugar Level in Male Mice (Mus Musculus) Induced by Alloxan Halifah Pagarra; Shopia Salsabila; Abd Muis; Muhammad Naufal Syaiful Haq
Bionature Vol. 26 No. 1 (2025): April-Juni 2025
Publisher : Jurusan Biologi Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v26i1.7361

Abstract

This research aims to determine the total phenolic content and antioxidant activity of the ethanol extract from Matoa (Pometia pinnata) leaves as well as its effect on blood sugar levels in male mice (Mus musculus) induced with alloxan. To determine total phenolic content using the Folin-Ciocalteu method, and the DPPH method to measure antioxidant activity. The effect of Matoa leaves on blood sugar reduction in mice used a completely randomized design (CRD) with 15 mice divided into 5 treatments with 3 replications: namely P1 (Extract 125 mg/kg BW), P2 (Extract 250 mg/kg BW), P3 (Extract 500 mg/kg BW), K+ (Glibenclamide), and K- (Na-CMC 0.5%). Extraction used the maceration method with 70% ethanol solvent. The results of the total phenolic test showed the presence of phenolics with a value of 26.24872 mg GAE/g. The measurement of antioxidant activity yielded an IC50 value of 1.961 ppm. The results of testing the blood sugar levels showed that there was an effect of giving ethanol extract of Matoa (Pometia pinnata) leaves on reducing blood sugar levels in male mice (Mus musculus). Giving of ethanol extract of Matoa leaves at a dose of 250 mg/kg BW is effective in reducing blood sugar levels. So it can be concluded that the ethanol extract of Matoa leaves has an effect on reducing blood sugar levels in male mice
Co-Authors Abd Muis Muhammad Naufal Syaiful Haq MuhammadNaufal Syaiful Haq Pagarra, Halifah