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All Journal Jurnal Klinik dan Riset Kesehatan Indonesian Journal of Biomedicine and Clinical Sciences
Mumtaza, Hilya Itsnain
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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SEBUAH LAPORAN KASUS Sindrom Nefrotik pada Pasien Pengguna Obat Antiinflamasi Non Steroid (OAINS) pada Dewasa: sebuah Laporan Kasus Mumtaza, Hilya Itsnain; Rochmah, Izzah
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.8

Abstract

Background: Non-steroidal antiinflammatory drugs (NSAID) is a common drug with an antiinflammation and an analgesic effect which consumed widely among people. On the other hand, NSAID also have some adverse effects including nefrotic syndrome (NS). Case Presentation: A man, 20 years old, came with general body swelling. The swelling appeared gradually accompanied by shortness of breath as the body swelling was spread. The patient has a history of frequently consuming pain reliver medications which he bought over the counter, 3-4 times/week since 1 year ago. The patient was diagnosed with nephrotic syndrome. We stop the OAINS and administer some medications, such as, intravenous steroid, oral ARBs, and oral anticoagulant therapy. Patients responded well to the therapy given marked by reduced edema and improved kidney function. Discussion: NS is glomerular syndrome consists of massive proteinuria, hypoalbuminemia, peripheral oedema, and/or hyperlipidemia. The etiology of NS divided into 2 group : primary NS and secondary NS. The primary NS such as minimal change disease glomerulonephritis, membranous nephropathy, focal segmental glomerulonephritis, and IgA nephropathy. In the other hand, secondary SN can be caused by NSAID toxicity, infection, metabolic dysfunction, and autoimmune disease. Conclusion: In this case report, a male, 20 years old is diagnosed with NS and had medical history of being long term NSAID’s user who responded well after given steroid therapy. In order to find the definite etiology of SN, it need adjunct examination such as renal biopsy. Moreover, medical practitioner should do the holistic and comprehensive anamnesis and physical examination associated with the risk of NS.
Managing diagnostic problem of syphilis manifested as chronic colitis and enteropathic arthritis in a 29 yo male: a case report Auliya, Kamila; Nugroho, Cahyo Wibisono; Mumtaza, Hilya Itsnain
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.17895

Abstract

Syphilis is a chronic sexually transmitted infection caused by Gram-negative bacterium, Treponema pallidum, known for its ability to mimic other diseases, leading to misdiagnosis and delayed treatment. We present a case of a 29 yo male with recurrent acute diarrhea, accompanied by fever, nausea, vomiting, prolonged mouth ulcers, and weight loss for the last three months. He was hospitalized multiple times due to the same recurrent problems. He was initially suspected for immunodeficiency diseases and was screened for HIV and hepatitis B, but both results came out negative. The patient was then suspected with malignancy of the gastrointestinal tract and underwent several examinations including; hematology workup, abdominal X-ray, gastroduodenoscopy, colonoscopy and biopsy. However, the result of all abdominal X-ray, biopsy and colonoscopy ruled out malignancy. The examinations discovered intraluminal ileocecal mass that is consist of lymphocytic cells, therefore the patient was diagnosed with chronic colitis and ileitis. The patient went to the clinic as scheduled with a new chief complain of other symptoms; painful spine and hip join movement, which added to his new diagnose of enterophatic arthritis and he was hospitalized for further diagnosis. During hospitalization, the patient was screened for another venereal disease i.e. syphilis, due to the everchanging symptomatology. He was being screened with VDRL, and later TPHA test. This case encompasses the complexity and challenges of diagnostic workup in non-suggestive findings of the disease syphilis as the Great Imitator.
SEBUAH LAPORAN KASUS Sindrom Nefrotik pada Pasien Pengguna Obat Antiinflamasi Non Steroid (OAINS) pada Dewasa: sebuah Laporan Kasus Mumtaza, Hilya Itsnain; Rochmah, Izzah
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.8

Abstract

Background: Non-steroidal antiinflammatory drugs (NSAID) is a common drug with an antiinflammation and an analgesic effect which consumed widely among people. On the other hand, NSAID also have some adverse effects including nefrotic syndrome (NS). Case Presentation: A man, 20 years old, came with general body swelling. The swelling appeared gradually accompanied by shortness of breath as the body swelling was spread. The patient has a history of frequently consuming pain reliver medications which he bought over the counter, 3-4 times/week since 1 year ago. The patient was diagnosed with nephrotic syndrome. We stop the OAINS and administer some medications, such as, intravenous steroid, oral ARBs, and oral anticoagulant therapy. Patients responded well to the therapy given marked by reduced edema and improved kidney function. Discussion: NS is glomerular syndrome consists of massive proteinuria, hypoalbuminemia, peripheral oedema, and/or hyperlipidemia. The etiology of NS divided into 2 group : primary NS and secondary NS. The primary NS such as minimal change disease glomerulonephritis, membranous nephropathy, focal segmental glomerulonephritis, and IgA nephropathy. In the other hand, secondary SN can be caused by NSAID toxicity, infection, metabolic dysfunction, and autoimmune disease. Conclusion: In this case report, a male, 20 years old is diagnosed with NS and had medical history of being long term NSAID’s user who responded well after given steroid therapy. In order to find the definite etiology of SN, it need adjunct examination such as renal biopsy. Moreover, medical practitioner should do the holistic and comprehensive anamnesis and physical examination associated with the risk of NS.
Co-Authors Auliya, Kamila Cahyo Wibisono Nugroho Rochmah, Izzah