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All Journal E-Jurnal Medika Udayana Biosfer: Jurnal Tadris Biologi Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ilmiah Biologi UMA (JIBIOMA) Indonesian Journal of Laboratory Jurnal Pengabdian Pada Masyarakat Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Lestari, Dian Fita
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PEMBERIAN INFUSA KOMBINASI BUNGA Hibiscus rosa-sinensis L DAN DAUN Annona muricata L. PADA MENCIT YANG DIINDUKSI HIPERURISEMIA Lestari, Dian Fita; Fatimatuzzahra, .; Sianipar, Agnes Petra; Wulansari, Shahnaz Shabrina; Helmiyetti, .
E-Jurnal Medika Udayana Vol 13 No 1 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i01.P09

Abstract

Prevalensi hiperurisemia mengalami peningkatan dalam beberapa dekade terakhir yang seringkali disebabkan oleh pola makan dengan kandungan makanan tinggi purin. Purin juga terdapat dalam DNA sel tubuh yang akan juga dirombak, sehingga kadar asam urat dalam darah dapat semakin tinggi karena asupan dari makanan. Kadar asam urat dapat diturunkan dengan obat anti-hiperurisemia, salah satunya allopurinol, namun penggunaan jangka panjang dapat mengakibatkan efek berbahaya pada organ tubuh. Bunga kembang sepatu (Hibiscus rosa-sinensis L.) dan daun sirsak (Annona muricata L.) mengandung metabolit sekunder yang berpotensi sebagai anti-hiperurisemia. Tujuan dari penelitian ini untuk mengetahui keefektivitasan infusa kombinasi bunga kembang sepatu dan daun sirsak terhadap kadar asam urat mencit yang diinduksi hiperurisemia. Mencit dibagi menjadi 6 kelompok perlakuan, K0 (kontrol negative), K1 kontrol hiperurisemia (kalium oksonat dan jus hati ayam), K2 (kontrol positif menggunakan allopurinol 10mg/kgBB), K3 (infusa 25%), K4 (infusa 35%), K5 (infusa 45%). Berdasarkan hasil penelitian menunjukkan bahwa kombinasi infusa bunga kembang sepatu-daun sirsak dapat menurunkan kadar asam urat darah mencit jantan strain DDY yang diinduksi hiperurisemia menggunakan kalium oksonat dan jus hati ayam. Kelompok K2 (kontrol positif) menggunakan allopurinol terjadi penurunan kadar asam urat sebesar 56,2%. Sedangkan menggunakan infusa dapat menurunkan kadar asam urat mencit dengan konsentrasi terbaik 25% jika dibandingkan dengan kelompok konsentrasi infusa yang lain, dengan persentase penurunan kadar asam urat darah sebesar 44,11%. Hal ini menunjukkan bahwa infusa kombinasi bunga kembang sepatu dan daun sirsak memiliki potensi sebagai anti hiperurisemia.
Variasi Pola Sidik Jari dan Pola Palmar pada Masyarakat Suku Rejang Bengkulu Resiliani, Tiara; Kamilah, Santi Nurul; Lestari, Dian Fita; Jarulis, Jarulis; Sipriyadi, Sipriyadi; Muslim, Choirul
Jurnal Ilmiah Biologi UMA (JIBIOMA) Vol 5, No 2 (2023): November
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/jibioma.v5i2.1775

Abstract

The Rejang tribe is one of the indigenous communities in Bengkulu. They are dispersed throughout several areas of Bengkulu, however, the majority of them live in the Rejang Lebong district. The Rejang tribe is classified as a Malayan Mongoloid race. Generally, every tribe has distinctive characteristics. These characteristics include language, culture, religion, and physical characteristics. The purpose of this study was to analyze the characteristics of the Rejang tribal community residing in Pematang Sapang village, North Bengkulu, with a focus on their fingerprint and palm patterns. Data was gathered from 100 individuals of the Rejang tribe, who fulfilled the inclusion criteria. The data was analyzed quantitatively. The study determined that there are three fingerprint patterns in the Rejang community, with the loop pattern being most prevalent at 59.8%. There are only two palmar patterns; normal and simian, with the normal pattern being dominant at 94.5%. Statistical analysis revealed no significant correlation between fingerprint or palmar patterns and sex. Furthermore, there was no observable relationship between fingerprint and palmar patterns.  The Rejang tribe is characterized by the prevalence of the loop patterns for fingerprints and the normal patterns for palmar.
Pembuatan Preparat Awetan Embrio Utuh Burung Puyuh (Cortunix - Cortunix Japonica) Aprira, Aprira; Edward, Edward; Lestari, Dian Fita
Indonesian Journal of Laboratory Vol 6 No 3 Tahun 2023
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijl.v1i3.90730

