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All Journal JURNAL FARMASIMED (JFM) Jurnal Ilmiah Farmako Bahari Medical Sains : Jurnal Ilmiah Kefarmasian
Moch Saiful Bachri
Universitas Ahmad Dahlan
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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FORMULATION OF HAIR TONIC COMBINATION OF ETHANOL EXTRACTS OF MORINGA OLEIFERA LAM LEAVES AND FRAGRANT PANDAN (Pandanus Amaryllifolius Roxb) AND ITS ACTIVITY ON HAIR GROWTH IN WHITE RATS Reski Mulia; Iis Wahyuningsih; Moch Saiful Bachri; Sri Mulyaningsih
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1202

Abstract

Hair is the crown for everyone because hair functions aside from providing warmth, protection, beauty, and support. Hair loss that can cause baldness is one of the most serious problems for everyone. This study aimed to determine the activity of Hair Tonic combination formulations of kelor leaf ethanol extract (Moringa oleifera Lam.) and ethanol extracts of Fragrant Pandan  leaves (Pandanus amaryllifolius Roxb) on rat hair growth compared to single use. The method began with the maseration process of ethanol extract of kelor leaves and ethanol extract of Fragrant Pandan leaves, characterization of extracts (specific and non-specific parameters), chemical content testing of extracts and formulation of Hair Tonic preparations consisting of F1 (positive control), F2 (6% kelor leaf extract), F3 (6% ethanol pandan extract), F4 (combination of 2% kelor leaf extract with 4% ethanol pandan extract), F5 (3% kelor leaf ethanol extract and 3% ethanol pandan leaf extract), F6 (combination of 4% kelor leaf ethanol extract and 2% ethanol pandan leaf extract). The rat hair growth activity was divided into 8 groups: each rat's back was shaved to a size of 4 × 4 cm, the rats were left for 24 hours and then testing was carried out by spraying each formula, and hair growth was observed for 28 days. ...
Combination of Essential Oils of Ylang-Ylang (Cananga Odorata), Jasmine (Jasminum Sambac), and Mint Leaves (Mentha Piperita) TestingAphrodisiac on Male Mice Formulated in Candle Forms Tio Widia A. marpaung; Kintoko; Wahyu Widyaningsih; Moch Saiful Bachri; Amelia Regina Arsyad
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7q01y176

Abstract

This study explored the potential of Jasminum sambac (jasmine) and Mentha piperita (peppermint) as natural sexual stimulants (aphrodisiacs) to enhance sexual activity in males and females through the use of essential oils. The main objective was to identify the most effective combination of essential oil formulations, which were evaluated through several biological and physiological parameters, including sexual behavior in mice, sperm quality, testicular histopathology, and wax-based formulations as the delivery medium. Three formulations were tested: P1 (3:1:1), P2 (1:3:1), and P3 (1:1:3), administered to mice using a humidifier via inhalation. Sexual behavior was assessed through mounting latency and mounting frequency as indicators of libido. Sperm quality parameters included morphology, motility, viability, and sperm count. Testicular histopathology was examined to evaluate tissue structure and spermatogenesis activity. The results demonstrated that the P1 formulation was the most effective, showing the highest aphrodisiac activity. In the sexual behavior test, P1 recorded an activity value of 21±6.2, indicating enhanced libido. Sperm quality testing also confirmed the superiority of P1, with the lowest sperm abnormalities (5.3±1.53), highest motility (82±7.5), highest viability (85.6±4.58), and the greatest sperm count (53,300±16,653.3). Although testicular histopathology revealed a slight reduction in spermatogenic cells across all treatment groups, the change was not significant in the P1 group compared to the control. Overall, the P1 formulation improved libido and sperm quality more effectively than P3 and the control group, indicating its potential to be developed as an aphrodisiac preparation based on natural essential oils.
Acute Toxicity Test of Black Rice and Soybean Extract Complex Liza Syafitri; Nina Salamah; Ichwan Ridwan Rais; Kintoko Kintoko; Sri Mulyaningsih; Moch Saiful Bachri
Jurnal Ilmiah Farmako Bahari Vol 17 No 2 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i2.43524

Abstract

The present study was conducted to assess the acute oral toxicity of a copigment complex formulated from extracts of black rice (Oryza sativa L., indica) and soybean (Glycine max (L.) Merr.). Despite extensive individual pharmacological investigations of these botanical sources, no safety data have previously been documented for their combined copigment complex intended as a functional beverage constituent. Following the Acute Toxic Class methodology (OECD 423), the complex was orally administered as a single dose at 300, 2000, or 5000 mg/kg body weight (BW) to female Swiss Webster mice (n=3 per dose group), alongside a vehicle control group administered 1% Na-CMC. A comprehensive 14-day monitoring program assessed mortality, a range of clinical indicators (including tremor, convulsions, salivation, diarrhea, lethargy, locomotion, coat condition, and ocular appearance), and body weight at Days 0, 7, and 14. No animal deaths occurred across any group. Transient, mild hypoactivity was noted in animals receiving 5000 mg/kg at 1–2 hours post-dose, which resolved completely by 4 hours post-administration. No additional adverse clinical manifestations or weight loss were detected. Based on these findings, the median lethal dose (LD50) is projected to surpass 5000 mg/kg BW, corresponding to GHS Category 5 (practically non-toxic). The results collectively establish a safety foundation for the use of this copigment complex as a functional ingredient in isotonic beverage products, while acknowledging the need for further subchronic and chronic toxicological investigations.
Co-Authors Amelia Regina Arsyad Ichwan Ridwan Rais Iis Wahyuningsih Kintoko Kintoko, Kintoko Liza Syafitri Nina Salamah Reski Mulia Sri Mulyaningsih Tio Widia A. marpaung Wahyu Widyaningsih