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All Journal E-Jurnal Medika Udayana Jurnal Biodjati Jurnal Pembelajaran dan Biologi Nukleus
Wulansari, Shahnaz Shabrina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology

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PEMBERIAN INFUSA KOMBINASI BUNGA Hibiscus rosa-sinensis L DAN DAUN Annona muricata L. PADA MENCIT YANG DIINDUKSI HIPERURISEMIA Lestari, Dian Fita; Fatimatuzzahra, .; Sianipar, Agnes Petra; Wulansari, Shahnaz Shabrina; Helmiyetti, .
E-Jurnal Medika Udayana Vol 13 No 1 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i01.P09

Abstract

Prevalensi hiperurisemia mengalami peningkatan dalam beberapa dekade terakhir yang seringkali disebabkan oleh pola makan dengan kandungan makanan tinggi purin. Purin juga terdapat dalam DNA sel tubuh yang akan juga dirombak, sehingga kadar asam urat dalam darah dapat semakin tinggi karena asupan dari makanan. Kadar asam urat dapat diturunkan dengan obat anti-hiperurisemia, salah satunya allopurinol, namun penggunaan jangka panjang dapat mengakibatkan efek berbahaya pada organ tubuh. Bunga kembang sepatu (Hibiscus rosa-sinensis L.) dan daun sirsak (Annona muricata L.) mengandung metabolit sekunder yang berpotensi sebagai anti-hiperurisemia. Tujuan dari penelitian ini untuk mengetahui keefektivitasan infusa kombinasi bunga kembang sepatu dan daun sirsak terhadap kadar asam urat mencit yang diinduksi hiperurisemia. Mencit dibagi menjadi 6 kelompok perlakuan, K0 (kontrol negative), K1 kontrol hiperurisemia (kalium oksonat dan jus hati ayam), K2 (kontrol positif menggunakan allopurinol 10mg/kgBB), K3 (infusa 25%), K4 (infusa 35%), K5 (infusa 45%). Berdasarkan hasil penelitian menunjukkan bahwa kombinasi infusa bunga kembang sepatu-daun sirsak dapat menurunkan kadar asam urat darah mencit jantan strain DDY yang diinduksi hiperurisemia menggunakan kalium oksonat dan jus hati ayam. Kelompok K2 (kontrol positif) menggunakan allopurinol terjadi penurunan kadar asam urat sebesar 56,2%. Sedangkan menggunakan infusa dapat menurunkan kadar asam urat mencit dengan konsentrasi terbaik 25% jika dibandingkan dengan kelompok konsentrasi infusa yang lain, dengan persentase penurunan kadar asam urat darah sebesar 44,11%. Hal ini menunjukkan bahwa infusa kombinasi bunga kembang sepatu dan daun sirsak memiliki potensi sebagai anti hiperurisemia.
Hepatoprotective Activity of Hibiscus Flowers (Hibiscus rosa-sinensis) and Soursop Leaves (Annona muricata) Mix Infusion in Mus musculus Post Hyperuricemia Induction Lestari, Dian Fita; Atmaja, Vestidhia Yunisya; Fatimatuzzahra, Fatimatuzzahra; Wulansari, Shahnaz Shabrina; Febrianti, Eliza
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.6931

Abstract

Background: Liver has many functions in the metabolic system and detoxification of substances that are harmful to the body. Chemical intoxication due to drug use might induce liver damage. A histology examination can indicate liver damage induced by a chemical substance, as well as the condition of tissue structure and function associated with the disease. This study aims to investigate the hepatoprotective effect of mix infusion of hibiscus flowers and soursop leaves on the liver histological structure in mice induced by hyperuricemia using potassium oxonate. Methodology: This study used an experimental group design, involving 8-week-old mice. The groups were divided as follows: A1 (control), A2 (Potassium oxonate), A3 (allopurinol), A4 (infusion 25 %), A5 (infusion 35 %), and A6 (infusion 45 %). Histological image was examined using an optilab with five fields of view. Findings: The study's revealed that the control group had a normal liver histology structure, whereas the hyperuricemia treatment group experienced significant liver damage, including congestion and leukocyte infiltration, and the allopurinol treatment group experienced significant damage, including leukocyte infiltration and necrosis. Therapy with a combined infusion of hibiscus flowers and soursop leaves shown a hepatoprotective effect. Based on histological analysis, the 25 % concentration provided the greatest hepatoprotective impact when compared to other infusion concentration. Mix infusion of hibiscus flowers and soursop leaves demonstrates heproprotective activity in hyperuricemia mice induced by potassium oxonate. Contribution: This study demonstrates that the mix infusion of hibiscus flowers and soursop leaves has the potential to be a hepatoprotective agent, but further research is needed regarding long-term effects
Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus) Lestari, Dian Fita; Fatimatuzzahra, Fatimatuzzahra; Sianipar, Agnes Petra; Wulansari, Shahnaz Shabrina
Jurnal Biodjati Vol 7 No 2 (2022): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i2.18616

Abstract

Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine. However, consumption of the drugs can cause side effects on the liver. The aim of the research was to determine the effect of allopurinol induction on the liver histopathology of male mice (Mus musculus) DDY strain. The method used in this research was an experimental design used post-test only that was divided into 4 groups of 4 mice per group. The control group (P0) was given 0.5% Na-CMC, and groups I, II, and III (P1, P2, and P3) were induced by allopurinol at 10 mg/kg BW, 20 mg/kg BW, and 30 mg/kg BW for 14 days. Allopurinol induction was performed by oral gavage. The results of the research showed that treatment with allopurinol caused changes in the mice’s body weight, liver index, liver morphology, and histological structure of the liver tissue, including necrosis, steatosis, leukocyte infiltration, binuclear hepatocytes, hepatocyte swelling, congestion, sinusoid dilatation, and hemorrhage. The level of liver damage increased in line with the dose used. This research indicated that the higher the allopurinol level, the higher the level of alteration in the liver section structure. Long-term use of allopurinol can cause damage to the structure of mice liver (liver toxicity). 
Co-Authors Atmaja, Vestidhia Yunisya Fatimatuzzahra Fatimatuzzahra Fatimatuzzahra, . Febrianti, Eliza Helmiyetti, . Lestari, Dian Fita Sianipar, Agnes Petra