Abstract

Salah satu materi praktikum Embriologi Pekembangan Hewan adalah kegiatan pengamatan pekembangan embrio hewan kelas Aves. Pada praktikum ini mahasiswa menggunakan salah satu bahan yang berupa preparat awetan yang tersedia di laboratorium. Kegiatan praktikum meliputi pengamatan dari perkembanagn embrio ayam usia 18,24,36, 48,60, 72 dan 96 jam. Sediaan preparat awetan dari spesies aves yang berbeda diperlukan sebagai perbandingan perkembangan embrio. Salah satu spesies aves yang cukup mudah didapatkan sediaan telur dengan waktu perkembangan embrio yang cukup berbeda dibandingkan dengan ayam adalah burung dari jenis cortunix-cortunix japonica atau burung puyuh. Sedian preparat awetan embrio utuh ini sangat penting untuk meningkatkan kelancaran dan peningkatan pengetahuan mahasiswa. Penelitian dilakukan dengan tujuan untuk membuat preparat awetan utuh embrio burung puyuh pada masa inkubasi 24,36,48,60,72,84 dan 96 jam. Sampel yang digunakan adalah telur puyuh fertil  yang diinkubasi pada suhu 380C. Embrio akan dipisahkan dari kuning telur, lalu embrio dibersihkan, di warnai dan dijernihkan dengan menggunakan alkohol bertingkat dan xylol sehingga perkembangan dari masing masing embrio terlihat jelas. Dapat disimpulkan yaitu telur burung puyuh fertil yang diinkubasi dengan masa inkubasi 24,36,48,60,72,84, dan 96 jam, embrionya dapat dipisahkan dan dapat dibuat preparat utuh serta dapat diamati di mikroskop Preparat dari embrio burung puyuh perkembangannya hampir mirip dengan embrio ayam tetapi pada umur inkubasi yang sama embrio burung puyuh telah mengalami tehapan perkembangan yang lebih lanjut dari pada embrio ayam.
Pencegahan Risiko Penularan Infeksi Saluran Pernapasan Atas (ISPA) dari Penggunaan Alat Selam Bersama pada Kelompok Penyelam di Pulau Enggano Atmaja, Vestidhia Yunisya; Kamilah, Santi Nurul; Lestari, Dian Fita; Lubis, Ashar Muda; Sipriyadi, Sipriyadi; Bastian, Muhammad Chandra; Wulandari, Gustina Dwi; Utama, Ahmat Fakhri
Jurnal Pengabdian Pada Masyarakat Vol 9 No 1 (2024): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v9i1.649

