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All Journal Dentika Dental Journal
Anggun, Gheta
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Dentistry

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Efficacy of non-surgical therapy on IL-6 levels in patients with chronic periodontitis: A systematic review Winiati, Endang; Alwiyansyah, Annisa Nurrahma; Sebastian, James; Owen, Kevin; Anggun, Gheta
Dentika: Dental Journal Vol. 27 No. 1 (2024): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v27i1.15272

Abstract

Chronic periodontitis-affected tissues have an increased production of pro-inflammatory cytokines relative to anti-inflammatory counterparts, including IL-6. Therefore, this systematic review aimed to synthesize and appraise the available literature to provide a comprehensive analysis of the efficacy of non-surgical therapy, specifically focusing on the therapeutic effect of IL-6 in patients with chronic periodontitis. This review focused on seven studies including 308 patients with moderate to severe chronic periodontitis across five different countries. The RoB assessment showed a moderate to low risk of bias studies. Moreover, the studies found a statistically significant decrease in IL-6 levels in patients after receiving non-surgical therapy. There were statistically significant alterations in periodontal indices and IL-6 levels over time, which showed the efficacy of non-surgical treatment based on various literature. Hence, decreasing IL-6 could serve as a therapeutic indicator of inflammatory response.
Co-Authors Alwiyansyah, Annisa Nurrahma Endang Winiati, Endang Owen, Kevin Sebastian, James