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All Journal Biotropika Jurnal Klinik dan Riset Kesehatan
Winstonly, Brian
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Tantangan Dalam Penilaian Klinis Gejala Depresi pada Usia Lanjut Fatma, Siti; Sunarti, Sri; Mardhiyah, Fairuz; Wirabhatari, Astika; Winstonly, Brian
Jurnal Klinik dan Riset Kesehatan Vol 3 No 2 (2024): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.2.6

Abstract

Depresi adalah salah satu gangguan suasana hati yang umum terjadi pada lansia, yang dapat mengurangi kemampuan untuk merehabilitasi diri dan meningkatkan kemungkinan kematian akibat penyakit fisik. Lansia yang mengalami depresi cenderung tidak menunjukkan gejala afektif dan lebih cenderung menunjukkan perubahan kognitif, gejala somatik, dan kehilangan minat dibandingkan lansia yang lebih muda. Hal ini juga sering disalahartikan sebagai efek dari penyakit multipel dan obat-obatan yang digunakan untuk mengobatinya. Faktor risiko yang menyebabkan depresi pada usia lanjut adalah kerentanan genetik, penurunan kognitif, perubahan neurobiologis yang berkaitan dengan usia, insomnia, dan peristiwa yang membuat stres. Terapi kombinasi yaitu terapi perilaku kognitif atau terapi penerimaan dan komitmen dengan obat antidepresan.
Tantangan Dalam Penilaian Klinis Gejala Depresi pada Usia Lanjut Sunarti, Sri; Fatma, Siti; Sunarti, Sr; Mardhiyah, Fairuz; Wirabhatari, Astika; Winstonly, Brian
Jurnal Klinik dan Riset Kesehatan Vol 3 No 2 (2024): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.2.6

Abstract

Depression is one of the common mood disorder of the elderly, which can reduced the ability to rehabilitate and increased the likelihood of death from physical illnessess. Depressed older adults are less likely to endorse affective symptoms and more likely to display cognitive changes, somatic symptoms, and loss of interest than are younger adults. It is also frequently confused with the effects of multipel illnessess and the medicines use to treat them. Risk factors leading to late life depression are genetic vulnerabilities, cognitive diathesis, age associated neurobiological changes, insomnia, and stressful events. Combination therapy is cognitive behavioral therapy or acceptance and commitment therapy with antidepressant drugs.
Genetic Polymorphism Analysis of Progression-Free Survival Rate of Prostate Cancer with Androgen Deprivation Therapy: Frequentist  Network Meta-Analysis Daryanto, Besut; Zümrütbaþ, Ali Ersin; Hakim, Lukman; Negara, Edvin; Janardhana, Alfryan; Setiawan, Ilham Rachmat; Winstonly, Brian; Neville, Neville
Biotropika: Journal of Tropical Biology Vol. 14 No. 1 (2026)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2026.014.01.02

Abstract

Introduction: Various gene mutations play an essential role in the development of prostate cancer (PCa). However, the predictive impact of the HSD3B1 gene on germline and somatic status has not been adequately investigated, regarding such genes, and multi-gene mutations have not been thoroughly discussed. Hence, this study aims to determine the rate of progression and gene polymorphism in Androgen Deprivation Therapy (ADT)-treated prostate cancer. Methods: Research articles were found using MeSH terms and manual entry from PubMed, ScienceDirect, and Google Scholar. Search terms for polymorphism were “SNP”,”single-nucleotide polymorphism”, “polymorphism”, “variation”, or “mutation’, and those for prostate cancer were “prostate cancer”, “prostatic neoplasm”, “cancer of prostate”, “neoplasms, prostate”, “prostate neoplasm”, “prostatic cancer”. All related articles and abstracts were retrieved. Papers were assessed with New Castle-Ottawa Scale and analyzed with REVMAN 4. No low-quality papers were excluded. All paper were reported using Preferred Reporting Items For Systematic Review and Meta-Analysis (PRISMA) Results: Based on the search results, 2520 articles were obtained, and 8 articles were included in this review. The results of pooled log transformed HR and 95% CI as a whole were at CYP17A1 rs 17115100: HR = 1.32 (1.11-1.55); rs 2486758 : HR = 1.59 (1.44-1.75); rs 10883783 : HR = 1.27 (0.99-1.64); HSD17B4 rs 7737181 : HR = 1.11 (1.00-1.22) 95%CI ; HSD3B1 rs 1047303 : HR = 1.57 (1.24-1.99); SRD5A2 rs 523349 : HR = 95% CI. Showed that SRD5A2 rs 523349, HSD3B1 rs 1047303, and CYP17A1 rs 2486758 had a high significance value on HR progression free survival. Conclusion: SRD5A2 rs523349 is the most influential factor in the progression survival rate of patients administered with ADT.
Co-Authors Janardhana, Alfryan Lukman Hakim Mardhiyah, Fairuz Negara, Edvin Neville, Neville Setiawan, Ilham Rachmat Siti Fatma Sri Sunarti Sunarti, Sr Wirabhatari, Astika Zümrütbaþ, Ali Ersin