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All Journal The Indonesian Biomedical Journal Oceana Biomedicina Journal Indian Journal of Forensic Medicine & Toxicology Hang Tuah Medical Journal
Ketut Edy Sudiarta
Universitas Hang Tuah
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Successful Conservative Management of Premature Rupture Membranes of Twin Pregnancy with one Fetus Papyraceus Ketut Edy Sudiarta
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14776

Abstract

Fetus papyraceus is a rare obstetrics complication and is characterized by the death of one or more fetuses inthe early gestation period, and the other fetus continues to develop. This report describes a twin pregnancywith one fetus papyraceus and both undergone premature membrane rupture. We reported a 25-year-oldwoman unbooking patient admitted to the Pusura hospital with a complaint of amniotic fluid leaking fromthe vagina after a traffic accident. The patient is a woman with a history of G2P1A0 at 22-week gestationwith twin pregnancies (monochorionic diamniotic twin pregnancy). There was one live fetus with cephalicpresentation and the other one was papyraceus. Conservative management with a corticosteroid regimento complete the lung maturation was done. At 32-week gestation, the patient was admitted back withspontaneous rupture membranes and the live fetus was seen in lie presentation. She underwent a caesariansection and a premature life female baby was delivered with 1800g of weigh, APGAR score of 7 at 1 minuteand 8 at 5 minutes. The fetus papyraceus was weighed 100g. Both the mother and the baby were dischargedhome in good condition. Fetus papyraceus is a rare condition that describes intrauterine fetal demise in earlypregnancies. It can occur in both single or multiple gestation pregnancies. This case report reported case is apremature rupture of the membranes caused by a traffic accident. A life baby weighing 1800g was deliveredand 100g of weigh of fetus papyraceus in a caesarian section. This case is a diamniotic – monochorionicplacenta. Finally, the healthy baby was discharged 18 days after delivery.
Karakteristik Partus Prematurus Imminens di Rspal Dr Ramelan Surabaya Periode Juni 2019 – Juni 2020 MALIKU NURROCHMAN WIDANDI; MITA HERDIYANTINI; KETUT EDY SUDIARTA
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.141

Abstract

Background: The child mortality rate in the world and in Indonesia in particular is still high. Based on WHO data, Indonesia is in the top 10 countries with a total of 675,700 cases of premature birth. Premature labor is often preceded by signs of labor called Threatened Preterm Labor. Threatened Preterm Labor is the occurrence of a threat of labor in the form of uterine contractions and/or other signs of labor at gestational age between > 20 - < 37 weeks. If it does not get adequate treatment, it is often followed by premature birth. Prematurity increases the rate of cesarean delivery and increases child mortality. This study aims to determine the characteristics of pregnant women with Threatened Preterm Labor at RSPAL Dr. Ramelan Surabaya. Methods: This research is a descriptive study using purposive sampling technique. The research sample used Threatened Preterm Labor cases recorded in the medical records of RSPAL Dr. Ramelan Surabaya. Results: The results showed that 50 cases of Threatened Preterm Labor. Most of them occurred at the age of 20 - 35 years as many as 39 (78%), with a high school education level of 31 (62%), as many as 26 patients (52%) worked. Based on parity, most occurred in primiparous as many as 19 cases (38%). Based on ANC visits, the majority of patients who did not perform ANC were 43 patients (86%). Most of them had normal blood pressure as many as 37 patients (74%), 30 patients (60%) had low hemoglobin levels / anemia, and 29 patients (58%) had normal leukocyte levels. Most previous pregnancy history in normal pregnancy was 28 cases (56%). A total of 31 patients (62%) had complications in pregnancy. The success of tocolytic therapy was 34 cases (68%). Conclusion: Eighty-six percent of PPI patients admitted to RSPAL never had ANC, 60% of the samples were included in the anemia category, and 62% were motivated by complications of this pregnancy including premature rupture of membranes (PROM), preeclampsia, gemelli, gestational diabetes, infection, anemia, and polyhydramnios. Suggestion: more intensive public health education is needed, especially for pregnant women.
High NF-κB and RAGE Expression in Fetal Membrane of Premature Rupture of Membrane (PROM) Subject I Ketut Edy Sudiarta; Monicha Zalzabilla Aldinasyah; Cindy Jennilyn Candra; Supriyono Supriyono; Annisa Ullya Rasyida
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.1859