Abstract

Penyakit yang dapat disebabkan akibat penggunaan alat selam secara bersama yang tidak aseptik yaitu Infeksi Saluran Pernapasan Akut (ISPA). ISPA merupakan penyakit yang menginfeksi saluran pernapasan atas dan menginfeksi seluruh bagian pernapasan bawah (alveoli). ISPA dapat menular melalui droplet mengandung virus atau bakteri terhirup oleh orang sehat. Penggunaan alat selam secara langsung akan bersentuhan dengan bagian mulut dan hidung, apabila perawatan alat penyelaman kurang tepat akan menimbulkan adanya risiko penularan ISPA. Kelompok penyelam di Pulau Enggano menggunakan alat selam bersama untuk aktivitas mencari ikan dan menyewakan untuk para wisatawan. Namun para penyelam masih minim pengetahuan terkait dampak risiko penyakit dari penggunaan alat selam bersama. Kegiatan dihadiri oleh perwakilan 5 kelompok penyelam yang ada di Pulau Enggano. Kegiatan pengabdian meliputi pembukaan, sosialisasi, pelatihan mengenai cara membersihkan alat selam yang benar, tanya jawab, evaluasi kegiatan, dan penutupan. Hasil evaluasi dari kegiatan ini, kelompok penyelam menilai sangat bermanfaat dan membantu meningkatkan pengetahuan peserta. Para penyelam menjadi sadar akan pentingnya kebersihan dan perawatan alat selamnya. Secara umum, berdasarkan hasil evaluasi, menunjukkan bahwa masyarakat puas dengan pelaksanaan kegiatan ini dan mengucapkan terima kasih atas penyerahan alat dan bahan pembersih alat selam untuk kelompok penyelam. Pemahaman dan penerapan aseptik pada alat selam ini perlu dilakukan secara berkelanjutan agar menjadi nilai lebih untuk kelompok penyelam. Tidak hanya untuk kesehatan para penyelam yang mencari ikan namun juga untuk wisatawan yang hendak menggunakan alat selam. Diseases that can be caused by sharing diving equipment that is not aseptic are Acute Respiratory Infections (ARI). ARI is a disease that infects the upper respiratory tract and infects the entire lower respiratory tract (alveoli). ARI can be transmitted through droplets containing viruses or bacteria inhaled by healthy people. Using diving equipment will directly come into contact with the mouth and nose, if the diving equipment is not maintained properly it will pose a risk of transmitting ARI. Groups of divers on Enggano Island use diving equipment together for fishing activities and rent them out to tourists. However, divers still lack knowledge regarding the impact of disease risks from using shared diving equipment. The activity was attended by representatives of 5 diving groups on Enggano Island. Service activities include opening, socialization, training on how to properly clean diving equipment, questions and answers, activity evaluation, and closing. As a result of the evaluation of this activity, the diving group considered it very useful and helped increase the participants' knowledge. Divers become aware of the importance of cleanliness and maintenance of their diving equipment. In general, based on the evaluation results, it showed that the community was satisfied with the implementation of this activity and expressed their gratitude for the delivery of diving equipment and cleaning materials to the diving group. The understanding and application of aseptics in diving equipment needs to be carried out on an ongoing basis so that it becomes an added value for groups of divers. Not only for the health of divers looking for fish but also for tourists who want to use diving equipment.
Analysis of Liver Histology Several Fish in the Air Kotok River in the Gold Mining Area, Lebong Regency Lestari, Dian Fita; Febrianti, Eliza; Wulansari, Shahnaz Sabrina; Putra, Apriza Hongko
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 9, No 2: Jurnal Pembelajaran Dan Biologi Nukleus July 2023
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i2.4020

Abstract

Fish have habitats that are easily exposed to contamination from the environment such as heavy metal waste which can cause changes in the structure and function of body tissues. One type of waste that enters the river in the Lebong Regency River is gold mining processing waste that uses mercury and cyanide. Heavy metals can enter organisms and accumulation and biomagnification of mercury can occur in the bodies of aquatic biota such as fish. There has been no research related to fish histology in the Lebong gold mining area, so the aim of this research was to determine the histological condition of the liver organs of several fish in the form of Hemibagrus nemurus, Rasbora sp, Trichogaster trichopterus, and Macrognathus circumcinctus in the Air Kotok river in the gold mining area of Lebong Regency. The research was conducted using the paraffin method with hematoxylin-eosin staining. Data were analyzed descriptively qualitatively based on the histology of the fish liver. The results of the research on the liver histology, it shows damage to the fish liver structure which includes vacuolization, congestion, pyknosis, dilated sinusoids, melanomacrophages and leukocyte infiltration. The damage to the hepatocytes of this fish can be used as a bio-indicator of exposure to toxic substances in the Air Kotok river, one of which is heavy metal activity from gold mining, which can be a threat to the health and survival of the fish.Keywords: Bengkulu, gold mining waste, heavy metal, hepa
Hepatoprotective Activity of Hibiscus Flowers (Hibiscus rosa-sinensis) and Soursop Leaves (Annona muricata) Mix Infusion in Mus musculus Post Hyperuricemia Induction Lestari, Dian Fita; Atmaja, Vestidhia Yunisya; Fatimatuzzahra, Fatimatuzzahra; Wulansari, Shahnaz Shabrina; Febrianti, Eliza
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.6931

