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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research
Kenzi, Ignatio Armando
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Comparison of Inflammation, Pain, and Recovery in Colorectal Cancer Patients Undergoing Surgery with General Anesthesia and Combined Epidural Kenzi, Ignatio Armando; Hartawan, IGAG Utara; Sidemen, IGP Sukrana; Agung Senapathi, Tjokorda Gde; Gede Widnyana, I Made
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.2002

Abstract

Colorectal cancer has a high incidence and mortality rate. Surgery can increase the cytokine IL-6 which triggers inflammation and metastasis. The combination of general and epidural anesthesia has the potential to suppress IL-6, improve the tumor microenvironment, provide analgesia and improve postoperative recovery. To compare the effectiveness of postoperative analgesia quality in colorectal cancer patients receiving general anesthesia with combined epidural anesthesia. The single blind RCT study involved 44 patients who underwent surgery on colorectal cancer at Prof. Ngoerah Hospital. The study subjects were divided into two groups, group K who received general anesthesia and group P who received general anesthesia combined with epidural anesthesia. Patients' IL-6 will be evaluated preoperatively and 6 hours postoperatively. VAS and QOR-15 will be assessed 24 hours postoperatively. Of the 44 patients analyzed, the combined general anesthesia with epidural anesthesia group showed a significantly lower difference in IL-6 levels compared to the general anesthesia alone group of -14.69 [95% CI, p = <0.001]. The 24-hour postoperative VAS score was significantly lower than conventional general anesthesia, both in stationary and mobile conditions. In postoperative recovery, it was found that conventional general anesthesia combined with epdiural anesthesia gave greater QOR-15 results compared to conventional general anesthesia. General anesthesia combined with epidural anesthesia in colorectal cancer patients undergoing surgery can provide a lower difference in IL-6, lower VAS and higher QOR-15 postoperative satisfaction than the general anesthesia group.
Management of Anesthesia in Patient with Osteogenesis Imperfecta Type IV and Fractures on Tibia and Fibula: A Case Report Kenzi, Ignatio Armando; Otniel Adrians Labobar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 1 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i1.908

Abstract

Background: Osteogenesis imperfecta (OI), known as brittle bone disease, is a rare inherited and genetic skeletal disorder characterized by a significantly heightened risk of fragility fractures. About 1 in 15 to 20.000 births are affected with OI. these defects may moreover be combined with an airway that's troublesome to oversee, platelet dysfunctions, and other issues. The perioperative administration of anesthesia speaks to a significant challenge. Subsequently, it is critical to be able to anticipate the dangers during the perioperative period and to define and actualize particular high-quality anesthesia administration plans for such patients when they involve injury. Case presentation: We present a case of a female patient 26 years old with known OI type IV who underwent Osteotomy and Open Reduction Internal Fixation with plate and screw (ORIF PS) on her left Tibia and Fibula. In this case, we present the anesthesia technique with general anesthesia using a metal wire-enforced endotracheal tube to prevent partial obstruction due to kyphoscoliosis. Conclusion: It is crucial to assess the severity of the disease, identify risk factors in advance, and optimize the preoperative health status of individuals with OI.
Management of Anesthesia in Patient with Osteogenesis Imperfecta Type IV and Fractures on Tibia and Fibula: A Case Report Kenzi, Ignatio Armando; Otniel Adrians Labobar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 1 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i1.908

Abstract

Background: Osteogenesis imperfecta (OI), known as brittle bone disease, is a rare inherited and genetic skeletal disorder characterized by a significantly heightened risk of fragility fractures. About 1 in 15 to 20.000 births are affected with OI. these defects may moreover be combined with an airway that's troublesome to oversee, platelet dysfunctions, and other issues. The perioperative administration of anesthesia speaks to a significant challenge. Subsequently, it is critical to be able to anticipate the dangers during the perioperative period and to define and actualize particular high-quality anesthesia administration plans for such patients when they involve injury. Case presentation: We present a case of a female patient 26 years old with known OI type IV who underwent Osteotomy and Open Reduction Internal Fixation with plate and screw (ORIF PS) on her left Tibia and Fibula. In this case, we present the anesthesia technique with general anesthesia using a metal wire-enforced endotracheal tube to prevent partial obstruction due to kyphoscoliosis. Conclusion: It is crucial to assess the severity of the disease, identify risk factors in advance, and optimize the preoperative health status of individuals with OI.
Co-Authors Hartawan, IGAG Utara I Made Gede Widnyana Otniel Adrians Labobar Sidemen, IGP Sukrana Tjokorda Gde Agung Senapathi