Abstract

BACKGROUND: Premature Rupture of Membranes (PROM) is significantly linked to the infections-related maternal deaths. In the inflammatory process, the influencing stressor will stimulate the activation of Nuclear Factor Kappa B (NF-κB) and Receptor of Advanced Gyclation End product (RAGE). Yet up to date, the expression of NF-κB and RAGE in pregnant women with PROM are still rarely studied. Therefore, this study aimed to observe the differences of NF-κB and RAGE expression from PROM and non-PROM subjects.METHODS: This was a cross-sectional study involving 20 PROM subjects and 20 non-PROM subjects with infections and complications. Samples from the fetal membrane tissue of subjects were obtained and put into paraffin block preparation for the determination of NF-κB and RAGE expression. The detection of NF-κB and RAGE expression was conducted using immunohistochemical staining and observed under an upright light microscope. The expressions were later calculated using ImageJ software. RESULTS: Both NF-κB and RAGE expression were found to be higher in PROM subjects compare to the non-PROM subjects. The median of NF-κB in PROM and non-PROM subjects were 32.47±1.22 and 5.59±1.09, respectively (p=0.000). While the median of RAGE in PROM subjects was 53.58±3.46, and in non-PROM subjects was 11.64±2.49 (p=0.013).CONCLUSION: There is significant difference between NF-κB and RAGE expression in fetal membranes of PROM and non-PROM subjects. Therefore, the increased of NF-κB and RAGE expression can be used as a potential marker to detect complication of PROM.KEYWORDS: premature ruptures of membrane, non-premature ruptures of membrane, expression of NF-κB 
Hubungan Usia Dengan Kejadian Prolaps Uteri di Departemen Obstetri dan Ginekologi RSPAL dr. Ramelan surabaya KETUT EDY SUDIARTA; MOCHAMAD ALVIRIO NEDYA RIZKA; MUHAMMAD RIZAL; NANDA ABIGAIL; RONALD PRATAMA
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract

ABSTRACT BACKGROUND: Uterine prolapse is the descent of the cervix, uterus, and both adnexa from their normal position into the vagina. In general, the incidence of pelvic organ prolapse is 41-50% in women aged over 40 years and will increase with increasing life expectancy, and uterine prolaps is the second most common after cystourethrocele. The incidence of uterine prolapse patients is not known with certainty. Some studies report the incidence of uterine prolapse in the elderly, but there are also studies that report mostly at the age of 20-35 years. Therefore, we conducted a study to determine the relationship between age and uterine prolapse. METHODS: The study used a cross-sectional approach to determine the relationship between age and uterine prolapse in the Obstetrics-Gynecology ward at the Naval Center Hospital Dr. Ramelan Surabaya for the period 2019 to 2021. The data is presented in the form of tables and statistical tests using Q2-Square. CONCLUSION: In the period 2019-2021, there were 1797 cases of gynecological patients in the gynecology inpatient room and 63 cases (3.5%) of them were uterine prolapse. The highest incidence was in the age group 60-64 years with 27.0% (n=17) with distribution based on the level of uterine prolapse the most were grade 3-4 with n = 69.8% (n=44) and grade 1-2 prolapse with 30.2% (n=19). The youngest age is 35 years old and the oldest is 79 years old. Treatment of 63 cases of uterine prolapse 38 cases (60.3%) underwent surgery and 19 cases (39,7%) 9.7%) Keyword: uterine prolapse, pelvic organ, pelvic surgery, management.
PREVALENSI DAN KARAKTERISTIK PERDARAHAN ANTEPARTUM DI RUANG RAWAT INAP OBSTETRI DAN GINEKOLOGI DI RSPAL DR. RAMELAN SURABAYA I Ketut Edy Sudiarta
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.93

Abstract

Background: Bleeding in obstetrics is one of the main causes of maternal mortality. Based on the 2017 World Bank report, in 1 day there are 4 mothers in Indonesia who die due to childbirth. One of the main causes of maternal mortality is antepartum bleeding, as well as preeclampsia and infection. The incidence and characteristics of antepartum bleeding cases are not known with certainty. In this study, we wanted to know the characteristics and prevalence of antepartum bleeding at the Obstetrics and Gynecology Laboratory, RSPAL Surabaya. Methods: A descriptive retrospective study that used a cross-sectional approach to determine the prevalence and characteristics of antepartum bleeding in the Obstetrics-Gynecology Laboratory of the Naval Center Hospital, Dr. Ramelan Surabaya for the period 2019 to 2021. Results and Conclusions: The prevalence of antepartum bleeding in the Obstetrics and Gynecology laboratory during the period January 2019 – December 2021 was 29.9% (91 out of 304 deliveries), with the highest age group being 30-34 years as many as 31 people (34.1%), parity ( P2) mostly 34 patients (37.4%). Based on gestational age, 50 people (54.9%) gestational age <37 weeks, 51 cases (56%) placenta previa and 39 cases (42.8%) placenta accreta/percreta. Case management, 81 cases (89%) were terminated via sesarean section.
Perbedaan Sebaran Jumlah Pembuluh Darah pada Selaput Ketuban Kasus Ketuban Pecah Dini Dan Tidak Ketuban Pecah Dini: I GEDE AGUS RIO SAPUTRA; KETUT EDY SUDIARTA; MITA HEDIYANTINI
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.135

