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EVALUASI EFEKTIVITAS DEKSAMETASON VERSUS PREDNISON UNTUK MENGURANGI EKSASERBASI DAN MENURUNKAN ANGKA RELAPS ASMA AKUT PADA ANAK DENGAN KAJIAN SYSTEMATIC REVIEW Rolando Rahardjoputro; Erinda Nur Pratiwi; Inayatush Sholihah
Jurnal Ilmu Kebidanan dan Kesehatan (Journal of Midwifery Science and Health) Vol. 13 No. 1 (2022): Jurnal Ilmu Kebidanan dan Kesehatan (Journal of Midwifery Science and Health)
Publisher : Sekolah Tinggi Ilmu Kesehatan Bakti Utama Pati

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (555.814 KB) | DOI: 10.52299/jks.v13i1.92

Abstract

Pengendalian kekambuhan asma dan kejadian relaps pada anak – anak merupakan salah satu poin pentingdalam tatalaksana asma. Tujuan sistematik review ini adalah untuk mengetahui efektivitas penggunaandeksametason dibandingkan dengan prednison untuk mengurangi gejala eksaserbasi asma akut sertamenurunkan angka relaps pada pasien anak-anak. Uji coba diperiksa berdasarkan kriteria inklusi daneksklusi yang telah dirancang sebelumnya. Pada analisis Forest Plot didapatkan RR sebesar 0,97 padaperbandingan efektifitas prednison dengan deksametason untuk mengurangi gejala eksaserbasi asma akutpada anak – anak. RR sebesar 1,37 untuk perbandingan efektivitas dalam mengurangi kejadian relapsasma akut pada anak – anak. Dari 3 jurnal yang telah di bahas, didapatkan hasil tidak berbeda bermaknadari efektifitas deksametason dengan prednison dalam mengurangi gejala eksaserbasi asma akut padaanak – anak dan mengurangi kejadian relaps asma
Evaluasi Rasionalitas Penggunaan Antibiotik pada Pasien dengan Infeksi Saluran Kemih di Rumah Sakit X di Surakarta Adhi Wardhana Amrullah; Avianti Eka Dewi Aditya Purwaningsih; Rolando Rahardjoputro; Atiek Murharyati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 12, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.73613

Abstract

The study was conducted by evaluating the rationality of antibiotics as an indicator of the rationality of antibiotic administration with the aim of knowing the level of rationality of the pattern of prescribing antibiotics for urinary tract infections The rationality analysis method of prescribing antibiotics in this study used the Gyssens method as a method in medical research used to determine the rationality of antibiotic administration. This research is a descriptive observational study with a cross-sectional method. The data was obtained from a retrospective search of medical records from January to December 2020 at the medical records section of the Hospital in Surakarta. The results showed that the number of patients with urinary tract infections who were hospitalized during 2020 was 104 patients and the number of patients who received antibiotic prescriptions was 80 patients. The results of rationality analysis showed that the antibiotics used in patients with urinary tract infections were 27 (33.75%) cases of antibiotic use including category 0 (zero) which means rational use of antibiotics. Irrational use of antibiotics occurred in category III-A as 40 cases (50%), II-B as 11 cases (13.75%), and the combination of II B with III A as 2 cases (2.5%).
PENGARUH STABILITAS FISIK KRIM EKSTRAK DAUN KELOR (Moringa oleifera, Lamk.) TERHADAP VARIASI VASELIN ALBUM SEBAGAI OABAT JERAWAT joko santoso; Lanny Triana; Rr. Sri Wulandari; Ersta Zusvita; Dheny Rohmatika; Agnes Prameswari; Rolando Rahardjo
Jurnal Kesehatan Kusuma Husada Vol. 11 No. 2, Juli 2020
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.924 KB) | DOI: 10.34035/jk.v11i2.834

