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All Journal Jurnal Sehat Indonesia (JUSINDO) Eduvest - Journal of Universal Studies
Aryo Tedjo
Universitas Indonesia
Aerospace Engineering Computer Science & IT Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Prediksi Mekanisme Kerja Whey Protein Sebagai Suplemen Anti-Diabetes dan Anti-Obesitas Berdasarkan Analisis Diffrentially Genes Expressed (DEG) Inflamasi Siti Nurbaya; Aryo Tedjo
Jurnal Sehat Indonesia (JUSINDO) Vol. 6 No. 02 (2024): Jurnal Sehat Indonesia (JUSINDO)
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v6i02.182

Abstract

Obesitas sering dikaitkan dengan inflamasi, yang memicu pelepasan mediator inflamasi dan menurunkan produksi adiponektin. Beberapa teori menyebutkan bahwa peradangan kronis akibat obesitas merupakan mekanisme dominan diabetes tipe 2 (T2D). Penelitian ini melakukan analisis Differentially Genes Expressed (DEG) terkait inflamasi menggunakan basis data Gene Expression Omnibus (GEO) untuk melihat perubahan transkripsi (ekspresi gen) pada hati manusia yang berkontribusi pada akumulasi lipid hati dan resistensi insulin terkait T2D. DEG yang dihasilkan kemudian digunakan untuk melihat apakah whey protein (WP) dapat mempengaruhi DEG tersebut. Konsumsi WP dipercaya dapat menurunkan kelebihan berat badan dan kadar gula darah. Hasil analisis DEG menunjukkan terdapat 22 gen terkait inflamasi  pada liver yang berbeda ekspresinya antara Lean dengan kelompok pasien obesitas tanpa T2D (Obese_noT2D) dan dengan kelompok pasien obesitas dengan T2D yang tidak terkontrol (Obese_T2D-poorly controlled). Berdasarkan  penelitian ini, tidak satu-pun gen-gen tersebut yang dipengaruhi oleh asupan WP. Namun demikian beberapa gen yang diduga berperan dalam inflamasi, obesitas, dan T2D seperti FOXJ1, NLRP1, LGALS2, LIME1, NOTCH3, ARBB2, SIM2, dan TAT berpotensi dipengaruhi oleh asupan WP.
In Silico Study: Metabolite Compounds of Zingiber Officinale Var. Rubrum as Potential E2F2 Inhibitor Agents in Breast Cancer Signaling Pathway Khoirunnisa Purwamita Budiutami; Aryo Tedjo; Fadilah Fadilah; Surya Dwira; Ajeng M. Fajrin
Eduvest - Journal of Universal Studies Vol. 6 No. 1 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i1.52614

Abstract

Breast cancer ranks among the leading causes of death in women, linked to disruptions in signaling pathways regulating cell proliferation and survival, particularly E2F2 gene activity. E2F2 regulation falters when pRB is phosphorylated by Cyclin D–CDK4/6 or Cyclin E–CDK2 complexes, freeing E2F2 to activate cell cycle genes. This study, "In Silico Study: Metabolite Compounds of Zingiber officinale var. rubrum as Potential E2F2 Inhibitor Agents in Breast Cancer Signaling Pathway," assesses red ginger (Zingiber officinale var. rubrum) metabolites as CDK4/CDK6 inhibitors via molecular docking in silico. Target protein structures came from the Protein Data Bank; metabolites were chosen for reported anticancer effects and 3D-modeled. Docking used Molegro Virtual Docker to gauge ligand affinity and interactions at active sites. Results highlighted [12]-shogaol, (E,E)-α-farnesene, and 1-dehydro-[6]-gingerdione as CDK4 inhibitors; azafrin, [8]-shogaol, and [12]-shogaol for CDK6. These exhibit strong binding via hydrogen bonds and hydrophobic interactions at key residues. Red ginger metabolites show promise as CDK4/CDK6 inhibitors for breast cancer therapy, pending in vitro/in vivo validation.
Co-Authors Ajeng M. Fajrin Fadilah Fadilah Khoirunnisa Purwamita Budiutami Siti Nurbaya Surya Dwira