Abstract

Background: Liver has many functions in the metabolic system and detoxification of substances that are harmful to the body. Chemical intoxication due to drug use might induce liver damage. A histology examination can indicate liver damage induced by a chemical substance, as well as the condition of tissue structure and function associated with the disease. This study aims to investigate the hepatoprotective effect of mix infusion of hibiscus flowers and soursop leaves on the liver histological structure in mice induced by hyperuricemia using potassium oxonate. Methodology: This study used an experimental group design, involving 8-week-old mice. The groups were divided as follows: A1 (control), A2 (Potassium oxonate), A3 (allopurinol), A4 (infusion 25 %), A5 (infusion 35 %), and A6 (infusion 45 %). Histological image was examined using an optilab with five fields of view. Findings: The study's revealed that the control group had a normal liver histology structure, whereas the hyperuricemia treatment group experienced significant liver damage, including congestion and leukocyte infiltration, and the allopurinol treatment group experienced significant damage, including leukocyte infiltration and necrosis. Therapy with a combined infusion of hibiscus flowers and soursop leaves shown a hepatoprotective effect. Based on histological analysis, the 25 % concentration provided the greatest hepatoprotective impact when compared to other infusion concentration. Mix infusion of hibiscus flowers and soursop leaves demonstrates heproprotective activity in hyperuricemia mice induced by potassium oxonate. Contribution: This study demonstrates that the mix infusion of hibiscus flowers and soursop leaves has the potential to be a hepatoprotective agent, but further research is needed regarding long-term effects
Histopathology of Gills Fish in Rivers Contaminated by Heavy Metals from Artisanal Gold Mining Waste in Lebong Regency, Bengkulu Province Lestari, Dian Fita; Vestidhia Yunisya Atmaja; Santi Nurul Kamilah; Eliza Febrianti; Farisa Retno; Hengki Turnando; Ibranio Risditama
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 02 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss02/588

Abstract

The aquatic environment is crucial for fish survival because fish require appropriate aquatic environment. Artisanal gold mining generates heavy metal waste in Lebong Regency, polluting the river flows. Heavy metals released into the aquatic environment generate water pollution problems due to their toxicity, persistence, and bio-accumulation in organism. The aim of this study was to investigate the histology of fish gill organs in the river contamined by heavy metals. Fish samples were taken by purposive sampling. Histological sections using the paraffin method and hematoxylin-eosin staining. The result of mercury detected in water is 0.01mg/L, exceeded maximum limit in river based on class II water quality standard (0.002mg/L). Histopathology of gills H. nemurus and T. Tricopterus fish (HAI scores <20) showed slight alterations such as epithelial lifting, secondary lamella fusion, and hyperplasia. Rasbora sp., M.circumcinctus, and O.niloticus gills fish (HAI scores>100) had severe irreversible damage, marked by telangiectasis at the tips of the secondary lamella. This is due to the presence of heavy metal contaminants in the water, that causes histopathological damage to fish gills. Parasitic infections were also discovered in some fish gills, impairing their function for respiratory and excretory organs which can be caused by low water quality.
The Comparison between Tree Sorrel and Snake Plant on the Hatchability Inhibition of Apple Snail Eggs Fatimatuzzahra, Fatimatuzzahra; Putriana, Adetha; Jumadi, Jemmy; Lestari, Dian Fita; Anggoro, Bambang Sri
Biosfer: Jurnal Tadris Biologi Vol 11 No 1 (2020): Biosfer: Jurnal Tadris Biologi
Publisher : UNIVERSITAS ISLAM NEGERI RADEN INTAN LAMPUNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/biosfer.v1i1.6145

