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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indonesian Journal of Biomedicine and Clinical Sciences Jurnal Sains dan Kesehatan
Cahyo Wibisono Nugroho
Departement Of Internal Medicine, Airlangga University Hospital, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Anthropometry-based Body Fat Percentage Predicts High hs-CRP in Chronic Kidney Disease Patients Mochammad Thaha; Maulana Antiyan Empitu; Ika Nindya Kadariswantiningsih; Cahyo Wibisono Nugroho; Nurina Hasanatuludhhiyah; Haerani Rasyid; Zaky El Hakim; Maulana Muhtadin Suryansyah; Rieza Rizqi Alda; Mohammad Yusuf Alsagaff; Mochammad Amin; Djoko Santoso; Yusuke Suzuki
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.397

Abstract

BACKGROUND: Obesity is an important cardiovascular risk factor and associated with low grade inflammation in chronic kidney disease (CKD) patients. This study aims to assess the association between body fat with serum high sensitivity C-reactive protein (hs-CRP) level in CKD patients.METHODS: A cross-sectional study was performed in 71 CKD patients. Anthropometric measurements included body weight, height, body mass index (BMI), body fat percentage (BFP), skinfold thickness (SKF) of triceps and biceps were performed by trained physician. BFP was calculated using Kwok’s Formula and hs-CRP was measured by Particle enhanced Turbidimetry.RESULTS: The averaged BMI of our subjects was 25.8±4.4. There was no significant difference in BMI between pre-dialysis and hemodialysis CKD patients. Positive correlation was found between BFP and hs-CRP (r=0.266; p<0.05), while there was no significant correlation between BMI and hs-CRP.CONCLUSION: Body fat percentage was associated with hs-CRP. Hence, it will be more beneficial to assess nutritional status in CKD using BFP rather than BMI alone since it was demonstrated to correlate with hs-CRP in our studyKEYWORDS: CKD, obesity, inflammation, body fat, hs-CRP
Could Complete Blood Count Parameters and Non-fasting Cholesterol Profile Describe Inflammation and Oxidative Stress in Chronic Kidney Disease? Ika Nindya Kadariswantiningsih; Mochammad Thaha; Cahyo Wibisono Nugroho; Berliana Hamidah; Haerani Rasyid; Zaky El Hakim; Maulana Muhtadin Suryansyah; Mohammad Yusuf Alsagaff; Djoko Santoso; Maulana Antiyan Empitu; Yusuke Suzuki
The Indonesian Biomedical Journal Vol 10, No 3 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i3.451

Abstract

BACKGROUND: Establishment of inexpensive clinical laboratory tests to evaluate inflammation and oxidative stress is urgently needed in the limited resources settings. This study aims to investigate the potential of complete blood count (CBC) parameters and non-fasting cholesterol profile parameters to describe inflammation and oxidative stress in chronic kidney disease (CKD) patients.METHODS: Measurement of CBC, non-fasting cholesterol profile, high sensitivity C-reactive protein (hs-CRP) and malondialdehyde (MDA) were performed in 71 CKD patients grouped into hemodialysis (HD) and non-hemodialysis (non-HD). Correlation analysis were performed to assess the potential of CBC and cholesterol profile to describe the level of hs-CRP and MDA.RESULTS: In the HD group, total cholesterol was moderately associated with hs-CRP while total cholesterol/HDL-C ratio, monocyte/HDL-C ratio, monocyte/LDL-C ratio, neutrophil/HDL-C ratio, neutrophil/LDL-C ratio, platelet/HDL-C ratio and platelet/LDL-C ratio were strongly associated with hs-CRP. In the non-HD group,only neutrophil/total cholesterol ratio and platelet/total cholesterol ratio that were associated with hs-CRP. Total cholesterol, monocyte/LDL-C ratio, neutrophil/LDL-C ratio and platelet/LDL-C ratio were moderately associated with MDA while total cholesterol/HDL-C ratio, monocyte/HDL-C ratio, neutrophil/HDL-C ratio and platelet/HDL-C ratio were strongly associated respectively with MDA in HD group. In the non-HD group, total cholesterol/HDL-C ratio, neutrophil/HDL-C ratio and platelet/HDL-C ratio were moderately associated with MDA in non-HD group while monocyte/HDL-C ratio was weakly associated with MDA.CONCLUSION: Some CBC parameters and non-fasting cholesterol profile such as cholesterol/HDL-C, monocyte/HDL-C, neutrophil/HDL-C and platelet/HDL-C ratio showed a potential to describe the inflammation and stress oxidative markers, given some strong associations with the level of hs-CRP and MDA. Further study is needed to assess whether this parameter represent long-term prognostic value among CKD patients.KEYWORDS: inflammation, oxidative stress, CRP, MDA, TAC, 8-OHdG, CBC, cholesterol
Determiner of Poor Sleep Quality in Chronic Kidney Disease Patients Links to Elevated Diastolic Blood Pressure, hs-CRP, and Blood-count-based Inflammatory Predictors Maulana Antiyan Empitu; Ika Nindya Kadariswantiningsih; Mochammad Thaha; Cahyo Wibisono Nugroho; Eka Arum Cahyaning Putri; Zaky El Hakim; Maulana Muhtadin Suryansyah; Rieza Rizqi Alda; Mohammad Yusuf Alsagaff; Mochammad Amin; Djoko Santoso; Yusuke Suzuki
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.452

