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UNRAVELING INVASIVE BREAST CARCINOMA OF NO SPECIAL TYPE WITH NEUROENDOCRINE DIFFERENTIATION : A CASE REPORT WIJAYANTI, ARINI RIZKY
JURNAL ILMIAH SIMANTEK Vol 7 No 4 (2023): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Neuroendocrine differentiation in breast cancer has been recognised since 1963 but is hindered by frequently changing terminology and diagnostic criteria. Breast carcinoma of no special type with neuroendocrine differentiation (IBC-NST-NE) is diagnosed by identifying the presence and extent of NE features. This case report emphasises the significance of establishing the IBC-NST-NE diagnosis. A 75-year-old woman presented with a year-old left breast lump, rapidly enlarging over 3 months with multiple ulcerations and bloody nipple discharge. A needle biopsy confirmed ductal carcinoma. Radical mastectomy revealed a 7,5x7,3x4,9 cm, gray-white, lobulated mass with indistinct borders. Histopathology identified invasive ductal carcinoma with 30% exhibiting NE features—arranged in an insular and pseudorosette pattern, composed of polygonal cells with granular cytoplasm and salt-and-pepper chromatin. Synaptophysin and chromogranin A were positive in the neuroendocrine component, leading to the IBC-NST-NE diagnosis. Therapy of IBC-NST-NE follows standard IBC protocol; however, it has shorter disease-free survival, a poorer survival rate, higher distant metastasis rates, and a higher TNM stage at diagnosis. Diagnosing IBC-NST-NE is crucial for prognosis and enhances our understanding of neuroendocrine differentiation behaviour in breast cancer.
Pendekatan Diagnosis Lesi Kistik pada Pankreas: Sebuah Tinjauan Pustaka Wijayanti, Arini Rizky; Iramawasita, Yayuk
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol2.iss2.art13

Abstract

Kejadian pancreatic cystic lesion (PCL) berkisar 4-14% populasi umum dan terus meningkat dengan beragam gambaran karakteristik demografi, klinis, morfologi dan histologis. Diagnosis akurat sangat penting, mengingat lesi-lesi kistik ini dapat berkembang menjadi keganasan ataupun terjadi secara bersamaan sehingga mempengaruhi penatalaksanaannya. Untuk menegakan diagnosis PCL diperlukan pendekatan multidisiplin yang memadukan informasi klinis, radiologis dan patologis. Modalitas radiologis yang dapat digunakan berupa ultrasonografi, endoscopic ultrasound, computerized tomography (CT) atau magnetic resonance imaging (MRI). Modalitas diagnosis radiologis yang terbaik untuk setiap lesi dapat berbeda-beda. Fine needle aspiration (FNA), pemeriksaan histopatologi, sitologi, imunohistokimia, histokimia atau deteksi mutasi genetik merupakan modalitas diagnostik patologi yang dapat dipergunakan untuk menegakan diagnosis. Dengan mengkombinasikan temuan klinis, radiologi dan patologi diharapkan lesi dapat ditegakan dengan lebih akurat. Oleh karena itu tinjauan pustaka ini bertujuan untuk membahas pendekatan diagnosis PCL dengan menggabungkan sudut pandang multidisiplin.
Pencegahan kanker serviks dengan Penyuluhan dan Pemeriksaan Pap Smear di Kedaton, Pleret, Bantul: Indonesia Wijayanti, Arini Rizky; Luki Tiara, Dinda; Widayati, Sri; Kharisma, Muhammad
Jurnal Abdimas Madani dan Lestari (JAMALI) Volume 06, Issue 02, September 2024
Publisher : UII

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jamali.vol6.iss2.art3

Abstract

Cervical cancer is the second most common type of cancer in Indonesia. One of the factors affecting the high incidence of cervical cancer in Indonesia is the low coverage of screening and early detection, such as Pap smear. The low coverage is caused by various factors, including health system and lack of public awareness. Therefore, this community service focus on cervical cancer counseling and Pap smear examination. The purpose of this activity are to increase public awareness of cervical cancer and the coverage of cervical cancer screening in community. The activity was carried out in Kedaton, Pleret, Bantul with 26 participants. As many as 57.69% of the participants  were first-time Pap smear takers. Pap smear diagnostic results showed that all participant did not have cervical epithelial abnormalities leading to malignant lesion (Negative for Intraepithelial Malignancy) but there were participant with epithelial reactive changes due to inflammation (23.08%), actinomycosis (15,38%), bacterial vaginosis (11.54%) and IUD-related reactive changes (3.8%). The majority of patients with reactive changes and infection of the cervix had no complaints, indicating a lack of understanding the sign of  abnormal vaginal discharge. This community service is effective to prevent cervical cancer and increase knowledge about gynecological and reproductive health. However it still requires the cooperation of many parties to expand Pap smear coverage and implementation of periodic examination.