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All Journal Majalah Kedokteran Gigi Indonesia Journal of Economics and Management Scienties
Irawan, Catherine Marcia
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Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Library & Information Science Social Sciences

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A potential of Jasminum sambac (L.) Aiton leaf nano-extract as spray treatment of gingivitis-induced Sprague Dawley rats Nuryanti, Archadian; Larasati, Puspa Ayu Aprilia; Almeyda, Alda Risma; Marandof, Monica Agnesia; Irawan, Catherine Marcia
Majalah Kedokteran Gigi Indonesia Vol 9, No 1 (2023): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.69468

Abstract

Gingivitis is the second most common disease that occurs in the oral cavity. The use of chlorhexidine as a gingivitis therapy agent has some side effects such as allergic reactions and bacterial resistance. Jasminum Sambac (L.) Aiton leaf nano-extract contains flavonoids, saponins, and tannins compounds reported to have an influence on wound healing process. The aim of this research was to determine the effect of observation time and concentrations of Jasminum sambac (L.) Aiton leaf nano-extract on the number of neutrophils, macrophages, and angiogenesis in the treatment of gingivitis-induced Sprague Dawley rats. Sixty male Sprague Dawley rats aged 2.5-3 months with body weight of 200-250 g were anesthetized with ketamine HCl (10 mg/kg BW) and xylazine (2 mg/kg BW) then induced using silk ligature 3.0 on the interdental of the mandibular incisor. The rats were divided into five groups and got daily spray using distilled water (negative control), nano-extract at a concentration of 40%, 45%, 50%, and 0.12% chlorhexidine (positive control). The rats were euthanized on the 1st, 3rd, 5th, and 7th days post-treatment. The tissues were processed histologically with HE staining. The number of neutrophils, macrophages, and angiogenesis were counted using a microscope (400x) and OptiLab Viewer® (13x) at five fields of view. The result of the Two Way ANOVA test showed that there were significant effect of concentrations and observation time, and interaction of both observation time and concentrations on the number of neutrophils, macrophages, and angiogenesis (p < 0.05). It can be concluded that observation time and concentrations of Jasminum sambac (L.) Aiton leaf nano-extract affected the number of neutrophils, macrophage, and angiogenesis in the treatment of gingivitis-induced Sprague Dawley rat (p < 0.05).
Pentingnya Transmisi Nilai Founder pada Family Business Bidang Kesehatan Irawan, Catherine Marcia; Padmalia, Metta; Gideon, Andrea
Journal of Economics and Management Scienties Volume 8 No. 3, June 2026 (Accepted)
Publisher : SAFE-Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37034/jems.v8i3.397

Abstract

Family business research generally focuses on succession issues, while the transmission of founder values—particularly in the healthcare context—remains relatively underexplored, despite the intuition that healthcare relies heavily on trust, clinical-patient ethics, and professionalism. Organizational culture serves as a mechanism for institutionalizing founder values, maintaining consistency of service identity, professional quality, and patient trust across generations, and enabling organizational intentions to occur without the founder's direct involvement. This study aims to explore how organizational culture/founder values ​​are constructed, transmitted, and interpreted across generations in a healthcare family business. The study employs a social constructivism paradigm with a qualitative case study approach. Data were collected through semi-structured interviews with the founder, successor, second-born child, and senior manager, and analyzed using open-axial-selective coding and reflexive thematic analysis. The findings identify three core values—compassion, integrity, and excellence—that manifest interconnectedly in the clinical, business, and leadership domains. These values ​​are not mechanically replicated but rather reproduced and reinterpreted according to generational roles and contexts, ultimately becoming institutionalized as organizational culture. This process allows the organization to maintain its service identity, professional quality, and patient trust, even as the founder begins to withdraw from direct involvement.
Co-Authors Almeyda, Alda Risma Andrea Gideon Archadian Nuryanti Larasati, Puspa Ayu Aprilia Marandof, Monica Agnesia Metta Padmalia