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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Hang Tuah Medical Journal
I GEDE AGUS RIO SAPUTRA
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Perbedaan Sebaran Jumlah Pembuluh Darah pada Selaput Ketuban Kasus Ketuban Pecah Dini Dan Tidak Ketuban Pecah Dini: I GEDE AGUS RIO SAPUTRA; KETUT EDY SUDIARTA; MITA HEDIYANTINI
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.135

Abstract

ABSTRAK Latar belakang: World Health Organization (WHO) menyatakan bahwa setiap tahunnya wanita yang bersalin meninggal dunia mencapai lebih dari 500.000 orang. Di Indonesia angka kematian ibu dan angka kematian bayi masih tinggi dan merupakan masalah yang menjadi prioritas dibidang kesehatan. Penyebab utama kematian bayi baru lahir atau neonatal di dunia antara lain persalinan prematur 29%, sepsis dan pneumonia 25% dan 23% asfiksia dan trauma. Secara garis besar kejadian persalinan prematur 50% terjadi spontan, 70% akibat ketuban pecah dini, dan 20% dilahirkan atas indikasi ibu dan janin. Ketuban pecah dini (KPD) merupakan keadaan pecahnya selaput ketuban sebelum terjadinya tanda-tanda persalinan. Prevalensi KPD berkisar 3-18% dari seluruh kehamilan. Metode: Metode penelitian dipilih secara studi potong lintang dari selaput janin pada pasien ketuban pecah dini dan tidak ketuban pecah dini. Data yang diperoleh dianalisis secara univariat, dan bivariat. Sedangkan untuk mengetahui ada tidaknya perbedaan digunakan uji chi square. Ada perbedaan jika p-value < 0,05 dan tidak ada perbedaan jika p-value > 0,05. Hasil: Uji Chi-Square antara hasil pemeriksaan histopatologi pembuluh darah dari selaput janin ketuban pecah dini dan tidak ketuban pecah dini menunjukkan kekuatan perbedaan dari hasil pemeriksaan patologi anatomi dari selaput janin ketuban pecah dini dan tidak ketuban pecah dini sebesar 0.001 < 0,05 Kesimpulan: Perbedaan antara hasil pemeriksaan patologi anatomi pembuluh darah dari selaput janin ketuban pecah dini dan tidak ketuban pecah dini adalah signifikan Kata Kunci: Ketuban Pecah Dini, Patologi Anatomi, Pembuluh Darah
Impact of Tocolytic Therapy on Cardiovascular Outcomes in Preterm Labor: A Systematic Review and Meta-Analysis Ni Putu Ika Regiana Maharani; I Gede Agus Rio Saputra; Anak Agung Ngurah Gede Anggra Pramana; I Putu Gede Budiana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1283

Abstract

Background: Preterm labor is a significant cause of neonatal morbidity and mortality, and tocolytic therapy is often used to delay delivery and improve neonatal outcomes. However, tocolytic drugs can have adverse cardiovascular effects, including an increased risk of atrial fibrillation (AF). This meta-analysis aims to evaluate the impact of tocolytic therapy on cardiovascular outcomes in preterm labor, focusing on the risk of AF. Methods: A systematic literature review was conducted following PRISMA guidelines. Relevant studies published between 2013 and 2024 were identified through PubMed, Scopus, ScienceDirect, and Cochrane Library. Studies evaluating the cardiovascular effects of tocolytic therapy in preterm labor were included. The primary outcome was the incidence of AF. Secondary outcomes included other cardiovascular adverse events. Results: Ten studies met the inclusion criteria, comprising 550 pregnant women receiving tocolytic therapy. Tocolytic therapy was associated with a significantly increased risk of AF compared to no tocolytic therapy (mean difference 0.2, 95% CI 0.10-0.30). Nifedipine and ritodrine had a higher risk of AF compared to atosiban. The risk of AF was also higher in patients with pre-existing cardiovascular diseases. Conclusion: Tocolytic therapy, particularly with nifedipine and ritodrine, increases the risk of AF in preterm labor. Atosiban appears to be a safer option for patients with cardiovascular risk factors. Careful consideration of the potential cardiovascular risks and benefits is crucial when making tocolytic therapy decisions.
Impact of Tocolytic Therapy on Cardiovascular Outcomes in Preterm Labor: A Systematic Review and Meta-Analysis Ni Putu Ika Regiana Maharani; I Gede Agus Rio Saputra; Anak Agung Ngurah Gede Anggra Pramana; I Putu Gede Budiana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1283

Abstract

Background: Preterm labor is a significant cause of neonatal morbidity and mortality, and tocolytic therapy is often used to delay delivery and improve neonatal outcomes. However, tocolytic drugs can have adverse cardiovascular effects, including an increased risk of atrial fibrillation (AF). This meta-analysis aims to evaluate the impact of tocolytic therapy on cardiovascular outcomes in preterm labor, focusing on the risk of AF. Methods: A systematic literature review was conducted following PRISMA guidelines. Relevant studies published between 2013 and 2024 were identified through PubMed, Scopus, ScienceDirect, and Cochrane Library. Studies evaluating the cardiovascular effects of tocolytic therapy in preterm labor were included. The primary outcome was the incidence of AF. Secondary outcomes included other cardiovascular adverse events. Results: Ten studies met the inclusion criteria, comprising 550 pregnant women receiving tocolytic therapy. Tocolytic therapy was associated with a significantly increased risk of AF compared to no tocolytic therapy (mean difference 0.2, 95% CI 0.10-0.30). Nifedipine and ritodrine had a higher risk of AF compared to atosiban. The risk of AF was also higher in patients with pre-existing cardiovascular diseases. Conclusion: Tocolytic therapy, particularly with nifedipine and ritodrine, increases the risk of AF in preterm labor. Atosiban appears to be a safer option for patients with cardiovascular risk factors. Careful consideration of the potential cardiovascular risks and benefits is crucial when making tocolytic therapy decisions.
Co-Authors Anak Agung Ngurah Gede Anggra Pramana I Putu Gede Budiana Ketut Edy Sudiarta MITA HEDIYANTINI Ni Putu Ika Regiana Maharani