Abstract

Daun kelor (Moringa oleifera Lamk.) mengandung flavonoid dan tannin berfungsi sebagai tanaman obat yang berkhasiat untuk mengobati jerawat. Sekarang ini daun kelor (Moringa oleifera Lamk.) digunakan oleh masyarakat dengan cara dibuat serbuk untuk masker wajah sebagai obat jerawat, dengan cara ini masih menggunakkan cara konvensional dan cara pembuatannya sangat tidak praktis. Tujuan : Mengetahui pengaruh variasi basis vaselin album terhadap uji stabilitas fisik krim ekstrak daun kelor (Moringa oleifera Lamk.). Metode : penelitian ini merupakan penelitian eksperimental dengan menggunakkan variabel independent dna variabel dependent. Penelitian ini meliputi ekstraksi maserasi . krim dibuat dalam 3 formula. Formula I dengan konsentrasi vaselin album 4 g dan formulasi II dengan konsentrasi 8 g dan formulasi III vaselin album 16 g. Krim yang telah dibuat kemudian dilakukan uji kontrol kualitas yang meliputi uji organoleptis, uji daya sebar, uji daya lekat, dan uji pH. Hasil : Menunjukkan bahwa bahwa formulasi krim ekstrak daun kelor yang paling memenuhi standar sifat fisik krim setelah dilakukan adalah Formula II dengan basis vaselin album 8 gram ditunjukkan dengan hasil organoleptis konsistensi lunak ,ditunjukkan dengan pH 6,5, daya sebar 6 cm, daya lekat 4”64 dibandingkan dengan Formula I dan III. Kesimpulan : Ekstrak daun kelor (Moringa oleifera Lamk.) dapat diformulasikan menjadi sediaan krim dengan konsentrasi basis vaselin album 8 gram yang stabil secara fisik. Moringa leaves (Moringa oleifera Lamk.) contain flavonoids and tannins that function as medicinal plants that are efficacious for treating acne. Currently, Moringa leaves (Moringa oleifera Lamk.) are used by the community by making powder for face masks as acne medicine, in this way still using conventional methods and the method of making it is very impractical. Objective : To determine the effect of variations in Vaseline album base on the physical stability test of Moringa leaf extract cream (Moringa oleifera Lamk.). Methods: this research is an experimental study using independent variables and dependent variables. This research includes maceration extraction. The cream is made in 3 formulas. Formula I with a concentration of 4 g vaseline album and formulation II with a concentration of 8 g and formulation III with 16 g of vaseline albumin. The cream that has been made is then subjected to quality control tests which include organoleptic tests, dispersibility tests, adhesion tests, and pH tests. Results: Indicates that the formulation of Moringa leaf extract cream that best meets the standards of the physical properties of the cream after it has been done is Formula II with a base of 8 gram vaseline album indicated by soft consistency organoleptic results, indicated by pH 6.5, spreadability 6 cm, adhesion 4 ”64 compared to Formula I and III. Conclusion : Moringa leaf extract (Moringa oleifera Lamk.) can be formulated into a cream preparation with a physically stable concentration of 8 gram Vaseline album base.
Ketepatan Pemilihan Peresepan Antibiotik untuk Terapi Pneumonia pada Pasien Lansia Rawat Inap di Rumah Sakit X Surakarta: The Appropriate Selection of Antibiotic Prescriptions for Pneumonia Therapy in Elderly Inpatients at X Hospital Surakarta Rolando Rahardjoputro; Inayatush Sholihah; Adhi Wardhana Amrullah
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.545 KB) | DOI: 10.35473/ijpnp.v6i01.2152

Abstract

Pneumonia is an infectious disease often suffered by geriatric patients in Indonesia and the world. The aim is to analyze the rationality of antibiotics for pneumonia in geriatric inpatients. The rational analysis method for prescribing antibiotics in this study uses the Gyssens method as one of the methods in medical research used to determine the rationale for administering antibiotics. This research is a descriptive observational study with a cross-sectional method. Data were obtained from a retrospective search of medical records from January to December 2020 in the medical records section of Hospital X Surakarta. The results showed that the use of most antibiotics for geriatric patients with pneumonia were levofloxacine (60%), ceftriaxone (26.67%), cefotaxime (13.34%), ceftazidime (13.34%), and azithromycin (13.34%) ). The rationality analysis of Gyssens method obtained IVA category 33.34%, IVB category 60% and 0 category 6.66%. It can be concluded that prescribing antibiotics for pneumonia in geriatric patients hospitalized at X Hospital Surakarta is still not rational. ABSTRAK Pneumonia merupakan penyakit infeksi yang sering diderita oleh pasien geriatri di Indonesia dan dunia. Tujuan penelitian ini yaitu menganalisis rasionalitas antibiotik untuk pneumonia pada pasien geriatri rawat inap. Metode analisis rasionalitas peresepan antibiotik pada penelitian ini menggunakan metode Gyssens sebagai salah satu metode dalam penelitian kesehatan yang digunakan untuk menentukan rasionalitas pemberian antibiotik. Penelitian ini merupakan penelitian observasional deskriptif dengan metode cross-sectional. Data diperoleh dari penelusuran retrospektif rekam medis periode Januari hingga Desember tahun 2020 di bagian rekam medis Rumah Sakit X Surakarta. Hasil: Hasil penelitian menunjukkan bahwa penggunaan antibiotik terbanyak  pada pasien geriatri dengan pneumonia adalah levofloksasin (60%), seftriakson (26,67%), sefotaksim (13,34%), seftazidim (13,34%), dan azitromisin (13,34%). Analisis rasionalitas metode Gyssens diperoleh kategori IVA 33,34%, kategori IVB 60% dan kategori 0 6,66%. Dapat disimpulkan bahwa peresepan antibiotik untuk pneumonia pada pasien geriatri yang rawat inap di rumah sakit X Surakarta masih belum rasional.
HUBUNGAN MAKANAN PENDAMPING ASI DINI DAN PERAN KADER TERHADAP TUMBUH KEMBANG BAYI USIA 0-6 BULAN Erna Wati; Dheny Rohmatik; Frieda Ani Noor; Rolando Rahardjoputro
Medika Respati : Jurnal Ilmiah Kesehatan Vol 18, No 3 (2023)
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35842/mr.v18i4.578