Abstract

BACKGROUND: Sleep deprivation is strongly associated with cardiovascular disease (CVD) via sympathetic overstimulation and systemic inflammation in general population. However, the significance of poor sleep quality in chronic kidney disease (CKD) is still underexplored.METHODS: This study assessed the sleep quality of 39 with non-dialysis CKD (ND CKD) patients and 25 hemodialysis CKD (HD CKD) patients using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Poor sleeper was defined as individual with PSQI > 5.RESULTS: The prevalence of poor sleeper (30% vs. 60%, p=0.029) and the cummulative PSQI (ND CKD 4.5±4.4, HD CKD 8±6, p=0.038) are different between ND CKD and HD CKD groups. Among the ND CKD, there are association between short sleep duration (< 5 hours per day) with elevated diastolic blood pressure groups (r=0.421, p<0.05); habitual sleep efficiency with platelet-to-lymphocyte ratio (r= 0.532, p<0.0001); daytime dysfunction with increased hs-CRP (r=0.345, p=0.032) and neutrophil-to-lymphocyte ratio (r=0.320, p=0.046). In HD CKD group, a requirement to use sleep medication was associated with elevated highsensitivity C-reactive protein (hs-CRP) level (r=0.434, p=0.030) and decreased monocyte-to-lymphocyte ratio (r=- 0.410, p=0.042); daytime dysfunction was associated with serum hs-CRP (r=0.452, p=0.023).CONCLUSION: This study revealed that some features of poor sleep quality in CKD patients including low sleep efficiency, daytime dysfunction and requirement to use sleep medication were associated with increased diastolic blood pressure, hs-CRP and blood-count-based inflammatory predictors. Thus, this finding prompt to pay closer attention to sleep complaints in the management of CVD risk factors in CKD patients.KEYWORDS: sleep quality, chronic kidney disease, blood pressure, inflammation
Diagnosis and Management of Autoimmune Hemolytic Anemia in Systemic Lupus Erythematosus Kahdina, Mega; Nugroho, Cahyo Wibisono
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 2 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i2.52775

Abstract

Autoimmune hemolytic anemia (AIHA) may indicate the first manifestation of systemic lupus erythematosus (SLE). It is estimated that the incidence of AIHA is around 10% in patients with SLE. The first-line therapy for AIHA is corticosteroids. Nevertheless, a second-line therapy may be considered if an adequate response is not obtained. Transfusion indication in AIHA patients do not differ from other types of anemia. These indications include the degree of hemolysis, the progression of anemia, and clinical symptoms. However, blood transfusion for AIHA patients is challenging due to the limited availability of serologically compatible blood. In addition, AIHA patients who receive transfusions have an increased risk of experiencing hemolytic transfusion reactions. In this paper, we aimed to present a case report on the diagnosis of AIHA in an SLE patient treated with second-line therapy and red blood cell transfusions. The patient was a 49-year-old woman who presented with the main complaint of swelling in both legs. According to the medical history, the patient experienced petechia, abdominal distension, body weakness, and weight gain. No reports of joint pain, diarrhea, constipation, fever, shortness of breath, or yellowish skin were made. Before being referred to Dr. Soetomo General Academic Hospital in Surabaya, Indonesia, the patient experienced high blood pressure and body swelling that were unresponsive to treatment. Once the diagnosis of AIHA was confirmed, the patient was set to receive second-line therapy and red blood cell transfusions. At the conclusion of the therapy, the patient exhibited favorable outcomes.   Highlights: 1. This paper presents the management of autoimmune hemolytic anemia in systemic lupus erythematosus, which has been understudied in Indonesia. 2. This paper provides additional evidence regarding the indications and outcomes of red blood cell transfusion in a case of autoimmune hemolytic anemia.
Quantitative and Qualitative Analysis of Antibiotics in the Intensive Care Unit (ICU) Mareta Rindang Andarsari; Lisa Ariyanti Zainu; Sri Rahayu Saleh; Aminatush Sholichah; Dewi Wara Shinta; Cahyo Wibisono Nugroho
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1128

