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All Journal E-Jurnal Medika Udayana Indonesian Journal of Biomedicine and Clinical Sciences
Jayakusuma, I Putu Prabawa
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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PROFIL KLINIKOPATOLOGI PASIEN LESI PRAKANKER SERVIKS YANG MENJALANI LOOP ELECTROSURGICAL EXCISION PROCEDURE (LEEP) DI RSUP SANGLAH TAHUN 2016 – 2020 Jayakusuma, I Putu Prabawa; Ekawati, Ni Putu; Sumadi, I Wayan Juli; Saputra, Herman
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P12

Abstract

Loop Electrosurgical Excision Procedure (LEEP) adalah tindakan pemotongan sel abnormal pada serviks menggunakan wire loop yang dialiri aliran listrik. LEEP merupakan salah satu penatalaksanaan pasien lesi prakanker serviks. Penelitian ini bertujuan untuk mengetahui gambaran profil klinikopatologi pasien lesi prakanker serviks yang menjalani Loop Electrosurgical Excision Procedure (LEEP) di RSUP Sanglah tahun 2016 – 2020. Penelitian ini merupakan penelitian deskriptif cross-sectional. Sampel dipilih berdasarkan kriteria inklusi dan eksklusi. Data diolah menggunakan software SPSS ver. 26 untuk mendapatkan karakteristik profil pasien lesi prakanker yang menjalani prosedur Loop Electrosurgical Excision Procedure (LEEP) yang terdiri dari usia, diagnosis klinis, dan diagnosis histopatologis. Hasil penelitian menunjukkan bahwa pasien lesi prakanker yang menjalani prosedur Loop Electrosurgical Excision Procedure (LEEP) di RSUP Sanglah Denpsar Bali pada tahun 2016-2020 sebanyak 37% dari kelompok umur 31-40 tahun. Diantara pasien lesi prakanker yang menjalani prosedur Loop Electrosurgical Excision Procedure (LEEP) 37% diagnosis klinis adalah ASCUS. Hasil diagnosis histopatologis terbanyak adalah HSIL (33,3%) dan non lesi prakanker (33,3%).
Clinical effects of Spirulina supplementation on hemoglobin levels in anemic pregnant women: a systematic review and meta-analysis Budi Gunawan, Made Favian; Soetomo, Cindy Thiovany; Darmayasa, Putu Bagus; Paramyta, I Gusti Ayu Cintya; Jayakusuma, I Putu Prabawa; Gunawan, I Made Indera
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 1 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i1.23573

Abstract

Anemia during pregnancy continues to pose a significant burden, particularly in low- and middle-income countries (LMICs). Anemia is a major contributor in increasing maternal illness and negative pregnancy outcomes. Spirulina, a nutrient-dense blue-green alga rich in bioavailable iron, has gained attention as a potential nutritional intervention to support hemoglobin improvement in pregnancy. This systematic review and meta-analysis, adhering to PRISMA standards, sought to assess the impact of Spirulina supplementation on improving hemoglobin levels among pregnant women. A single-arm meta-analysis was performed to assess the change in hemoglobin levels before and after Spirulina supplementation, while a comparative meta-analysis evaluated the mean difference in hemoglobin improvement between Spirulina and standard iron supplementation. Four eligible studies involving 1,070 pregnant women were included. The single-arm analysis demonstrated a significant increase in hemoglobin levels following Spirulina supplementation, with a pooled mean difference (MD) of 1.81 g/dL (95% CI: 0.24 - 3.39; p = 0.024). In the comparative analysis, Spirulina showed a non-significant trend toward higher hemoglobin than standard iron, with a pooled MD of 1.45 g/dL (95% CI: –0.22 - 3.13; p = 0.088). Risk of bias was low to moderate, and the overall certainty of evidence was classified as moderate. These findings suggest that Spirulina may be a promising adjunct for improving maternal hemoglobin, particularly in settings where local cultivation and food-based approaches are preferred. Further high-quality randomized trials are recommended to ascertain its clinical efficacy and inform policy on its integration into maternal nutrition programs.
Co-Authors Budi Gunawan, Made Favian Darmayasa, Putu Bagus Gunawan, I Made Indera Herman Saputra I Wayan Juli Sumadi Ni Putu Ekawati Paramyta, I Gusti Ayu Cintya Soetomo, Cindy Thiovany