Abstract

ABSTRAK Latar belakang: World Health Organization (WHO) menyatakan bahwa setiap tahunnya wanita yang bersalin meninggal dunia mencapai lebih dari 500.000 orang. Di Indonesia angka kematian ibu dan angka kematian bayi masih tinggi dan merupakan masalah yang menjadi prioritas dibidang kesehatan. Penyebab utama kematian bayi baru lahir atau neonatal di dunia antara lain persalinan prematur 29%, sepsis dan pneumonia 25% dan 23% asfiksia dan trauma. Secara garis besar kejadian persalinan prematur 50% terjadi spontan, 70% akibat ketuban pecah dini, dan 20% dilahirkan atas indikasi ibu dan janin. Ketuban pecah dini (KPD) merupakan keadaan pecahnya selaput ketuban sebelum terjadinya tanda-tanda persalinan. Prevalensi KPD berkisar 3-18% dari seluruh kehamilan. Metode: Metode penelitian dipilih secara studi potong lintang dari selaput janin pada pasien ketuban pecah dini dan tidak ketuban pecah dini. Data yang diperoleh dianalisis secara univariat, dan bivariat. Sedangkan untuk mengetahui ada tidaknya perbedaan digunakan uji chi square. Ada perbedaan jika p-value < 0,05 dan tidak ada perbedaan jika p-value > 0,05. Hasil: Uji Chi-Square antara hasil pemeriksaan histopatologi pembuluh darah dari selaput janin ketuban pecah dini dan tidak ketuban pecah dini menunjukkan kekuatan perbedaan dari hasil pemeriksaan patologi anatomi dari selaput janin ketuban pecah dini dan tidak ketuban pecah dini sebesar 0.001 < 0,05 Kesimpulan: Perbedaan antara hasil pemeriksaan patologi anatomi pembuluh darah dari selaput janin ketuban pecah dini dan tidak ketuban pecah dini adalah signifikan Kata Kunci: Ketuban Pecah Dini, Patologi Anatomi, Pembuluh Darah
Pengaruh Terapi Oksigen Hiperbarik Terhadap Kadar Enzim Katalase Jaringan Otak Tikus Model Alkohol Kronis VIRA AULIA KUSUMA WARDANI; NI KOMANG SRI DEWI UNTARI; KETUT EDY SUDIARTA; VERNA BIUTIFASARI
Hang Tuah Medical Journal Vol 21 No 2 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i2.362

Abstract

Latar belakang: Penyalahgunaan alkohol merupakan salah satu permasalahan serius setelah penyalahgunaan zat dan obat terlarang. Sebanyak 3,3 juta orang meninggal di dunia akibat penggunaan alkohol pada tahun 2018 dan bertanggung jawab atas 5,1% beban penyakit global. Penyalahgunaan alkohol dapat meningkatkan produksi reactive oxygen species (ROS). ROS menimbulkan dampak negatif terhadap serebelum yang berakibat pada penurunan kadar enzim katalase. Winsgoal tidak hanya menyediakan kemudahan deposit qris, tetapi juga tersedia deposit idn slot pulsa tanpa potongan, e-wallet dan transfer bank yang tidak kalah menarik. Terapi oksigen hiperbarik (TOHB) dapat menurunkan produksi ROS dan berpengaruh terhadap kadar enzim katalase jaringan otak. Tujuan: Membuktikan pengaruh terapi oksigen hiperbarik terhadap kadar enzim katalase jaringan otak hewan coba model alkohol kronis Metode: Tikus putih galur wistar diinduksi dengan alkohol 20% 4,5ml/kgBB setiap hari selama 6 minggu untuk mendapatkan model alkohol kronis. Penelitian ini menggunakan tiga kelompok yaitu kelompok kontrol yang tidak diinduksi (K0), kelompok perlakuan yang diinduksi alkohol tanpa TOHB (K1), kelompok intervensi yang diinduksi alkohol dan TOHB (K2). Hasil: Pengukuran kadar katalase didapatkan rerata dan standar deviasi sebesar K0 (877,74 ± 69,54), K1 (617,8 ± 245,32), dan K2 (952,85 ± 47,40); Uji statistik MWU pada kadar katalase mengalami perbedaan yang signifikan di tiap kelompok (p < 0,05). Kesimpulan: Terapi oksigen hiperbarik terbukti berpengaruh terhadap kadar enzim katalase pada hewan coba model alkohol kronis         
Co-Authors ANNISA ULLYA RASYIDA Biutifasari, Verna Cindy Jennilyn Candra I GEDE AGUS RIO SAPUTRA MALIKU NURROCHMAN WIDANDI MITA HEDIYANTINI Mita Herdiyantini MOCHAMAD ALVIRIO NEDYA RIZKA Monicha Zalzabilla Aldinasyah MUHAMMAD RIZAL NANDA ABIGAIL NI KOMANG SRI DEWI UNTARI Ronald Pratama Adiwinoto Supriyono Supriyono VIRA AULIA KUSUMA WARDANI