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All Journal Borneo Journal Of Pharmascientech Journal of Pharmaceutical and Sciences.
Muhammad Hidayatullah
Universitas Borneo Lestari
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Uji Aktivitas Antioksidan Ekstrak Etanol 96% Daun Karamunting (Melastoma malabathricum L.) dengan Metode CUPRAC Nabila Saputri; Rahmi Muthia; Muhammad Hidayatullah
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.486

Abstract

Free radicals are compounds that can damage cellular structures in the body, including DNA, lipids and proteins. Antioxidants are compounds that can inhibit the oxidation process. Karamunting leaves (Melastoma malabathricum L.) a plant that can be used as a natural antioxidant source. The purpose of this study was to determine the content of secondary metabolites contained in 96% ethanol extract of caramunting leaves and to determine the EC50 value obtained from the antioxidant activity test of caramunting leaf extract tested quantitatively using the CUPRAC (Cupric Ion Reducing Antioxidant Capacity) method. Karamunting leaves (Melastoma malabathricum L.) were extracted using maceration method with 96% ethanol solvent. Testing the antioxidant activity of caramunting leaves using the CUPRAC (Cupric Ion Reducing Antioxidant Capacity) method with a UV-Vis spectrophotometer with quercetin as a comparison. The quercetin test for comparison is with a concentration of 1; 2; 3; 4; 5; ppm and extract samples with a concentration of 25; 50; 75; 100; 125; ppm. In the phytochemical screening test, positive results were obtained for containing antioxidants in the test for alkaloids, phenols, flavonoids, saponins, steroids, tannins. The results of the study showed that the EC50 with quercetin was 3.8059 ppm and the EC50 value of 96% ethanol extract of caramunting leaves (Melastoma malabathricum L.) was 61.6185 ppm. In conclusion, 96% ethanol extract of karamunting leaves is classified as a strong antioxidant activity.
Uji Aktivitas Antioksidan Kombucha Daun Kelakai (Stenochlaena palustris (Burm.F) Bedd) Dengan Metode DPPH Muhammad Hidayatullah; Abdurrahman Abdurrahman; Lisa Andina; Rini Astiati; Rina Rina
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1256

Abstract

Degenerative diseases are often caused by exposure to free radicals, and antioxidants play an important role in maintaining body stability by counteracting them. Kelakai (Stenochlaena palustris), a typical plant of Kalimantan, contains bioactive compounds such as phenolics and flavonoids, making it a potential source of natural antioxidants. This study aims to determine the results of antioxidant activity tests on kelakai leaf kombucha. Kombucha was chosen because its antioxidant activity is influenced by the phenolic content formed during fermentation, potentially becoming an antioxidant-rich probiotic drink. The antioxidant activity test of kelakai leaf kombucha used the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The results of determining the maximum absorption wavelength of 0.1 mM DPPH were at 515 nm with the highest absorption of 0.602. The antioxidant activity test using quercetin as a comparison resulted in an IC₅₀ value of 3.0892 ppm. This quercetin IC₅₀ value is included in the very strong category (<50 ppm). Meanwhile, the antioxidant activity test on kelakai leaf kombucha yielded an IC₅₀ value of 0.5845 ppm. This value also indicates that kelakai leaf kombucha has very strong antioxidant activity. Increasing sample concentration is directly proportional to the increase in antioxidant activity, as indicated by a decrease in the absorption value. Therefore, the development of kelakai leaf kombucha and testing its antioxidant activity are expected to produce innovative functional food products.
Co-Authors Abdurrahman Abdurrahman Lisa Andina Nabila Saputri Rahmi Muthia Rina Rina Rini Astiati