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All Journal CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Klinik dan Riset Kesehatan
Insanitaqwa, Aleyda
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Analisis Faktor yang Mempengaruhi Peningkatan Serum Transaminase pada Pasien Demam Dengue di RSUD Ngudi Waluyo Wlingi pada Tahun 2023-2024 Wijayanto, Fajar; Insanitaqwa, Aleyda
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.4

Abstract

Background: Dengue fever has become a global and national health concern due to its increasing incidence rate over the past six years. Dengue infection may present with variable sign and symptoms. Major organ involvement may occur, including liver, which is characterized by an elevated transaminase serum level. Aim: This study aims to identify factors contributing to increased transaminase serum levels in patients with dengue fever at Ngudi Waluyo Wlingi General Hospital between 2023-2024. Methods: One hundred and sixty-nine patients with positive dengue serology admitted to Ngudi Waluyo Wlingi General Hospital from January 1st, 2023 to May 19th, 2024, were reviewed retrospectively. Only patients aged 15 years and over with complete laboratory data were included in this retrospective cross-sectional study, using total sampling approach. We collected demographic and laboratory data from electronic medical records, then analyzed and correlated the data with liver function values. Results: Increased AST levels was observed in 70 patients (41.4%), while ALT values was elevated in 32 patients (24.9%). This increase was significantly linked to decreased platelet counts (p=0). Additionally, age was statistically associated with ALT levels (p=0.022), while gender was significantly related to AST levels (p=0.04). However, leukocyte levels and dengue serology showed no significant correlation with serum transaminase levels (p>0.05). Together, dengue serology, platelet counts, leukocyte levels, gender, and age collectively have a significant effect on AST (14.3%) and ALT (13.6%) values. Among these factors, platelet counts exerted the greatest influence on AST and ALT levels. Conclusion: Elevated transaminase serum levels may occur in patients with dengue fever. This is associated with platelet counts, age, and gender. Therefore, diagnosing dengue infection should prompt measurement of liver function to ensure appropriate management according to each patient’s condition.
Analisis Faktor yang Mempengaruhi Peningkatan Serum Transaminase pada Pasien Demam Dengue di RSUD Ngudi Waluyo Wlingi pada Tahun 2023-2024 Wijayanto, Fajar; Insanitaqwa, Aleyda
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.4

Abstract

Background: Dengue fever has become a global and national health concern due to its increasing incidence rate over the past six years. Dengue infection may present with variable sign and symptoms. Major organ involvement may occur, including liver, which is characterized by an elevated transaminase serum level. Aim: This study aims to identify factors contributing to increased transaminase serum levels in patients with dengue fever at Ngudi Waluyo Wlingi General Hospital between 2023-2024. Methods: One hundred and sixty-nine patients with positive dengue serology admitted to Ngudi Waluyo Wlingi General Hospital from January 1st, 2023 to May 19th, 2024, were reviewed retrospectively. Only patients aged 15 years and over with complete laboratory data were included in this retrospective cross-sectional study, using total sampling approach. We collected demographic and laboratory data from electronic medical records, then analyzed and correlated the data with liver function values. Results: Increased AST levels was observed in 70 patients (41.4%), while ALT values was elevated in 32 patients (24.9%). This increase was significantly linked to decreased platelet counts (p=0). Additionally, age was statistically associated with ALT levels (p=0.022), while gender was significantly related to AST levels (p=0.04). However, leukocyte levels and dengue serology showed no significant correlation with serum transaminase levels (p>0.05). Together, dengue serology, platelet counts, leukocyte levels, gender, and age collectively have a significant effect on AST (14.3%) and ALT (13.6%) values. Among these factors, platelet counts exerted the greatest influence on AST and ALT levels. Conclusion: Elevated transaminase serum levels may occur in patients with dengue fever. This is associated with platelet counts, age, and gender. Therefore, diagnosing dengue infection should prompt measurement of liver function to ensure appropriate management according to each patient’s condition.
Dietary Intervention in Hypertension: Mechanisms, Efficacy, and Future Directions Tri Tjahjono, Cholid; Arthamin, Maimun; Prakosa, Ardani; Insanitaqwa, Aleyda
Clinical and Research Journal in Internal Medicine Vol. 6 No. 2 (2025): Volume 6 No 2, November 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2025.006.02.12

Abstract

Hypertension significantly contributes to global cardiovascular morbidity and mortality, with diet being a key modifiable factor in its management. Evidence supports the effectiveness of dietary approaches including the Mediterranean, low-sodium, DASH, and plant-based diets in lowering blood pressure and enhancing cardiovascular health. These benefits are mediated by mechanisms including improved electrolyte balance, minimized oxidative stress, enhanced nitric oxide bioavailability, and favorable modulation of neurohormonal pathways. Despite strong evidence, long-term adherence is hindered by cultural food preferences, limited access to healthy options, and socioeconomic disparities. Emerging approaches, including personalized nutrition, digital health tools, and culturally adapted meal planning, show promise in overcoming these barriers. Additionally, recent insights into nutrient bioavailability, gut microbiota interactions, and gene-diet relationships are reshaping the future of dietary intervention strategies. To maximize impact, healthcare providers must take an active role in delivering tailored dietary guidance as part of routine hypertension care. Multidisciplinary collaboration and community engagement are critical for translating evidence into sustainable practice. Overall, emphasizing diet as a therapeutic tool offers an opportunity to shift the paradigm of hypertension management toward prevention, personalization, and long-term cardiovascular health.
Co-Authors Arthamin, Maimun Prakosa, Ardani Tri Tjahjono, Cholid Wijayanto, Fajar