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Antioxidant Agent to Improve Endometriosis Related Pain (Dysmenorrhea, Dyspareunia, Pelvic Pain): A Systematic Review and Meta-Analysis Daud, Vanessa Pradna Adyana; Dyarma, Kadiota Rasika; Farida, Leny Silviana
Asian Journal of Health Research Vol. 3 No. 1 (2024): Volume 3 No 1 (April) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i1.142

Abstract

Introduction: Endometriosis is a chronic condition characterized by the presence of endometrial-like tissue outside the uterus, which causes estrogen-induced inflammation. Pelvic severe pain, dysmenorrhea, and dyspareunia are known as the most common symptoms in endometriosis patients. Antioxidants can help alleviate endometriosis-related pain. However, the mechanism is not fully understood. A study is needed to elucidate the inherent potential of an antioxidant in women with endometriosis. Material and Methods: The literature search was conducted in two databases. The outcome of interest is to measure mean changes based on pain severity using the VAS score in endometriosis-related pain, including dysmenorrhea, pelvic pain, and dyspareunia. Some of the antioxidant agents formed in this study are vitamin D, vitamin C, vitamin E, livergol (silymarin), garlic tablets, resveratrol, and melatonin compared to placebo. Meta-analysis was done using RevMan 5.4 using mean change from baseline data with their 95% confidence intervals (CI) provided. Results: Twelve studies meeting the inclusion criteria were considered relevant for assessing the potencies of antioxidants in endometriosis patients (n=695). The antioxidant group had significantly better pelvic pain improvement (MD: -2.21, 95%CI: -3.40 to -1.03, p=0.0003), reduction in dyspareunia symptoms (MD: -1.47, 95% CI: -2.68 to -0.27, p=0.02) as well as improvement in dysmenorrhea with a mean difference -1.92 (95% CI: -3.41 to -0.43, p=0.01) than the placebo group. Antioxidants showed excellent potential to be an alternative treatment in managing endometriosis-related pain, particularly pelvic pain, dyspareunia, and dysmenorrhea. Conclusion: The efficacy of antioxidant agents can be a potential treatment to alleviate pain associated with endometriosis, such as pelvic pain, dysmenorrhea, and dyspareunia.
RADIATION THERAPY FOR ENDOMETRIAL STROMAL SARCOMA: A LITERATURE REVIEW Kusumaningrum, Nadia Nita; Dyarma, Kadiota Rasika; Nugroho, Rafiq Sulistyo; Petrarizky, Alfred Julius
International Journal of Radiology and Imaging Vol. 3 No. 02 (2024): International Journal of Radiology and Imaging
Publisher : Department of Radiology, Medical Faculty, University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijri.2024.003.02.6

Abstract

Background: Endometrial Stromal Sarcoma (ESS) is a part of uterine sarcoma that can clinically manifest with abnormal vaginal bleeding, postmenopausal bleeding, uterine enlargement or mass, dysmenorrhea, pelvic pressure, or pain. ESS is divided into four main categories: endometrial stromal nodule, low-grade ESS, high-grade ESS, and undifferentiated uterine sarcoma. Management for ESS includes surgery, chemotherapy, radiotherapy, and hormone therapy. We want to review the role of radiation therapy for endometrial stromal sarcoma, from several pieces of literature. Material and Methods: We are conducting a literature review to describe the role of radiation therapy for ESS. Results: Radiotherapy serves as an adjuvant treatment in ESS, potentially improving prognosis and survival rates. While early-stage ESS may not necessitate radiotherapy, it can be considered for ESS cases with metastasis or when surgery is not an option. Conclusion: According to previous studies, radiotherapy for ESS can improve disease-free survival and increase patient survival. On the other hand, there are studies that still require large-scale prospective studies to validate the effectiveness of radiotherapy for ESS. Keywords: Endometrial Stromal Sarcoma, Radiotherapy, Effectiveness