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All Journal ACTA VETERINARIA INDONESIANA Current Biomedicine
Aurellia, Sharon
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Activity of arabica green coffee bean (Coffea arabica) extract as an immunomodulator in mice (Mus musculus) infected with Staphylococcus aureus Aurellia, Sharon; Subangkit, Mawar; Andriyanto, Andriyanto
Current Biomedicine Vol. 2 No. 1 (2024): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.2.1.29-35

Abstract

Arabica green coffee bean is the most widely produced coffee bean in Indonesia. Studies have shown that arabica green coffee beans are rich in polyphenols and antioxidants, stimulating immune cell proliferation. This study investigated the immunomodulatory activity of arabica green coffee beans (Coffea arabica). Thirty mice (Mus musculus) with an average body weight of 30 g were divided into five groups: negative control, positive control, and groups administered arabica green coffee bean powder extract at doses of 0.03, 0.06, and 0.18 mg/30 g BW. It was orally administered once daily for 14 days. On the 15th day, the mice were intraperitoneally injected with non-pathogenic Staphylococcus aureus. After an hour, mice were necropsied for peritoneal fluid collection. Peritoneal fluid was stained with a peripheral blood smear, and the number of macrophages and lymphocytes was observed under a microscope. Data were analyzed using one-way analysis of variance (ANOVA), followed by Tukey’s test. The group administered with 0.18 mg/30 g body weight (BW) dose showed the highest average of macrophage and lymphocytes compared to the negative control group and any other groups. Arabica green coffee bean powder extract was shown to have immunomodulatory activity, with the highest activity observed at a dosage of 0.18 mg/30 g BW.
Effectivity and Safety of Endo-1,4 -xylanase (Xylanase), Endo-1,3(4) beta-glucanase (Beta-glucanase), Endo-1,4 beta-glucanase (Cellulase), and α Amylase as A Growth Promoter in Broiler Chickens Aurellia, Sharon; Fadholly, Amaq
Acta VETERINARIA Indonesiana Vol. 13 No. 1 (2025): Maret 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.1.37-43

Abstract

This study evaluates the effectivity and safety of Endo-1,4 -xylanase (Xylanase), Endo-1,3(4) beta-glucanase (Beta-glucanase), Endo-1,4 beta-glucanase (Cellulase), and α Amylase that packed in Ronozyme-AX ct (MGHSPHYT+) as an alternative to antibiotic growth promoter. A total of 64 chickens were used, divided into four groups, with each group divided into two replicates, 8 chickens per replicate. The groups were divided into treatment group, and groups administered with the different dosage of supplementation, namely 184, 230, and 276 gram/ton feed for 28 days, consecutively. Parameters such as weekly weight gain, final weight, feed conversion ratio (FCR), and carcass weight were observed to determine growth performance. Meanwhile, parameters such as mortality, blood hematology and biochemistry were observed to determine the safety of the supplementation. Based on the results, there was a significant difference on weekly weight gain, particularly in the second week, and in the final weight, with the group administered with 184 gram/ton feed showing the highest result. Meanwhile, other parameters such as FCR and carcass weight did not show any significant difference. This may be due to the enzymes not working directly to increase feed utilization but work with improving nutrient digestibility and utilization in the body. The safety parameters showed that the supplementation was relatively safe as no significant difference was observed in mortality, blood constituents and biochemistry.
The Effect of Endo-1,4-β-xylanase as a Feed Additive on the Growth and Overall Health of Broiler Chickens Fadholly, Amaq; Aurellia, Sharon
Acta VETERINARIA Indonesiana Vol. 13 No. 1 (2025): Maret 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.1.16-21

Abstract

Enzyme has been used widely as a feed additive to complement poultry needs of nutrition. Endo-1,4 beta-xylanase as its main component, which is effective in digesting non-starch polysaccharides (NSPs), hence improving the digestive system. This research aims to observe the efficacy of Endo-1,4-β-xylanase as a growth promotor and its safety. A total of 96 chickens were used in this research, divided into four groups. Administration depending on each group was conducted for 28 days, consecutively. Growth parameters that were observed includes body weight gain and feed conversion ratio, meanwhile for safety assessment, the parameters used were mortality rate, and blood profile. Based on the results, the enzyme was proven to enhance growth performance through the increased body weight gain and final weight. This is due to the enzyme’s mechanism which improves nutrient utilization. Based on the safety assessment, Endo-1,4-β-xylanase was also proven to be safe, not causing any inflammation responses in the body nor organ damage based on the blood assessment.
Co-Authors Amaq Fadholly Andriyanto Andriyanto Subangkit, Mawar