Abstract

The high incidence of infection in the ICU requires frequent use of antibiotics, thereby increasing the risk of developing antibiotic resistance when used irrationally. To assess the quantity and quality of antibiotic use, the World Health Organization (WHO) recommends using the Anatomical Therapeutic Chemical (ATC) classification system or the Defined Daily Dose (DDD) method. In that study, 25 articles were analyzed, including 21 quantitative research articles and four qualitative research articles. These articles were obtained from three databases: PubMed Central (PMC), Research Gate, and Google Scholar. The most commonly used antibiotics in the ICU are ceftriaxone (1×2g, IV) with a DDD value of 358,139/100 bed-days, meropenem (3×2g, IV) with a DDD value of 289,747/100 bed-days, and piperacillin-tazobactam (4×4.5g, IV) with a DDD value of 164,816/100 bed-days. These values indicate the number of antibiotics used in relation to 100 days of sleep. In addition, evaluation of the quality of antibiotic use in the ICU revealed that it is generally characterized by irrational use. By conducting such research, healthcare professionals can optimize the use of antibiotics in the ICU, leading to more effective treatment outcomes while minimizing the development of antibiotic resistance. Keywords: Antibiotics, ATC/DDD, Gyssens, intensive care unit
An ABC-VEN Analysis for Outpatient Medicines Use in the Department of Internal Medicine at Universitas Airlangga Teaching Hospital Zedny Norachuriya; Suprapti, Budi; Dinda Monika Nusantara Ratri; Cahyo Wibisono Nugroho; Yosiyanita Safari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.184-191

Abstract

Background: Application of the ABC-VEN method in evaluating drug planning can increase efficiency and ensure optimal medicine availability and stable access to medications. Objective: To analyze ABC-VEN combinations to examine the profile of medicine use in the internal medicine department. Methods: This was an observational study with retrospective prescription data from outpatients in the Internal Medicine Department from January to March 2020. Collected data included the type, number of medicines, and medicine prices. Patients undergoing chemotherapy and retroviral therapy for HIV were excluded from the study. Subsequently, an ABC-VEN analysis was performed. Results: Of 4,242 prescription samples, 188 types of medicines were used. Based on the drug use evaluation with ABC analysis, category A contained 23 items (12.17%), category B contained 35 items (18.52%), and category C contained 130 items (69.31%). The ABC analysis for investment value found that category A contained eight items (4.23%), category B contained 22 items (11.64%), and 158 items (84.13%). Based on the VEN analysis, Group V had six medicine items, Group E had 152 medicine items, and Group N had 30 medicine items. The ABC-VEN investigation showed that there were eight, 151, and 29 items of medicines in Categories I, I, and III, respectively. Conclusion: Although there are medicines that are highly used, their investment value is quite low. The use of the ABC-VEN method to evaluate medicine use is crucial for organizing and controlling the medicine supply.
Managing diagnostic problem of syphilis manifested as chronic colitis and enteropathic arthritis in a 29 yo male: a case report Auliya, Kamila; Nugroho, Cahyo Wibisono; Mumtaza, Hilya Itsnain
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.17895

Abstract

Syphilis is a chronic sexually transmitted infection caused by Gram-negative bacterium, Treponema pallidum, known for its ability to mimic other diseases, leading to misdiagnosis and delayed treatment. We present a case of a 29 yo male with recurrent acute diarrhea, accompanied by fever, nausea, vomiting, prolonged mouth ulcers, and weight loss for the last three months. He was hospitalized multiple times due to the same recurrent problems. He was initially suspected for immunodeficiency diseases and was screened for HIV and hepatitis B, but both results came out negative. The patient was then suspected with malignancy of the gastrointestinal tract and underwent several examinations including; hematology workup, abdominal X-ray, gastroduodenoscopy, colonoscopy and biopsy. However, the result of all abdominal X-ray, biopsy and colonoscopy ruled out malignancy. The examinations discovered intraluminal ileocecal mass that is consist of lymphocytic cells, therefore the patient was diagnosed with chronic colitis and ileitis. The patient went to the clinic as scheduled with a new chief complain of other symptoms; painful spine and hip join movement, which added to his new diagnose of enterophatic arthritis and he was hospitalized for further diagnosis. During hospitalization, the patient was screened for another venereal disease i.e. syphilis, due to the everchanging symptomatology. He was being screened with VDRL, and later TPHA test. This case encompasses the complexity and challenges of diagnostic workup in non-suggestive findings of the disease syphilis as the Great Imitator.
Co-Authors Aminatush Sholichah Auliya, Kamila Berliana Hamidah Budi Suprapti Dewi Wara Shinta Dinda Monika Nusantara Ratri Djoko Santoso Eka Arum Cahyaning Putri Haerani Rasyid Haerani Rasyid Ika Nindya Kadariswantiningsih Kahdina, Mega Lisa Ariyanti Zainu Mareta Rindang Andarsari Maulana Antiyan Empitu Maulana Muhtadin Suryansyah Maulana Muhtadin Suryansyah Mochammad Amin MOCHAMMAD THAHA Mohammad Yusuf Alsagaff Mohammad Yusuf Alsagaff Mumtaza, Hilya Itsnain Nurina Hasanatuludhhiyah Rieza Rizqi Alda Rieza Rizqi Alda Sri Rahayu Saleh Yosiyanita Safari Yusuke Suzuki Yusuke Suzuki Zaky El Hakim Zaky El Hakim Zedny Norachuriya