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All Journal JURNAL FARMASIMED (JFM) Lumbung Farmasi : Jurnal Ilmu Kefarmasian
Muhammad Andy Rajab
Universitas Ahmad Dahlan
Health Professions Medicine & Pharmacology

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Antioxidant Potential of the Asteraceae Family in Counteracting Free Radicals in Cigarette Smoke: An Overview Aulia Syafadilla Azali; Muhammad Andy Rajab; Sofiani Lathifah; Akrom
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4vbm3x10

Abstract

Cigarette smoke exposure triggers oxidative stress in the respiratory system through an increase in free radicals and a decrease in endogenous antioxidant activity, which contributes to lung damage and chronic diseases such as COPD and lung cancer. This study aims to investigate the potential of species from the Asteraceae family as a source of natural antioxidants in protecting the lungs and trachea from damage caused by exposure to free radicals in cigarette smoke. The method used is a Systematic Literature Review (SLR) with reference to the PRISMA 2020 guidelines. Literature searches were conducted systematically through the PubMed, ScienceDirect, and Google Scholar databases until June 2025. The inclusion criteria included in vivo studies using Asteraceae plant extracts in animals with induced oxidative stress in the respiratory system, as well as involving the measurement of biomarkers such as MDA, GSH, SOD, and CAT. Of the 198 articles found, 10 articles met the criteria and included species such as Tridax procumbens, Chromolaena odorata, Pulicaria petiolaris, and Baccharis retusa. The results showed that these species had significant antioxidant activity through their flavonoid, polyphenol, and triterpenoid compound content. However, most studies did not use a direct cigarette smoke exposure model. In conclusion, the Asteraceae family has great potential as a source of natural antioxidants to protect the respiratory system from oxidative stress, although further research with more relevant exposure models is needed. Toxicology and metabolomics approaches are also needed to strengthen the evidence for practical application in the treatment of lung diseases caused by cigarette smoke.
Potensi Famili Zingiberaceae Sebagai Terapi Kanker Payudara : Review Aulia Syafadilla Azali; Arini Salsabila; Muhammad Andy Rajab; Moch Saiful Bachri; Dian Prasasti; Nina Salamah
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 2 (2026): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i2.39641

Abstract

Kanker payudara merupakan penyebab utama kematian pada perempuan secara global, termasuk di Indonesia. Meskipun terapi konvensional seperti kemoterapi dan terapi target telah digunakan secara luas, efektivitasnya masih terbatas dan sering menimbulkan efek samping serius. Dalam konteks ini, pemanfaatan tanaman obat mulai menjadi perhatian karena potensi bioaktifnya dan harapan untuk menghadirkan pilihan terapi yang lebih aman serta terjangkau. Kajian ini bertujuan mengidentifikasi dan memahami bukti ilmiah terkini mengenai potensi antikanker tanaman dalam famili Zingiberaceae terhadap kanker payudara serta mekanisme molekuler yang mendasarinya. Artikel ini merupakan narrative review terhadap 18 literatur ilmiah dari basis data PubMed, Scopus, ScienceDirect, dan Google Scholar yang membahas efek antikanker tanaman Zingiberaceae pada sel kanker payudara tipe luminal (MCF-7 dan T47D) serta triple-negative (MDA-MB-231 dan 4T1). Hasil kajian menunjukkan bahwa tanaman famili Zingiberaceae berpotensi sebagai sumber kandidat agen antikanker payudara melalui berbagai mekanisme molekuler. Aktivitas antikanker ditunjukkan oleh nilai IC₅₀ yang bervariasi antarspesies, mencerminkan perbedaan potensi sitotoksik. Di antara seluruh spesies yang dikaji, Boesenbergia rotunda menunjukkan potensi paling kuat dengan nilai IC₅₀ sebesar 5,62 µg/mL. Selain itu, diperlukan standardisasi metode ekstraksi, karakterisasi senyawa aktif, dan parameter pengujian untuk meningkatkan konsistensi hasil penelitian serta memperkuat bukti ilmiah terkait potensi famili Zingiberaceae sebagai sumber kandidat agen antikanker payudara.
Co-Authors Akrom Arini Salsabila Aulia Syafadilla Azali Aulia Syafadilla Azali Dian Prasasti Moch Saiful Bachri Nina Salamah Sofiani Lathifah