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All Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Sciences and Clinical Pharmacy Research Journal
Adhi Wardhana Amrullah
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Health Professions Medicine & Pharmacology Nursing Public Health

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Identifikasi Potensi Interaksi Pada Pasien Dewasa Diabetes Melitus Tipe 2 Dengan Hipertensi Di RSUD DR. Moewardi Surakarta Neni Zakiyah; Adhi Wardhana Amrullah; Rolando Rahardjoputro
Sciences and Clinical Pharmacy Research Journal Vol. 1 No. 3 (2024): October
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v1i3.3163

Abstract

Diabetes melitus adalah suatu gangguan metabolik yang ditandai dengan peningkatan kadar glukosa darah (hiperglikemia) akibat kerusakan pada sekresi insulin dan kerja insulin. Hipertensi adalah peningkatan tekanan darah yang tidak normal ditandai dengan tekanan darah diatas 140/90 mmHg. Diabetes melitus seringkali disertai dengan hipertensi atau sebaliknya. Hal ini menyebabkan penggunaan banyak obat yang berbeda dan cenderung mendorong interaksi obat. Interaksi obat adalah interaksi yang terjadi ketika efek suatu obat diubah oleh efek obat lain. Penelitian ini bertujuan untuk mengetahui potensi terjadinya interaksi pada pasien dewasa diabetes melitus tipe 2 dengan hipertensi di instalasi rawat inap RSUD Dr. Moewardi Surakarta periode Januari sampai Desember 2023. Jenis penelitian ini adalah deskriptif observasional dengan rancangan cross sectional, memperoleh data secara retrospektif dan analisis interaksi obat menggunakan software drugs.com versi 2.14.11. Pengambilan sampel secara purposive sampling. Kriteria inklusi yaitu pasien berumur 18-59 tahun, pasien yang menjalani rawat inap, menerima sedikitnya satu jenis obat antihipertensi dan satu jenis obat antidiabetes. Kriteria eksklusi yaitu pasien dengan data rekam medis tidak lengkap atau tidak terbaca, pasien yang meninggal selama perawatan. Hasil penelitian potensi terjadinya interaksi pada pasien dewasa diabetes melitus tipe 2 dengan hipertensi di RSUD Dr. Moewardi Surakarta dari 100 pasien terdapat 90 pasien yang ada interaksi obat. Interaksi obat berdasarkan tingkat keparahan minor sebanyak 20 (5,10%), moderate sebanyak 340 (86,30%) dan major sebanyak 34 (8,60%). Interaksi obat berdasarkan pola mekanisme farmakokinetik sebanyak 12 (3,00%), farmakodinamik sebanyak 318 (80,70%) dan unknown sebanyak 64 (16,20%).
Potensi Interaksi Obat pada Pasien Geriatri Diabetes Melitus Tipe 2 di RSUD Dr. Moewardi Surakarta Tahun 2023 Dilla Ayu Septiyani; Adhi Wardhana Amrullah; Rolando Rahardjoputro
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.674

Abstract

Type 2 diabetes mellitus represents a persistent metabolic dysfunction marked by elevated blood glucose levels attributable to insulin resistance. Geriatrics pertains specifically to individuals aged 60 years and older. Managing diabetes mellitus necessitates intricate therapeutic interventions, often comprising single or combined pharmacological agents aimed at achieving euglycemia. The concurrent administration of multiple medications, termed polypharmacy, amplifies the likelihood of pharmacological interactions. This investigation endeavors to delineate potential drug interactions observed in geriatric inpatients afflicted with type 2 diabetes mellitus at Dr. Moewardi Regional General Hospital in Surakarta throughout the calendar year 2023. The study adopted a descriptive observational design employing a cross-sectional approach. Data collection was conducted retrospectively through purposive sampling based on the medical records of geriatric patients at Dr. Moewardi Regional General Hospital in Surakarta. Inclusion criteria encompassed patients aged 60 years and older diagnosed with type 2 diabetes mellitus who had been hospitalized. Exclusion criteria included incomplete or illegible medical records, patients diagnosed with anemia and hemoglobinopathies, and those who expired during treatment. The findings revealed that out of 100 patients, 96 experienced drug interactions. Most patients (47.00%) were aged between 66 and 74 years. Females constituted a larger proportion (51.00%) of the patient cohort. Among hospitalized patients, 83 (83.00%) were admitted for 2-6 days. A total of 70 patients (70.00%) were prescribed between 4 and 13 medications. The predominant severity level of drug interactions was moderate, comprising 1,017 cases (74.60%). Pharmacodynamic mechanisms accounted for most drug interactions observed, totaling 1,054 cases (77.30%).
Tingkat Kepuasan Pengunjung Apotek Terhadap Pelayanan Kefarmasian di Beberapa Apotek Kabupaten Karanganyar Novia Amalia; Rolando Rahardjoputro; Adhi Wardhana Amrullah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.702

Abstract

Health is a pivotal factor in enhancing human quality of life by improving healthcare service quality. Pharmacies serve as crucial healthcare facilities widely frequented by the populace. High-quality pharmaceutical services in pharmacies can gratify patients, foster patient loyalty, and augment patient quality of life. This study aims to ascertain patient satisfaction levels regarding pharmaceutical services at several pharmacies in Karanganyar Regency. This descriptive observational study employed a quantitative approach. Sampling was conducted using non-probability sampling with an accidental sampling technique, resulting in a sample of 105 respondents. Patient satisfaction levels were computed using SPSS Statistics 25. Research findings revealed satisfaction rates for pharmacy service indicators: pharmacy appearance achieved 85.10% (very satisfied), staff friendliness achieved 80.23% (very satisfied), medication information provision achieved 82.66% (very satisfied), medication availability achieved 83.27% (very satisfied), and service speed achieved 87.93% (very satisfied). In conclusion, patients expressed overall satisfaction with pharmaceutical services at several pharmacies in Karanganyar Regency.
Co-Authors Dilla Ayu Septiyani Neni Zakiyah Novia Amalia Rolando Rahardjoputro