Abstract

Latar belakang: Makanan pendamping ASI adalah makanan tambahan yang diberikan pada bayi setelah usia 6 bulan. Jika makanan pendamping ASI diberikan terlalu dini (sebelum usia 6 bulan) akan menurunkan konsumsi ASI dan bayi bisa mengalami gangguan pencernaan. Namun sebaliknya jika makanan pendamping ASI diberikan terlambat akan mengakibatkan bayi kurang gizi, bila terjadi dalam waktu panjang (Hendras, 2010). Bayi usia dini sangat rentan terhadap bakteri penyebab diare, terutama di lingkungan yang kurang higienes dan sanitasi buruk. Tujuan: Menganalisis hubungan pemberian makanan pendamping ASI dini terhadap tumbuh  kembang bayi usia 0-6 bulan Posyandu Desa Bangsalan Teras Boyolali. Metode : Penelitian ini menggunakan metode kuantitatif, analitik observasional dengan pendekatan cross sectional. Sampel adalah semua ibu yang mempunyai bayi usia kurang dari 6 bulan yang berada di Desa Bangsalan. Teknik pengambilan sampel menggunakan total sampling. Analisis data menggunakan uji regresi logistik. Hasil: Terdapat pengaruh yang signifikan antara pemberian makanan pendamping ASI dini dan peran kader terhadap tumbuh  kembang bayi usia 0-6 bulan Posyandu Desa Bangsalan Teras Boyolali. Hasil analisa regresi linier nilai F hitung sebesar 5.886, dimana nilai tersebut lebih besar dari nilai F tabel yaitu (3.18). Kesimpulan: Terdapat pengaruh yang signifikan antara pemberian makanan pendamping ASI dini dan peran kader terhadap tumbuh  kembang bayi usia 0-6 bulan.
Promosi Teh Hijau sebagai Minuman Kesehatan untuk Masyarakat Kecamatan Jebres, Kota Surakarta Sardjiman, Sardjiman; Rahardjoputro, Rolando; Santoso, Joko; Widyaningrum, Nova Rahma
Kapas: Kumpulan Artikel Pengabdian Masyarakat Vol 2, No 3 (2024)
Publisher : Universitas Indraprasta PGRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30998/ks.v2i3.2178

Abstract

Teh hijau telah lama digunakan oleh masyarakat sebagai minuman hangat untuk bersantai maupun sebagai pengobatan beberapa masalah kesehatan tertentu. Berbagai khasiat teh hijau terhadap tubuh menempatkan teh hijau sebagai salah satu minuman pilihan untuk kesehatan tubuh. Kegiatan promosi kesehatan ini dilaksanakan di salah satu kelurahan di kecamatan Jebres, Kota Surakarta dengan peserta ibu – ibu PKK kelurahan berjumlah 59 orang. Pada kegiatan pengabdian masyarakat ini akan dilakukan promosi kesehatan terhadap masyarakat dengan metode presentasi. Pemberian informasi mengenai teh hijau dilakukan secara presentasi dengan powerpoint ditambah bantuan leaflet. Peserta juga diberikan bingkisan berupa sampel teh hijau untuk dikonsumsi di rumah. Peserta kegiatan mengikuti jalannya acara dengan baik dan antusias. Evaluasi kegiatan telah dilaksanakan menggunakan metode pretest dan posttest dengan hasil bahwa terdapat peningkatan pengetahuan peserta kegiatan terhadap materi yang telah diberikan.
Efektivitas Antibakteri Kurkumin dan Asam Tanat terhadap Staphylococcus aureus dan Escherichia coli in vitro: Antibacterial Effectiveness of Curcumin and Tannic Acid against Staphylococcus aureus and Escherichia coli in vitro Sardjiman; Rahardjoputro, Rolando; Santoso, Joko; Ernawati; Widyaningrum, Nova Rahma
Indonesian Journal of Pharmacy and Natural Product Vol. 7 No. 01 (2024): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v7i01.2997

