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All Journal Acta Biochimica Indonesiana
Novi Silvia Hardiany
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology

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Identification of cardiac premature senescence markers through GEO database interaction approach Tiwuk Susantiningsih; Ani Retno Prijanti; Novi Silvia Hardiany; Fadilah
Acta Biochimica Indonesiana Vol. 7 No. 1 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.110

Abstract

Background: Cardiomyocytes are cardiac muscle cells where premature senescence can occur. The availability of in silico research regarding premature senescence in cardiomyocytes is still limited. Purpose: This in silico research aims to identify marker of cardiac premature senescence through the GEO database interaction approach. Methods: This research used the GEO database with the GeneCards website approach using four keywords: premature senescence AND cardiovascular AND cardiomyocytes AND p53 followed by Cytoscape 3.9.1 analysis and StringDB analysis. Results: From 1,046 proteins obtained, analyzed by using Cytoscape Tools series 3.9.1 resulted to 100 proteins having the highest score and continued with StringDB analysis with 16 proteins. Conclusion: From the GeneCards, Cytoscape, and StringDB data, analysis of protein interactions in cardiac premature senescence showed that the protein-protein interactions with the highest scores were TP53, CDK2, and PTEN.
Co-Authors Ani Retno Prijanti Fadilah Tiwuk Susantiningsih