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All Journal Jurnal Kedokteran Brawijaya Journal of Community Engagement in Health
Ratih Paramita Suprapto
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Healthy Status in the Gymnastic Community in West Bandulan, Sukun, Malang Ratih Paramita Suprapto; Nia Kurnianingsih; Ardani Galih Prakosa; Heri Kristianto; Novita Titis Harbiyanti; Agwin Fahmi Fahanani
Journal of Community Engagement in Health Vol. 7 No. 2 (2024): September
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jceh.v7i2.553

Abstract

Obesity is a risk factor for various degenerative diseases such as diabetes mellitus and coronary heart disease. Obesity and all degenerative diseases could be prevented by implementing a healthy lifestyle, early detection of risk factors for degenerative diseases, and increasing knowledge about degenerative diseases. Therefore, this service activity aimed to form a healthy community with a program for three consecutive months. Activities included healthy exercise once a week, degenerative disease risk factors screening, and health education. Activities were carried out every Sunday morning for three months located in Bandulan Barat, Sukun District, Malang City. This activity was attended by 40 non-menopausal women. Health screening included waist circumference, random blood glucose, uric acid, cholesterol, and blood pressure. Of the 40 women examined, 39 suffered from central obesity, 6 suffered from hypertension, 4 suspected diabetes mellitus, 5 suffered from hyperlipidemia, and 4 of them suffered from hyperuricemia. As an intervention, participants received education about healthy lifestyles and degenerative diseases, the treatment of hypertension, hyperlipidemia, hyperuricemia, and diabetes mellitus. From healthy screening, central obesity was the most prevalent in this women's community. Healthy exercise community activities with health screening, and health education could be effective strategies for promotive and preventive activities to prevent degenerative obesity.
Stem Cells and Exosomes Delivery via Collagen-Based Platform for Advanced Wound Healing: A Systematic Review of In Vivo Studies Ratih Paramita Suprapto; Raras, Tri Yudani Mardining; Kusuma, Ihda Dian
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026): Article in Press 2026
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Chronic wounds remain a global health challenge due to persistent inflammation and impaired cellular function that delay healing. Collagen-based hydrogels are promising delivery platforms for enhancing the therapeutic efficacy of mesenchymal stem cells (MSCs) and exosomes. This review aimed to evaluate the efficacy and molecular mechanisms of MSCs and/or their derived exosomes delivered in collagen-based hydrogels in accelerating wound healing in vivo. This review was managed following PRISMA 2020 guidelines. Literature searches were conducted in PubMed, Scopus, and Europe PMC for original studies published between 2020 and 2025. Eligible studies provided sufficient data describing in vivo chronic wound models treated with collagen scaffolds loaded with MSCs or exosomes. Three in vivo studies using murine burn, diabetic rat, and diabetic rabbit models were included. Each of them used pullulan-collagen seeded with Adipocyte Stem Cells (ASCs), stem cell-derived exosomes combined with recombinant human collagen-methacrylate, and MSC-derived extracellular vesicles (EVs) loaded into collagen hydrogel. All platforms significantly accelerated wound closure versus controls. Histological analyses confirmed enhanced neovascularization, organized collagen deposition, mature granulation tissue formation, and re-epithelization. These effects were mediated by M1-to-M2 macrophage polarization and downregulation of pro-inflammatory cytokines. Cell-free exosome therapy loaded in collagen hydrogels represents a promising approach for chronic wound management.
Stem Cells and Exosomes Delivery via Collagen-Based Platform for Advanced Wound Healing: A Systematic Review of In Vivo Studies Ratih Paramita Suprapto; Raras, Tri Yudani Mardining; Kusuma, Ihda Dian
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.02.11

Abstract

Chronic wounds remain a global health challenge due to persistent inflammation and impaired cellular function that delay healing. Collagen-based hydrogels are promising delivery platforms for enhancing the therapeutic efficacy of mesenchymal stem cells (MSCs) and exosomes. This review aimed to evaluate the efficacy and molecular mechanisms of MSCs and/or their derived exosomes delivered in collagen-based hydrogels in accelerating wound healing in vivo. This review was managed following PRISMA 2020 guidelines. Literature searches were conducted in PubMed, Scopus, and Europe PMC for original studies published between 2020 and 2025. Eligible studies provided sufficient data describing in vivo chronic wound models treated with collagen scaffolds loaded with MSCs or exosomes. Three in vivo studies using murine burn, diabetic rat, and diabetic rabbit models were included. Each of them used pullulan-collagen seeded with Adipocyte Stem Cells (ASCs), stem cell-derived exosomes combined with recombinant human collagen-methacrylate, and MSC-derived extracellular vesicles (EVs) loaded into collagen hydrogel. All platforms significantly accelerated wound closure versus controls. Histological analyses confirmed enhanced neovascularization, organized collagen deposition, mature granulation tissue formation, and re-epithelization. These effects were mediated by M1-to-M2 macrophage polarization and downregulation of pro-inflammatory cytokines. Cell-free exosome therapy loaded in collagen hydrogels represents a promising approach for chronic wound management.
Co-Authors Agwin Fahmi Fahanani Ardani Galih Prakosa Heri Kristianto Ihda Dian Kusuma Nia Kurnianingsih Novita Titis Harbiyanti Tri Yudani MR