Abstract

This study aimed to compare and determine the hatchability inhibition of the tree sorrel extract (Averrhoa bilimbi L.) and snake plant as natural ovicide of apple snail (Pomacea canaliculata L.). This study employed the completely randomized design (CRD). The negative controls were the extracts with the concentrations of 1%, 1.5%, 2%, 2.5%, 3%, and a positive control. Data analysis used was one-way ANOVA and then continued by Least Significant Difference (LSD) test. The results showed that tree sorrel extract with 3% concentration had the highest inhibitory on the hatchability of apple snail eggs compared to the snake plant extract (Sansevieria trifasciata P.) with a comparison value of 19.47%. Perbandingandaya Hambat Tetas Telur Keong Mas dari Buah Belimbing Wuluh dan Daun Lidah MertuaAbstrak: Tujuan penelitian ini untuk membandingkan dan mengetahui daya hambat tetas telur keong mas dari ekstrak buah belimbing wuluh (Averrhoa bilimbi L.) dan daun lidah mertua sebagai ovisida alami keong mas (Pomacea canaliculata L.). Desain penelitian menggunakan Rancangan Acak Lengkap (RAL) dengan konsentrasi yaitu kontrol negatif, 1%, 1,5%, 2%, 2,5%, 3% dan kontrol positif. Analisis data menggunakan uji One Way Anova dilanjutkan dengan ujiBeda NyataTerkecil (BNT). Hasil penelitian menunjukkan bahwa ekstrak buah belimbing wuluh dengan konsentrasi 3% mempunyai daya hambat tertinggi terhadap penetasan telur keong mas dibandingkan ekstrak daun lidah mertua (Sansevieria trifasciata P.), yaitu sebesar 19,47%.
Pengaruh Pemberian Perasan Lobak Putih (Raphanus sativus L.) dan Bengkuang (Pachyrhizus erosus L.) terhadap Kadar Glukosa Darah pada Mencit Model Diabetes Pertiwi, Reza; Khodijah, Petri Siti; Aniza, Mifta Violina; Kurniawati, Noval; Kurniati, Eni; Handayani, Dian; Lestari, Dian Fita; Notriawan, Doni
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 1 (2022): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i1.3027

Abstract

Kadar glukosa darah adalah jumlah kandungan glukosa yang ada pada plasma darah. Pengukuran kadar glukosa darah puasa merupakan salah satu metode untuk mengidentifikasi penyakit diabetes melitus pada seseorang. Bengkuang memiliki serat larut air yang dapat memperlambat absorpsi glukosa sehingga dapat menurunkan kadar glukosa darah. Lobak putih memiliki kesamaan jenis dengan bengkuang yaitu merupakan jenis tanaman umbi yang diharapkan memiliki efek yang sama dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian perasan lobak putih dan bengkuang terhadap kadar glukosa darah mencit yang diinduksi aloksan sebagai model diabetes. Mencit dibagi menjadi 8 kelompok dengan pembagian secara random dan dipuasakan selama 8 jam, pada hari ke–0 diukur kadar glukosa darahnya sebagai kadar glukosa darah awal. Kelompok I sebagai kontrol normal yang tidak diberi induksi aloksan dan diberi aquades. Pada kelompok II-VI, mencit diinduksi aloksan dengan dosis 200 mg/kg BB secara intraperitoneal. Setelah aloksan diinduksikan, diukur kadar glukosa darah mencit pada hari ke-3. Setelah didapati kadar glukosa darah mencit yang tinggi, kelompok mencit II diberi aquades, kelompok III diberi glibenklamid 0,013 mg/20 gBB mencit, kelompok IV diberi perasan lobak putih 0,1 ml/20 gBB, kelompok V diberi perasan lobak putih dan bengkuang 2:1, kelompok VI diberi perasan lobak putih dan bengkuang 1:1, kelompok VII diberi perasan lobak putih dan bengkuang 1:2, kelompok VIII diberi perasan bengkuang 0,1 ml/20 gBB. Pemberian perasan lobak putih dan bengkuang dapat menurunkan kadar glukosa darah.
Co-Authors Aniza, Mifta Violina Aprira, Aprira Ashar Muda Lubis Atmaja, Vestidhia Yunisya Bambang Sri Anggoro Bastian, Muhammad Chandra CHOIRUL MUSLIM Dian Handayani Edward, Edward Eliza Febrianti Eni Kurniati, Eni Farisa Retno Fatimatuzzahra Fatimatuzzahra Fatimatuzzahra, . Febrianti, Eliza Helmiyetti, . Hengki Turnando Ibranio Risditama Jarulis Jarulis Jumadi, Jemmy Kamilah, Santi Nurul Khodijah, Petri Siti Kurniawati, Noval Notriawan, Doni Putra, Apriza Hongko Putriana, Adetha Resiliani, Tiara Reza Pertiwi Santi Nurul Kamilah Sianipar, Agnes Petra Sipriyadi Utama, Ahmat Fakhri Vestidhia Yunisya Atmaja Wulandari, Gustina Dwi Wulansari, Shahnaz Sabrina Wulansari, Shahnaz Shabrina