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All Journal Jurnal Abdimas Madani dan Lestari (JAMALI) JURNAL ILMIAH SIMANTEK Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
WIJAYANTI, ARINI RIZKY
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Religion Agriculture, Biological Sciences & Forestry Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Other

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UNRAVELING INVASIVE BREAST CARCINOMA OF NO SPECIAL TYPE WITH NEUROENDOCRINE DIFFERENTIATION : A CASE REPORT WIJAYANTI, ARINI RIZKY
JURNAL ILMIAH SIMANTEK Vol 7 No 4 (2023): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Neuroendocrine differentiation in breast cancer has been recognised since 1963 but is hindered by frequently changing terminology and diagnostic criteria. Breast carcinoma of no special type with neuroendocrine differentiation (IBC-NST-NE) is diagnosed by identifying the presence and extent of NE features. This case report emphasises the significance of establishing the IBC-NST-NE diagnosis. A 75-year-old woman presented with a year-old left breast lump, rapidly enlarging over 3 months with multiple ulcerations and bloody nipple discharge. A needle biopsy confirmed ductal carcinoma. Radical mastectomy revealed a 7,5x7,3x4,9 cm, gray-white, lobulated mass with indistinct borders. Histopathology identified invasive ductal carcinoma with 30% exhibiting NE features—arranged in an insular and pseudorosette pattern, composed of polygonal cells with granular cytoplasm and salt-and-pepper chromatin. Synaptophysin and chromogranin A were positive in the neuroendocrine component, leading to the IBC-NST-NE diagnosis. Therapy of IBC-NST-NE follows standard IBC protocol; however, it has shorter disease-free survival, a poorer survival rate, higher distant metastasis rates, and a higher TNM stage at diagnosis. Diagnosing IBC-NST-NE is crucial for prognosis and enhances our understanding of neuroendocrine differentiation behaviour in breast cancer.
Pendekatan Diagnosis Lesi Kistik pada Pankreas: Sebuah Tinjauan Pustaka Wijayanti, Arini Rizky; Iramawasita, Yayuk
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol2.iss2.art13

Abstract

Kejadian pancreatic cystic lesion (PCL) berkisar 4-14% populasi umum dan terus meningkat dengan beragam gambaran karakteristik demografi, klinis, morfologi dan histologis. Diagnosis akurat sangat penting, mengingat lesi-lesi kistik ini dapat berkembang menjadi keganasan ataupun terjadi secara bersamaan sehingga mempengaruhi penatalaksanaannya. Untuk menegakan diagnosis PCL diperlukan pendekatan multidisiplin yang memadukan informasi klinis, radiologis dan patologis. Modalitas radiologis yang dapat digunakan berupa ultrasonografi, endoscopic ultrasound, computerized tomography (CT) atau magnetic resonance imaging (MRI). Modalitas diagnosis radiologis yang terbaik untuk setiap lesi dapat berbeda-beda. Fine needle aspiration (FNA), pemeriksaan histopatologi, sitologi, imunohistokimia, histokimia atau deteksi mutasi genetik merupakan modalitas diagnostik patologi yang dapat dipergunakan untuk menegakan diagnosis. Dengan mengkombinasikan temuan klinis, radiologi dan patologi diharapkan lesi dapat ditegakan dengan lebih akurat. Oleh karena itu tinjauan pustaka ini bertujuan untuk membahas pendekatan diagnosis PCL dengan menggabungkan sudut pandang multidisiplin.
Pencegahan kanker serviks dengan Penyuluhan dan Pemeriksaan Pap Smear di Kedaton, Pleret, Bantul: Indonesia Wijayanti, Arini Rizky; Luki Tiara, Dinda; Widayati, Sri; Kharisma, Muhammad
Jurnal Abdimas Madani dan Lestari (JAMALI) Volume 06, Issue 02, September 2024
Publisher : UII

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jamali.vol6.iss2.art3

Abstract

Cervical cancer is the second most common type of cancer in Indonesia. One of the factors affecting the high incidence of cervical cancer in Indonesia is the low coverage of screening and early detection, such as Pap smear. The low coverage is caused by various factors, including health system and lack of public awareness. Therefore, this community service focus on cervical cancer counseling and Pap smear examination. The purpose of this activity are to increase public awareness of cervical cancer and the coverage of cervical cancer screening in community. The activity was carried out in Kedaton, Pleret, Bantul with 26 participants. As many as 57.69% of the participants  were first-time Pap smear takers. Pap smear diagnostic results showed that all participant did not have cervical epithelial abnormalities leading to malignant lesion (Negative for Intraepithelial Malignancy) but there were participant with epithelial reactive changes due to inflammation (23.08%), actinomycosis (15,38%), bacterial vaginosis (11.54%) and IUD-related reactive changes (3.8%). The majority of patients with reactive changes and infection of the cervix had no complaints, indicating a lack of understanding the sign of  abnormal vaginal discharge. This community service is effective to prevent cervical cancer and increase knowledge about gynecological and reproductive health. However it still requires the cooperation of many parties to expand Pap smear coverage and implementation of periodic examination.
PENDEKATAN DIAGNOSIS LESI KISTIK REGIO COLLI: DIAGNOSTIC APPROACH OF CYSTIC NECK LESION Wijayanti, Arini Rizky; Setiyandari, Bernadeta Hernik; Saputra, Lili Ananta
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 25 No. 1 (2026): Januari 2026
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v25i1.1036

Abstract

Lesi kistik di regio colli merupakan temuan klinis yang sering dijumpai dan memiliki variasi etiologi yang luas, mulai dari kelainan bawaan, infeksi dan neoplasma. Penegakan diagnosis yang tepat sangat penting untuk menentukan terapi yang sesuai dan mencegah komplikasi. Tinjauan pustaka naratif ini dilakukan melalui pencarian literatur pada Google Scholar antara tahun 2015–2025 dengan kata kunci: “cystic neck lesion”, “neck cyst”, “diagnostic approach”, “ultrasound”, “CT”, “MRI”, dan “fine needle aspiration”. Kriteria inklusi meliputi artikel yang membahas aspek diagnostik lesi kistik leher pada manusia, berbahasa inggris atau indonesia, dan diterbitkan tahun 2015–2025. Artikel yang tidak relevan, duplikasi, atau tanpa akses teks penuh dikeluarkan. Dari 17.100 artikel, 29 artikel memenuhi kriteria dan dianalisis secara kualitatif. Pemeriksaan klinis dengan pendekatan lokasi, pencitraan (ultrasonografi/ USG, CT scan, MRI) dan sitopatologi (fine needle aspiration biopsy/ FNAB) memiliki peran komplementer dalam diagnosis lesi kistik di regio colli. Pemeriksaan USG merupakan modalitas pemeriksaan penunjang awal paling efektif, sementara CT scan/MRI memberikan karakterisasi lebih mendalam dan menilai keterlibatan jaringan sekitar. Pemeriksaan FNAB membantu membedakan proses infeksi dan neoplasma, meskipun sensitivitasnya menurun pada lesi yang bersifat kistik. Kombinasi multimodal meningkatkan akurasi diagnostik. Kesimpulan: Pendekatan multidisiplin yang mengintegrasikan data klinis, radiologis, dan sitopatologis disarankan untuk diagnosis komprehensif lesi kistik ldi regio colli.
Co-Authors Iramawasita, Yayuk KHARISMA, MUHAMMAD Luki Tiara, Dinda SAPUTRA, LILI ANANTA Setiyandari, Bernadeta Hernik Sri Widayati