Abstract

Some bioactive compounds were isolated and identified from medicinal herbs. Some of bioactive compounds have been used for both health and science. Curcumin and tannic acid are active compounds with antibacterial activity against S. aureus and E. coli. This research aims to determine the antibacterial effectiveness of curcumin and tannic acid against S. aureus and E. coli in vitro. This research is quantitative research with experimental research methods. The antibacterial sensitivity test was carried out in vitro using the Kirby-Bauer disc method. The positive control is the antibiotic ciprofloxacin 50 μg/ml, and the negative control is the DMSO 1% solution. Data analysis used Kruskal-Wallis Test. The research showed that tannic acid 2% provides an average inhibitory zone of 25 mm compared to curcumin (19.67 mm) against S. aureus. Tannic acid 2% provides an average inhibitory zone of 15 mm compared to curcumin (7 mm) against Escherichia coli. Statistical analysis shows a difference in antibacterial effectiveness between tannic acid and curcumin in S. aureus (p-value 0,034) and E. coli (p-value 0,025). The coclusion in this research is tannic acid compounds had stronger bacterial activity against Staphylococcus aureus and Escherichia coli in vitro than curcumin compounds   ABSTRAK Senyawa aktif berhasil diisolasi dari tumbuhan obat sudah banyak ditemui sekarang ini. Beberapa diantaranya telah digunakan untuk kesehatan maupun pengembangan ilmu pengetahuan. Kurkumin dan asam tanat diketahui mempunyai aktivitas antibakteri terhadap S. aureus dan E. coli. Tujuan penelitian ini adalah mengetahui efektivitas antibakteri kurkumin dan asam tanat terhadap S. aureus dan E. coli secara in vitro. Penelitian ini adalah penelitian kuantitatif dengan metode penelitian eksperimental. Uji sensitivitas antibakteri dilakukan secara in vitro dengan metode cakram disc Kirby-Bauer. Kontrol positif yaitu antibiotik siprofloksasin 50 μg/ml dan kontrol negatif larutan DMSO 1%. Analisa data menggunakan uji Kruskal-Wallis. Hasil penelitian menunjukkan asam tanat pada konsentrasi 2% memberikan daya hambat rata – rata 25 mm dibandingkan kurkumin yaitu 19,67 mm terhadap S. aureus. Asam tanat pada konsentrasi 2% memberikan daya hambat rata – rata 15 mm dibandingkan kurkumin yaitu 7 mm terhadap E. coli. Hasil uji statistik menunjukkan bahwa terdapat perbedaan efektivitas antibakteri antara asam tanat dengan kurkumin pada S. aureus (p-value 0,034) dan E. coli (p-value 0,025). Kesimpulan penelitian ini adalah asam tanat mempunyai aktivitas bakteri yang lebih kuat terhadap bakteri S. aureus dan E. coli dibandingkan kurkumin secara in vitro
A STUDY OF DRUG RELATED PROBLEMS IN CHRONIC KIDNEY DISEASE PATIENTS IN HOSPITAL Sholihah, Inayatush; Salindri Pratama, Tiara Dewi; Ikakusumawati, Novita Dhewi; Rahardjoputro, Rolando
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.9348

