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All Journal Jurnal Ilmu Kesehatan dan Gizi Mutiara: Jurnal Penelitian dan Karya Ilmiah
Basli Muhammad
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Religion Humanities Computer Science & IT Electrical & Electronics Engineering Health Professions Languange, Linguistic, Communication & Media Other

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Perdarahan Intraserebral Basli Muhammad; Jihan Nabila
Jurnal Ilmu Kesehatan dan Gizi Vol. 1 No. 4 (2023): Oktober: Jurnal Imu Kesehatan dan Gizi
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikg.v1i4.1677

Abstract

Haemorrhagic stroke, or also known as spontaneous intracerebral haemorrhage (PIS), is one of the pathological types of stroke caused by intracerebral blood vessels. This condition causes neurological symptoms that occur suddenly and often followed by symptoms due to the spatial effects or increased intracranial pressure (TIK). Generally speaking, the number of strokes is increasing, according to (RISKESDAS) the Ministry of Health of the Republic of Indonesia there is an increase in stroke prevalence from 8.3 (2007) to 12.2 (2013) per 1000 people. In PIS, primary injury occurs: neuron and glia damage mechanically followed by deformation, neurotransmitter release, mitochondrial dysfunction and cell membrane depolarization. Secondary injuries due to haemoglobin breakdown and coagulation factors especially thrombin. The product will activate microglia so it produces toxic substances such as reactive oxygen species (ROS), matrix metalloproteinase (MMP), cyclooxygenase-2, prostaglandin, heme oxygenase-1 (HO-1), complement factor, tumour necrotizing factor α (TNF α), and interleukin 1β causing network injury. In addition to injury, there's also a replacement of dead cells through the neurogenesis process, which is the growth of neuronal stem cells in the subventricular and hippocampus areas. The number of hemorrhagic strokes in Asia is higher than in the West. This could be due to the high incidence of hypertension in the Asian population.
Guillain-Barré syndrome Silvi Afifah; Basli Muhammad
Mutiara : Jurnal Penelitian dan Karya Ilmiah Vol. 3 No. 3 (2025): Juni : Mutiara : Jurnal Penelitian dan Karya Ilmiah
Publisher : STAI YPIQ BAUBAU, SULAWESI TENGGARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59059/mutiara.v3i3.2334

Abstract

Guillain-Barré Syndrome (GBS) is a serious but rare post-infectious immune-mediated neuropathy. This disease is caused by autoimmune damage to nerves in the peripheral nervous system causing symptoms such as numbness, tingling, and weakness that can progress to paralysis. The incidence of GBS is 0.42 cases per 100,000 people. The highest incidence occurs in adolescents and the elderly at the age of 50 years. While in children, cases with Acute Flaccid Paralysis occur in 25.9% - 50% of children. So the incidence of GBS in children is 0.34 cases per 100,000 children. If it attacks children, they will experience progressive motor development disorders, and can even cause death. The most effective therapy is generally intravenous immunoglobulin (IVIG). In general, the outcome of GBS is more favorable in children than in adults; however, the recovery period is long, often weeks to months.
Co-Authors Jihan Nabila Silvi Afifah