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All Journal Gravity : Jurnal Ilmiah Penelitian dan Pembelajaran Fisika
Hafiz Sub’han
Universitas Negeri Malang
Astronomy Earth & Planetary Sciences Education Materials Science & Nanotechnology Physics

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Comparison of Microstructures and Magnetic Characteristics of CoFe2O4/PEG and MnFe2O4/PEG for Drug Delivery System Application Joko Utomo; Hafiz Sub’han
Gravity : Jurnal Ilmiah Penelitian dan Pembelajaran Fisika Vol 10 No 1 (2024)
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30870/gravity.v10i1.28748

Abstract

CoFe2O4/PEG and MnFe2O4/PEG materials have been successfully prepared using the coprecipitation method with a synthesis temperature of 90 °C. Doxorubicin (DOX) was successfully loaded and released in both samples. Based on the XRD results, the crystal structure of CoFe2O4/PEG is cubic spinel while the structure of MnFe2O4/PEG is hematite with the lattice parameters for CoFe2O4/PEG and MnFe2O4/PEG is 8.40 nm and 8.41 nm, respectively. Based on the SEM results, the morphology of the two samples is quite homogenous and the particle size of CoFe2O4/PEG is smaller than MnFe2O4/PEG’s. There is a vibrational spectrum of Fe – O  in both samples at wave numbers of 600 - 690 cm-1. Based on VSM characterization, CoFe2O4/PEG is included in hard magnetic materials with a saturation magnetization of 54.85 emu/g and coercivity of 788 Oe. Meanwhile, MnFe2O4/PEG is classified as soft magnetic materials with lower saturation magnetization of 11 emu/g and coercivity of 7.42. In addition, based on the UV-Vis characterization obtained the efficiency of drug loading of CoFe2O4/PEG is higher (98.8 %) than the MnFe2O4/PEG sample (96.3 %). It is the opposite for the drug release percentage that CoFe2O4/PEG has 30.6 % which is lower than the MnFe2O4/PEG (51.6 %).
Co-Authors Joko Utomo