Abstract

Patients with chronic kidney disease experience decreased kidney function (as an organ of elimination) and receive various drugs, so they are susceptible to Drug Related Problems (DRP). This study aimed to identify the type of potential DRP and analyzed the influence of gender, age, number of drugs, co-morbidities and length of stay on the incidence of DRP in hospitalized chronic kidney disease patients. This study was a cross-sectional study with retrospective data collection. The subjects of the study were chronic kidney disease patients who underwent hospitalization at a hospital in Surakarta at 2016-2021. The incidence of DRP was analyzed descriptively using the PCNE V9.1 algorithm, while the associations between risk factors and the incidence of DRP was analyzed statistically using the Fisher’s Exact Test. Data were obtained from 54 patients whose progress was followed up through medical record. The results showed that 36 patients (66.67%) had DRP while 18 patients (33.33%) did not. In the Problem category there were 22 events while in the Cause category there were 34 events. The results of statistical analysis using the Fisher's Exact Test showed that there were no significant associations between the risk factors (gender, age, number of drugs, number of co-morbidities, length of stay) and the incidence of DRP in hospitalized chronic kidney disease patients.
Cost-Consequence Analysis of Levofloxacin Compared to Ceftriaxone in Community-Acquired Pneumonia of Adult Inpatients at X Hospital Surakarta Rahardjoputro, Rolando; Amrullah, Adhi Wardhana; Santoso, Joko; Saraswati, Hanugrah Ardya Crisdian; Ernawati; Astuti, Hutari Puji; Irdianty, Mellia Silvy; Fitriana, Rufaida Nur
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.89-100

Abstract

Background: Community-acquired pneumonia is still a significant cost-burden disease in healthcare facilities. Pharmacoeconomic analysis using the cost-consequence analysis (CCA) method of ceftriaxone compared to levofloxacin as a first-line empirical antibiotic has never been carried out. Objective: to model the clinical and economic impact of administering ceftriaxone as a first-line empirical antibiotic compared to its comparator levofloxacin for community-acquired pneumonia therapy in hospitalized adult inpatients from the perspective of healthcare facilities. Methods: This research is a retrospective observational study that collects medical records and patient billing data in X Hospital Surakarta from January to December 2022 period. The study was conducted from June to July 2023. Subjects were adult inpatients aged ≥ 18 years with community-acquired pneumonia and were given levofloxacin or ceftriaxone as first-line empiric antibiotics. The data taken included patient profile, antibiotic effectiveness and direct medical costs. Cost-consequence analysis (CCA) was used to compare levofloxacin to ceftriaxone to assess their impact on length of stay, antibiotic effectiveness, and direct medical costs based on a healthcare perspective. Results: The antibiotic effectiveness for levofloxacin was 75.00%, and ceftriaxone was 93.33%. The average length of stay for levofloxacin was 3.39 days, and ceftriaxone was 3.00 days. The total direct medical costs for levofloxacin were IDR 2,056,799, and ceftriaxone was IDR 1,969,627. Conclusion: The administration of ceftriaxone to levofloxacin as a first-line empirical antibiotic for community-acquired pneumonia in hospitalized adult patients had the consequence of increasing antibiotic effectiveness, reducing the length of stay and saving total direct medical costs by IDR 87,172.
Evaluasi Pola Pengobatan Antihipertensi pada Pasien Hipertensi Rawat Jalan di Puskesmas Sumberlawang Sragen Tahun 2023 Elira Dwi Ayu Erlandi; Hanugrah Ardya Crisdian Saraswati; Rolando Rahardjoputro
Jurnal Siti Rufaidah Vol. 2 No. 3 (2024): Agustus : Jurnal Siti Rufaidah
Publisher : PPNI UNIMMAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jasira.v2i3.88

Abstract

Hypertension is a Non-Communicable Disease (NCD) characterized by elevated blood pressure above the normal value of 140/90 mmHg. Evaluation of antihypertensive drug use aims to ensure rational and effective medication use in hypertensive patients. Improper medication use can lead to treatment failure. The objective of this study is to evaluate the pattern of antihypertensive treatment among hypertensive outpatients at the Community Health Center (Puskesmas) of Sumberlawang Sub-District, Sragen in 2023. The research was descriptive observational with a cross-sectional study design. Sample selection used purposive sampling based on inclusion and exclusion criteria. The instrument for this study utilized medical records data of hypertensive outpatients at the Community Health Center (Puskesmas) Sumberlawang, Sragen from January to December 2023. Results from the study involving 100 hypertensive patients showed that the majority were female (78%), aged between 51-61 years (40%), with amlodipine being the most frequently used antihypertensive medication (62%), and Calcium Channel Blockers being the most commonly prescribed class of antihypertensive drugs (60%). Evaluation of antihypertensive treatment patterns among 100 patients revealed percentages indicating appropriate indication (100%), patient suitability (100%), correct drug selection (97%), and correct dosage (97%).